Search Results - "Auphan, N"

Targeting mitochondrial metabolism in the therapeutic resistance of pancreatic cancer by Abdel Hadi, N., Reyes-Castellanos, G., Masoud, R., Borge, L., Baudoin, E., Auphan Anezin, N., Iovanna, J., Carrier, A.

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Glucocorticoid‐induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor by Helmberg, A., Auphan, N., Caelles, C., Karin, M.

“…Induction of apoptosis in lymphocytes, which may account for the therapeutic effects of glucocorticoids in various diseases including leukemia, depends on the…”
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Glass eel recruitment, Anguilla anguilla (L.), in a Mediterranean lagoon assessed by a glass eel trap: factors explaining the catches by Crivelli, A. J, Auphan, N, Chauvelon, P, Sandoz, A, Menella, J.-Y, Poizat, G

“…Although the colonisation of coastal rivers on the Atlantic and Mediterranean coast by glass eels, Anguilla anguilla, has been well studied and understood, the…”
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Engineered secreted T-cell receptor alpha beta heterodimers by Grégoire, C, Rebaï, N, Schweisguth, F, Necker, A, Mazza, G, Auphan, N, Millward, A, Schmitt-Verhulst, A M, Malissen, B

“…We have produced a soluble form of a mouse alpha beta T-cell antigen receptor (TCR) by shuffling its variable (V) and constant (C) domains to the C region of…”
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Distinct requirements of positive and negative selection for selecting cell type and CD8 interaction by Schonrich, G, Strauss, G, Muller, KP, Dustin, L, Loh, DY, Auphan, N, Schmitt- Verhulst, AM, Arnold, B, Hammerling, GJ

“…We investigated the requirements of positive and negative selection in the thymus for CD8 interaction and the selecting cell type. Thymic epithelial cells are…”
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The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice by Auphan, N, Curnow, J, Guimezanes, A, Langlet, C, Malissen, B, Mellor, A, Schmitt-Verhulst, A M

“…Although much has been learned about CD8 structure-function properties, it has so far not been tested whether the nature of the TCR is sufficient to transfer…”
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Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis by Auphan, Nathalie, DiDonato, Joseph A., Rosette, Caridad, Helmberg, Arno, Karin, Michael

“…Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known cytokines and of several…”
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Gene Profiling Approach to Establish the Molecular Bases for Partial versus Full Activation of Naïve CD8 T Lymphocytes by VERDEIL, GRÉGORY, PUTHIER, DENIS, NGUYEN, CATHERINE, SCHMITT-VERHULST, ANNE-MARIE, AUPHAN-ANEZIN, NATHALIE

“…: When initial antigen encounter involves optimal antigenic and costimulatory stimuli, naïve CD8 T cells undergo a developmental program that leads to their…”
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Immunoregulatory genes and immunosuppression by glucocorticoids by Auphan, N, Didonato, J A, Helmberg, A, Rosette, C, Karin, M

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Comparison of phosphorylation and internalization of the antigen receptor/CD3 complex, CD8, and class I MHC-encoded proteins on T cells. Role of intracytoplasmic domains analyzed with hybrid CD8/class I molecules [published erratum appears in J Immunol 1990 Jan 1;144(1):408] by Boyer, C, Auphan, N, Gabert, J, Blanc, D, Malissen, B, Schmitt-Verhulst, AM

“…We analyzed the phosphorylation and the dynamics of TCR/CD3, CD8 and MHC class I molecules during the activation of a CD8+ cytotoxic T lymphocyte clone and of…”
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Differential Survival of Transferred CD8 T Cells and Host Reconstitution Depending on TCR Avidity for Host-Expressed Alloantigen by Auphan-Anezin, Nathalie, Schmitt-Verhulst, Anne-Marie

“…We transferred naive alloreactive CD8 T cells from TCR transgenic mice to irradiated recipients expressing a partial (H-2Kbm8) or a full (H-2Kb) agonist…”
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Active STAT5 Regulates T-bet and Eomesodermin Expression in CD8 T Cells and Imprints a T-bet-Dependent Tc1 Program with Repressed IL-6/TGF- 1 Signaling by Grange, M., Verdeil, G., Arnoux, F., Griffon, A., Spicuglia, Salvatore, Maurizio, J., Buferne, M., Schmitt-Verhulst, A.-M., Auphan-Anezin, N.

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Multiplex Messenger Assay: Simultaneous, Quantitative Measurement of Expression of Many Genes in the Context of T Cell Activation by Bernard, Karine, Auphan, Nathalie, Granjeaud, Samuel, Victorero, Geneviève, Schmitt-Verhulst, Anne-Marie, Jordan, Bertrand R., Nguyen, Catherine

“…The hybridization signature approach, using colony filters and labeled complex probes, can provide high throughput measurement of gene activity. We describe…”
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The lack of NF-kappa B transactivation and PKC epsilon expression in CD4(+)CD8(+) thymocytes correlates with negative selection by Simon, A K, Auphan, N, Pophillat, M, Boyer, C, Ghosh, S, Rincón, M, Flavell, R A, Schmitt-Verhulst, A M

“…Deletion of autoreactive thymocytes at the DP stage is the basis for tolerance to thymus-expressed self antigens. In this study we investigated whether…”
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Differential requirements for NF-kappaB and AP-1 trans-activation in response to minimal TCR engagement by a partial agonist in naive CD8 T cells by Auphan, N, Ghosh, S, Flavell, R A, Schmitt-Verhulst, A M

“…We investigated the basis for partial reactivity of naive CD8 T cells expressing an alloreactive transgenic TCR in response to a mutant alloantigen. When…”
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The lack of NF- Kappa B transactivation and PKC epsilon expression in CD4 super(+)CD8 super(+) thymocytes correlates with negative selection by Simon, A K, Auphan, N, Pophillat, M, Boyer, C, Ghosh, S, Rincon, M, Flavell, R A, Schmitt-Verhulst, A-M

“…Deletion of autoreactive thymocytes at the DP stage is the basis for tolerance to thymus-expressed self antigens. In this study we investigated whether…”
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The lack of NF-[kappa]B transactivation and PKC[straight epsilon] expression in CD4+CD8+ thymocytes correlates with negative selection by Simon, A K, Auphan, N, Pophillat, M, Boyer, C, Ghosh, S, Rincón, M, Flavell, R A, A-M Schmitt-Verhulst

“…Deletion of autoreactive thymocytes at the DP stage is the basis for tolerance to thymus-expressed self antigens. In this study we investigated whether…”
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Differential Requirements for NF-κB and AP-1 trans -Activation in Response to Minimal TCR Engagement by a Partial Agonist in Naive CD8 T Cells by Auphan, Nathalie, Ghosh, Sankar, Flavell, Richard A., Schmitt-Verhulst, Anne-Marie

“…We investigated the basis for partial reactivity of naive CD8 T cells expressing an alloreactive transgenic TCR in response to a mutant alloantigen. When…”
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Two signaling pathways can lead to Fas ligand expression in CD8+ cytotoxic T lymphocyte clones by Anel, A, Simon, A K, Auphan, N, Buferne, M, Boyer, C, Golstein, P, Schmitt-Verhulst, A M

“…As shown previously, a given cytotoxic T lymphocyte (CTL) clone (KB5.C20) could be induced to express the Fas ligand (FasL) by either T cell receptor (TCR)…”
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Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen by Hämmerling, G J, Schönrich, G, Momburg, F, Auphan, N, Malissen, M, Malissen, B, Schmitt-Verhulst, A M, Arnold, B

“…The studies described here reveal a surprising variety of non-deletional manifestations of tolerance (anergy and unresponsiveness) in both the thymus and…”
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