Search Results - "Ausman, Jonathan"
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Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis
Published in Cell death & disease (26-02-2022)“…Dynamic changes in physiologic oxygen are required for proper placenta development; yet, when low-oxygen levels persist, placental development is halted,…”
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Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction
Published in Frontiers in cell and developmental biology (04-05-2021)“…Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of…”
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Ceramide-induced BOK promotes mitochondrial fission in preeclampsia
Published in Cell death & disease (20-02-2018)“…Mitochondria are in a constant balance of fusing and dividing in response to cellular cues. Fusion creates healthy mitochondria, whereas fission results in…”
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A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia
Published in Scientific reports (22-09-2017)“…Preeclampsia (PE), an hypertensive disorder of pregnancy, exhibits increased circulating levels of a short form of the auxillary TGF-beta (TGFB) receptor…”
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Fibronectin and JMJD6 Signature in Circulating Placental Extracellular Vesicles for the Detection of Preeclampsia
Published in Endocrinology (Philadelphia) (01-04-2023)“…Preeclampsia (PE) is a major obstetric complication that is challenging to predict. Currently, there are limited tools to assess placental health/function in…”
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Fibronectin and JMJD6 Signature in Circulating Placental Extracellular Vesicles for the Detection of Preeclampsia
Published in Endocrinology (Philadelphia) (11-02-2023)“…Abstract Preeclampsia (PE) is a major obstetric complication that is challenging to predict. Currently, there are limited tools to assess placental…”
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Alterations in Mitochondrial Dynamics in Placentae From Women Who Smoke During Pregnancy
Published in Placenta (Eastbourne) (01-08-2019)Get full text
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Secretion of sFLT1 and sENG into the maternal circulation
Published in Placenta (Eastbourne) (01-09-2016)Get full text
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Secretion of s FLT1 and s ENG into the maternal circulation
Published in Placenta (Eastbourne) (2016)Get full text
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Regulation of mitochondrial fission by ceramide-induced Bcl-2-related ovarian killer in preeclampsia
Published 2017“…Mitochondrial fission (MF) is regulated by the dynamin-related protein 1 (DRP1), and its excess is implicated in a number of human diseases. Preeclampsia (PE)…”
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Dissertation