Search Results - "Ausín, Cristina"

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    Protection of the 2′-Hydroxy Function of Ribonucleosides as an Iminooxymethyl Propanoate and Its 2′-O-Deprotection through an Intramolecular Decarboxylative Elimination Process by Cieślak, Jacek, Grajkowski, Andrzej, Ausín, Cristina, Beaucage, Serge L.

    Published in European journal of organic chemistry (01-12-2016)
    “…The design and implementation of 2′‐hydroxy protecting groups for ribonucleosides is still a daunting challenge to overcome when assembling RNA (ribonucleic…”
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    The 2-Cyano-2,2-dimethylethanimine-N-oxymethyl Group for the 2′-Hydroxyl Protection of Ribonucleosides in the Solid-Phase Synthesis of RNA Sequences by Cieślak, Jacek, Ausín, Cristina, Grajkowski, Andrzej, Beaucage, Serge L.

    Published in Chemistry : a European journal (02-04-2013)
    “…The reaction of 2‐cyano‐2‐methyl propanal with 2′‐O‐aminooxymethylribonucleosides leads to stable and yet reversible…”
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    Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs by Ausín, Cristina, Kauffman, Jon S., Duff, Robert J., Shivaprasad, Shankaramma, Beaucage, Serge L.

    Published in Tetrahedron (01-01-2010)
    “…Heat-sensitive thiophosphate protecting groups derived from the alcohol 4 or 10 have provided insights in the design of DNA oligonucleotide prodrugs. Indeed,…”
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    Permanent or reversible conjugation of 2′-O- or 5′-O-aminooxymethylated nucleosides with functional groups as a convenient and efficient approach to the modification of RNA and DNA sequences by Cie lak, Jacek, Grajkowski, Andrzej, Ausín, Cristina, Gapeev, Alexei, Beaucage, Serge L.

    Published in Nucleic acids research (01-03-2012)
    “…2′-O-Aminooxymethyl ribonucleosides are prepared from their 3′,5′-disilylated 2′-O-phthalimidooxymethyl derivatives by treatment with NH4F in MeOH. The…”
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    Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates by Puig, Montserrat, Grajkowski, Andrzej, Boczkowska, Malgorzata, Ausín, Cristina, Beaucage, Serge L, Verthelyi, Daniela

    Published in Nucleic acids research (01-12-2006)
    “…CpG oligodeoxynucleotides (ODN) show promise as immunoprotective agents and vaccine adjuvants. CpG ODN type D were shown to improve clinical outcome in rhesus…”
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    Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs by Grajkowski, Andrzej, Pedras-Vasconcelos, Joao, Wang, Vivian, Ausín, Cristina, Hess, Sonja, Verthelyi, Daniela, Beaucage, Serge L.

    Published in Nucleic acids research (01-01-2005)
    “…A CpG-containing DNA oligonucleotide functionalized with the 2-(N-formyl-N-methyl)aminoethyl thiophosphate protecting group (CpG ODN fma1555) was prepared from…”
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    Cyclic Phosphate-Linked Oligosaccharides:  Synthesis and Conformational Behavior of Novel Cyclic Oligosaccharide Analogues by Di Fabio, Giovanni, Randazzo, Antonio, D'Onofrio, Jennifer, Ausín, Cristina, Pedroso, Enrique, Grandas, Anna, De Napoli, Lorenzo, Montesarchio, Daniela

    Published in Journal of organic chemistry (28-04-2006)
    “…CyPLOS (cyclic phosphate-linked oligosaccharides), that is, novel cyclic oligosaccharide surrogates, consisting of two, three, and four…”
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    Safety outcomes when switching between biosimilars and reference biologics: A systematic review and meta-analysis by Herndon, Thomas M, Ausin, Cristina, Brahme, Nina N, Schrieber, Sarah J, Luo, Michelle, Andrada, Frances C, Kim, Carol, Sun, Wanjie, Zhou, Lingjie, Grosser, Stella, Yim, Sarah, Ricci, M. Stacey

    Published in PloS one (03-10-2023)
    “…Biosimilars are increasingly available for the treatment of many serious disorders, however some concerns persist about switching a patient to a biosimilar…”
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    Synthesis of Amino- and Guanidino-G-Clamp PNA Monomers by Ausín, Cristina, Ortega, José-Antonio, Robles, Jordi, Grandas, Anna, Pedroso, Enrique

    Published in Organic letters (14-11-2002)
    “…Syntheses of the protected amino- and guanidino-G-clamp PNA monomers, 9a and 9b, respectively, have been accomplished in eight steps from 5-bromouracil…”
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    Visceral extra‐abdominal panniculitis after COVID19 by Ausín‐García, Cristina, Cervilla‐Muñoz, Eva, Demelo‐Rodríguez, Pablo, Villalba‐García, María Victoria, Alvarez‐Sala Walther, Luis A.

    “…“Retractile mesenteritis” was the first name given to a rare, benign, inflammatory disease that affects the adipose tissue of the intestinal mesentery and less…”
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    31P NMR Study of the Desulfurization of Oligonucleoside Phosphorothioates Effected by “Aged” Trichloroacetic Acid Solutions by Cieślak, Jacek, Ausín, Cristina, Chmielewski, Marcin K, Kauffman, Jon S, Snyder, John, Del-Grosso, Alfred, Beaucage, Serge L

    Published in Journal of organic chemistry (15-04-2005)
    “…When employing phosphoramidites 1a−d in the solid-phase synthesis of oligonucleoside phosphorothioates, the thermolytic 2-[N-methyl-N-(2-pyridyl)]aminoethyl…”
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    Solid-Phase Synthesis of Thermolytic DNA Oligonucleotides Functionalized with a Single 4-Hydroxy-1-butyl or 4-Phosphato-/Thiophosphato-1-butyl Thiophosphate Protecting Group by Grajkowski, Andrzej, Ausín, Cristina, Kauffman, Jon S, Snyder, John, Hess, Sonja, Lloyd, John R, Beaucage, Serge L

    Published in Journal of organic chemistry (02-02-2007)
    “…Several thermolytic CpG-containing DNA oligonucleotides analogous to 1 have been synthesized to serve as potential immunotherapeutic oligonucleotide prodrug…”
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