Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

We have used a schedule for soft x-ray therapy of epithelial malignancies that takes into account the clinically diagnosed tumor involution under treatment. We sought to evaluate the effectiveness of this schedule in terms of cure rate and late ulcerations. Patients with 1267 consecutively irradiate...

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Bibliographic Details
Published in:	Journal of the American Academy of Dermatology Vol. 53; no. 6; pp. 993 - 1001
Main Authors:	Schulte, Klaus-Werner, Lippold, Andrea, Auras, Christine, Bramkamp, Gernot, Breitkopf, Claudia, Elsmann, Heinz-Joachim, Habenicht, Eva Maria, Jasnoch, Volker, Müller-Pannes, Helga, Rupprecht, Rainer, Suter, Ludwig
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01-12-2005 Elsevier
Subjects:	Aged Aged, 80 and over Biological and medical sciences Carcinoma, Basal Cell - radiotherapy Carcinoma, Squamous Cell - radiotherapy Dermatology Follow-Up Studies Humans Medical sciences Middle Aged Neoplasm Recurrence, Local - epidemiology Radiotherapy Dosage Retrospective Studies Skin Neoplasms - radiotherapy Tumors of the skin and soft tissue. Premalignant lesions Skin disease Squamous cell carcinoma Treatment Dermatology Soft X ray Skin Malignant tumor Radiotherapy
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Summary:	We have used a schedule for soft x-ray therapy of epithelial malignancies that takes into account the clinically diagnosed tumor involution under treatment. We sought to evaluate the effectiveness of this schedule in terms of cure rate and late ulcerations. Patients with 1267 consecutively irradiated (1988-1992) basal cell and squamous cell carcinomas were followed up (average 77 months). The recurrence rate (5.1%) was related to tumor size and thickness and to the time-dose-fractionation factor. The frequency of ulcerations (6.3%) depended on field size, hardness of the x-rays, and in smaller fields (diameter up to 4 cm) on total dose, and time-dose-fractionation factor. Of all ulcerations, 82.5 % could be conservatively cured. We have no evidence that our radiation schedule is superior to those published by other authors. These results verify the usefulness of soft x-ray therapy for cutaneous epithelial malignancies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0190-9622 1097-6787
DOI:	10.1016/j.jaad.2005.07.045