Search Results - "Aureli, Massimo"

Animal Models to Translate Phage Therapy to Human Medicine by Brix, Alessia, Cafora, Marco, Aureli, Massimo, Pistocchi, Anna

“…Phagotherapy, the use of bacteriophages to fight bacterial infections as an alternative to antibiotic treatments, has become of increasing interest in the last…”
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iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis by Schöndorf, David C., Aureli, Massimo, McAllister, Fiona E., Hindley, Christopher J., Mayer, Florian, Schmid, Benjamin, Sardi, S. Pablo, Valsecchi, Manuela, Hoffmann, Susanna, Schwarz, Lukas Kristoffer, Hedrich, Ulrike, Berg, Daniela, Shihabuddin, Lamya S., Hu, Jing, Pruszak, Jan, Gygi, Steven P., Sonnino, Sandro, Gasser, Thomas, Deleidi, Michela

“…Mutations in the acid β-glucocerebrosidase ( GBA1 ) gene, responsible for the lysosomal storage disorder Gaucher’s disease (GD), are the strongest genetic risk…”
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Gangliosides in Podocyte Biology and Disease by Savas, Berkan, Astarita, Giuseppe, Aureli, Massimo, Sahali, Dil, Ollero, Mario

“…Gangliosides constitute a subgroup of glycosphingolipids characterized by the presence of sialic acid residues in their structure. As constituents of cellular…”
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Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1 by Lérias, Joana, Pinto, Madalena, Benedetto, Roberta, Schreiber, Rainer, Amaral, Margarida, Aureli, Massimo, Kunzelmann, Karl

“…Airway epithelial cells express both Ca2+ activated TMEM16A/ANO1 and cAMP activated CFTR anion channels. Previous work suggested a significant crosstalk of…”
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Glycans in autophagy, endocytosis and lysosomal functions by Reggiori, Fulvio, Gabius, Hans-Joachim, Aureli, Massimo, Römer, Winfried, Sonnino, Sandro, Eskelinen, Eeva-Liisa

“…Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and…”
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Turning the spotlight on the oligosaccharide chain of GM1 ganglioside by Chiricozzi, Elena, Di Biase, Erika, Lunghi, Giulia, Fazzari, Maria, Loberto, Nicoletta, Aureli, Massimo, Mauri, Laura, Sonnino, Sandro

“…It is well over a century that glycosphingolipids are matter of interest in different fields of research. The hydrophilic oligosaccharide and the lipid moiety,…”
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Isolation and Analysis of Detergent-Resistant Membrane Fractions by Aureli, Massimo, Grassi, Sara, Sonnino, Sandro, Prinetti, Alessandro

“…The hypothesis that the Golgi apparatus is capable of sorting proteins and sending them to the plasma membrane through "lipid rafts," membrane lipid domains…”
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Novel bicistronic lentiviral vectors correct β-Hexosaminidase deficiency in neural and hematopoietic stem cells and progeny: implications for in vivo and ex vivo gene therapy of GM2 gangliosidosis by Ornaghi, Francesca, Sala, Davide, Tedeschi, Fabiana, Maffia, Maria Chiara, Bazzucchi, Martina, Morena, Francesco, Valsecchi, Manuela, Aureli, Massimo, Martino, Sabata, Gritti, Angela

“…The favorable outcome of in vivo and ex vivo gene therapy approaches in several Lysosomal Storage Diseases suggests that these treatment strategies might…”
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Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation by Ghiroldi, Andrea, Piccoli, Marco, Creo, Pasquale, Cirillo, Federica, Rota, Paola, D'Imperio, Sara, Ciconte, Giuseppe, Monasky, Michelle M, Micaglio, Emanuele, Garatti, Andrea, Aureli, Massimo, Carsana, Emma Veronica, Menicanti, Lorenzo, Pappone, Carlo, Anastasia, Luigi

“…Cardiac fibrosis is a key physiological response to cardiac tissue injury to protect the heart from wall rupture. However, its progression increases heart…”
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Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection by Chiricozzi, Elena, Loberto, Nicoletta, Schiumarini, Domitilla, Samarani, Maura, Mancini, Giulia, Tamanini, Anna, Lippi, Giuseppe, Dechecchi, Maria Cristina, Bassi, Rosaria, Giussani, Paola, Aureli, Massimo

“…Sphingolipids (SLs) are amphiphilic molecules mainly associated with the external leaflet of eukaryotic plasma membrane, and are structural membrane components…”
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Evaluation of phages and liposomes as combination therapy to counteract Pseudomonas aeruginosa infection in wild-type and CFTR-null models by Cafora, Marco, Poerio, Noemi, Forti, Francesca, Loberto, Nicoletta, Pin, Davide, Bassi, Rosaria, Aureli, Massimo, Briani, Federica, Pistocchi, Anna, Fraziano, Maurizio

“…Multi drug resistant (MDR) bacteria are insensitive to the most common antibiotics currently in use. The spread of antibiotic-resistant bacteria, if not…”
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Cross‐talk between CFTR and sphingolipids in cystic fibrosis by Dobi, Dorina, Loberto, Nicoletta, Bassi, Rosaria, Pistocchi, Anna, Lunghi, Giulia, Tamanini, Anna, Aureli, Massimo

“…Cystic fibrosis (CF) is the most common inherited, life‐limiting disorder in Caucasian populations. It is caused by mutations in the gene encoding the cystic…”
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The Role of 3-O-Sulfogalactosylceramide, Sulfatide, in the Lateral Organization of Myelin Membrane by Grassi, Sara, Prioni, Simona, Cabitta, Livia, Aureli, Massimo, Sonnino, Sandro, Prinetti, Alessandro

“…Sulfatide (3- O -sulfogalactosylceramide, SM4s) was isolated by Thudichum from the human brain in 1884. Together with galactosylceramide, its direct metabolic…”
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GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease by Mancini, Giulia, Loberto, Nicoletta, Olioso, Debora, Dechecchi, Maria Cristina, Cabrini, Giulio, Mauri, Laura, Bassi, Rosaria, Schiumarini, Domitilla, Chiricozzi, Elena, Lippi, Giuseppe, Pesce, Emanuela, Sonnino, Sandro, Pedemonte, Nicoletta, Tamanini, Anna, Aureli, Massimo

“…Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is expressed at the apical plasma membrane (PM) of different epithelial cells. The most…”
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Exploring the link between ceramide and ionizing radiation by Aureli, Massimo, Murdica, Valentina, Loberto, Nicoletta, Samarani, Maura, Prinetti, Alessandro, Bassi, Rosaria, Sonnino, Sandro

“…The aim of radiotherapy is to eradicate cancer cells with ionizing radiation; tumor cell death following irradiation can be induced by several signaling…”
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APOL1 polymorphism modulates sphingolipid profile of human podocytes by Valsecchi, Manuela, Cazzetta, Valentina, Oriolo, Ferdinando, Lan, Xiqian, Piazza, Rocco, Saleem, Moin A., Singhal, Pravin C., Mavilio, Domenico, Mikulak, Joanna, Aureli, Massimo

“…Apolipoprotein L1 (APOL1) wild type (G0) plays a role in the metabolism of sphingolipids, glycosphingolipids, sphingomyelin and ceramide, which constitute…”
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Cell surface sphingolipid glycohydrolases in neuronal differentiation and aging in culture by Aureli, Massimo, Loberto, Nicoletta, Lanteri, Patrizia, Chigorno, Vanna, Prinetti, Alessandro, Sonnino, Sandro

“…J. Neurochem. (2011) 116, 891–899. Qualitative and quantitative changes in glycosphingolipids, together with changes in the expression of the corresponding…”
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Deregulated Sphingolipid Metabolism and Membrane Organization in Neurodegenerative Disorders by Piccinini, Marco, Scandroglio, Federica, Prioni, Simona, Buccinnà, Barbara, Loberto, Nicoletta, Aureli, Massimo, Chigorno, Vanna, Lupino, Elisa, DeMarco, Giovanni, Lomartire, Annarosa, Rinaudo, Maria Teresa, Sonnino, Sandro, Prinetti, Alessandro

“…Sphingolipids are polar membrane lipids present as minor components in eukaryotic cell membranes. Sphingolipids are highly enriched in nervous cells, where…”
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GM1 ganglioside exerts protective effects against glutamate‐excitotoxicity via its oligosaccharide in wild‐type and amyotrophic lateral sclerosis motor neurons by Lunghi, Giulia, Di Biase, Erika, Carsana, Emma Veronica, Henriques, Alexandre, Callizot, Noelle, Mauri, Laura, Ciampa, Maria Grazia, Mari, Luigi, Loberto, Nicoletta, Aureli, Massimo, Sonnino, Sandro, Spedding, Michael, Chiricozzi, Elena, Fazzari, Maria

“…Alterations in glycosphingolipid metabolism have been linked to the pathophysiological mechanisms of amyotrophic lateral sclerosis (ALS), a neurodegenerative…”
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Biochemical Characterization of the GBA2 c.1780G>C Missense Mutation in Lymphoblastoid Cells from Patients with Spastic Ataxia by Malekkou, Anna, Samarani, Maura, Drousiotou, Anthi, Votsi, Christina, Sonnino, Sandro, Pantzaris, Marios, Chiricozzi, Elena, Zamba-Papanicolaou, Eleni, Aureli, Massimo, Loberto, Nicoletta, Christodoulou, Kyproula

“…The gene encodes the non-lysosomal glucosylceramidase (NLGase), an enzyme that catalyzes the conversion of glucosylceramide (GlcCer) to ceramide and glucose…”
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