Search Results - "Auriola, S"

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes by Laine, J. E., Auriola, S., Pasanen, M., Juvonen, R. O.

“…Acetaminophen is a widely used analgesic antipyretic agent. When used at low doses, it is a safe drug, but at higher doses it can cause acute hepatic necrosis…”
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HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage by Loppi, S., Kolosowska, N., Kärkkäinen, O., Korhonen, P., Huuskonen, M., Grubman, A., Dhungana, H., Wojciechowski, S., Pomeshchik, Y., Giordano, M., Kagechika, H., White, A., Auriola, S., Koistinaho, J., Landreth, G., Hanhineva, K., Kanninen, K., Malm, T.

“…•HX600 alleviates ischemia induced deficits in a mouse model of ischemic stroke.•HX600 treatment protects neurons from inflammation induced death in…”
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Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies by Kostiainen, R., Kotiaho, T., Kuuranne, T., Auriola, S.

“…The study of the metabolic fate of drugs is an essential and important part of the drug development process. The analysis of metabolites is a challenging task…”
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A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen‐containing bisphosphonates by Mönkkönen, Hannu, Auriola, Seppo, Lehenkari, Petri, Kellinsalmi, Maarit, Hassinen, Ilmo E, Vepsäläinen, Jouko, Mönkkönen, Jukka

“…Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess bone resorption. On the basis of…”
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Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity by Saarelainen, S., Rytkönen-Nissinen, M., Rouvinen, J., Taivainen, A., Auriola, S., Kauppinen, A., Kinnunen, T., Virtanen, T.

“…Summary Background Although knowledge of the IgE cross‐reactivity between allergens is important for understanding the mechanisms of allergy, the regulation of…”
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Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions by Palmgrén, Joni J., Mönkkönen, Jukka, Korjamo, Timo, Hassinen, Anssi, Auriola, Seppo

“…Loss of drug content during cell culture transport experiment can lead to misinterpretations in permeability analysis. This study analyses drug adsorption to…”
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Molecular mechanisms of action of bisphosphonates by Rogers, M.J, Frith, J.C, Luckman, S.P, Coxon, F.P, Benford, H.L, M̈onkk̈onen, J, Auriola, S, Chilton, K.M, Russell, R.G.G

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Transplacental transfer of melamine by Partanen, H, Vähäkangas, K, Woo, C.S.J, Auriola, S, Veid, J, Chen, Y, Myllynen, P, El Nezami, H

“…Abstract Objective To characterize transplacental transfer of melamine and related mechanisms as well as toxicity using human placental perfusion and cultured…”
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Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells by Stenman, S.M, Lindfors, K, Venäläinen, J.I, Hautala, A, Männistö, P.T, Garcia-Horsman, J.A, Kaukovirta-Norja, A, Auriola, S, Mauriala, T, Mäki, M, Kaukinen, K

“…Currently the only treatment for coeliac disease is a lifelong gluten-free diet excluding food products containing wheat, rye and barley. There is, however,…”
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In vitro evaluation of the effect of cyclodextrin complexation on pulmonary deposition of a peptide, cyclosporin A by Matilainen, L., Järvinen, K., Toropainen, T., Näsi, E., Auriola, S., Järvinen, T., Jarho, P.

“…The effect of hydroxypropyl-α-cyclodextrin (HP-α-CD) complexation on in vitro pulmonary deposition of a cyclic peptide cyclosporin A (CsA) was studied. In…”
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Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry by PALMGREN, Joni J, TÖYRÄS, Anu, MAURIALA, Timo, MÖNKKÖNEN, Jukka, AURIOLA, Seppo

“…In this study, we describe a simple liquid extraction (methanol/choloroform, 1:1, v/v) method for endogenous free cholesterol and administered sterols…”
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Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes by Qu, C.-J., M.D, Jauhiainen, M., B.Sc, Auriola, S., Ph.D, Helminen, H.J., Ph.D, Lammi, M.J., Ph.D

“…Summary Objective To analyze the effects of exogenously added glucose (Glc), glucosamine (GlcN) and glucosamine sulfate (GS) on the intracellular UDP-hexoses…”
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Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy by Saarelainen, S., Taivainen, A., Rytkönen-Nissinen, M., Auriola, S., Immonen, A., Mäntyjärvi, R., Rautiainen, J., Kinnunen, T., Virtanen, T.

“…Summary Background The use of recombinant allergens for the diagnosis and immunotherapy of allergy may offer several advantages over allergen extracts…”
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Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo by Raunio, H., Pokela, N., Puhakainen, K., Rahnasto, M., Mauriala, T., Auriola, S., Juvonen, R. O.

“…This study aimed at elucidating the in vivo metabolism of nicotine both with and without inhibitors of nicotine metabolism. Second, the role of mouse CYP2A5 in…”
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Determination of long-chain fatty acid acyl-coenzyme A compounds using liquid chromatography–electrospray ionization tandem mass spectrometry by Mauriala, T, Herzig, K.H, Heinonen, M, Idziak, J, Auriola, S

“…Acyl-CoAs have important role in fat and glucose metabolism of the cells. In this study we have developed an on-line HPLC–ESI-MS/MS method for determination of…”
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Zoledronic Acid-Induced IPP/ApppI Formation In Vivo and In Vitro by Kuokkanen, Johanna, Crockett, J.C, Rogers, M.J, Mönkkönen, H, Auriola, S, Mönkkönen, J

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Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes by PELLINEN, P, KULMALA, L, KONTTILA, J, AURIOLA, S, PASANEN, M, JUVONEN, R

“…The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In…”
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The cellular uptake and metabolism of clodronate in RAW 264 macrophages by MÖNKKÖNEN, Hannu, ROGERS, Michael J, MAKKONEN, Niina, NIVA, Sanna, AURIOLA, Seppo, MÖNKKÖNEN, Jukka

“…Non-nitrogen-containing bisphosphonates, such as clodronate (dichloromethylene bisphosphonate), appear to act as prodrugs, their active form being the…”
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PR‐10 protein is induced by copper stress in roots and leaves of a Cu/Zn tolerant clone of birch, Betula pendula by Utriainen, M., Kokko, H., Auriola, S., Sarrazin, O., Kärenlampi, S.

“…The response of a Cu‐ and Zn‐tolerant birch (Betula pendula) clone to copper stress was investigated. The plants were exposed to control and EC50…”
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Overexpression of VEGF-B alters cardiac lipid metabolism and predisposes to heart failure by Tirronen, A, Huusko, J, Lehtonen, M, Hamalainen, W, Hokkanen, K, Auriola, S, Yla-Herttuala, S

“…Abstract Background The compensatory phase of left ventricular hypertrophy (LVH) is characterised by sufficient mitochondrial density and energy production,…”
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