Search Results - "Aungst, B."

Intestinal permeation enhancers by Aungst, B J

“…This review addresses the field of improving oral bioavailability through the use of excipients that increase intestinal membrane permeability. The critical…”
Get more information

Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism by Aungst, B J

“…The oral route is most preferred for chronic drug therapy. Poor oral bioavailability has the consequences of more variable and poorly controlled plasma…”
Get more information

Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine by SAITOH, H, AUNGST, B. J

“…We investigated the intestinal transport of verapamil, chlorpromazine, and propantheline, particularly their P-glycoprotein-mediated secretion. Permeation of…”
Get full text

The influence of donor and reservoir additives on Caco-2 permeability and secretory transport of HIV protease inhibitors and other lipophilic compounds by AUNGST, Bruce J, NGUYEN, Nhung H, BULGARELLI, James P, OATES-LENZ, Kristi

“…To optimize the conditions for determining Caco-2 permeation of HIV protease inhibitors and other lipophilic compounds, and to compare cyclic urea HIV protease…”
Get full text

P-glycoprotein, secretory transport, and other barriers to the oral delivery of anti-HIV drugs by Aungst, Bruce J.

“…Orally administered anti-HIV drugs must be adequately and consistently absorbed for therapy to be successful. This review discusses the barriers to achieving…”
Get full text

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa by Pinto, Donald J. P, Orwat, Michael J, Wang, Shuaige, Fevig, John M, Quan, Mimi L, Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Luettgen, Joseph M, Liang, Li, Aungst, Bruce J, Wright, Matthew R, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R, Lam, Patrick Y. S

“…Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with…”
Get full text

Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter by Aungst, B J, Rogers, N J, Shefter, E

“…The purpose of this investigation was to develop a method to quantitate insulin absorption, and to compare insulin absorption from various noninjection sites…”
Get more information

Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants by AUNGST, B. J

“…Comparisons were made of branched vs unbranched saturated fatty acids and cis vs trans unsaturated fatty acids as skin penetration enhancers and primary skin…”
Get full text

The secretory intestinal transport of some beta-lactam antibiotics and anionic compounds: a mechanism contributing to poor oral absorption by Saitoh, H, Gerard, C, Aungst, B J

“…The mechanisms of intestinal permeation of several beta-lactam antibiotics and anionic compounds were studied in vitro using excised rat intestinal segments…”
Get more information

Intestinal absorption barriers and transport mechanisms, including secretory transport, for a cyclic peptide, fibrinogen antagonist by AUNGST, B. J, SAITOH, H

“…The intestinal absorption of DMP 728, a cyclic peptide fibrinogen antagonist, was examined with the goals of identifying the cause(s) of its low oral…”
Get full text

Improvement of the intestinal absorption of a peptidomimetic, boronic acid thrombin inhibitor possibly utilizing the oligopeptide transporter by SAITOH, H, AUNGST, B. J

Get full text

Intranasal absorption of oxymorphone by Hussain, M A, Aungst, B J

“…The nasal bioavailability of oxymorphone HCI was determined. Rats were surgically prepared to isolate the nasal cavity, into which a solution of oxymorphone…”
Get more information

Amphiphilic vehicles improve the oral bioavailability of a poorly soluble HIV protease inhibitor at high doses by Aungst, Bruce J, Nguyen, Nhung H, Rogers, Nancy J, Rowe, Susan M, Hussain, Munir A, White, Susan J, Shum, Linyee

“…DMP 323 is the first clinical candidate from a novel series of HIV protease inhibitors having a cyclic urea structural backbone. In dogs dosed with…”
Get full text

Restricted intestinal absorption of some β-lactam antibiotics by an energy-dependent efflux system in rat intestine by SAITOH, H, FUJISAKI, H, AUNGST, B. J, MIYAZAKI, K

“…The purpose of this study was to examine factors limiting the intestinal absorption of orally inactive beta-lactam antibiotics. Permeation behaviors of various…”
Get full text

Effects of structural modifications on the intestinal permeability of angiotensin II receptor antagonists and the correlation of in vitro, in situ, and in vivo absorption by RIBADENEIRA, M. D, AUNGST, B. J, EYERMANN, C. J, SHIEW-MEI HUANG

“…The effects of structural modifications on the membrane permeability of angiotensin II (Ang II) receptor antagonists and the usefulness of in vitro and in situ…”
Get full text

Sustained propranolol delivery and increased oral bioavailability in dogs given a propranolol laurate salt by AUNGST, B. J, HUSSAIN, M. A

Get full text

The effect of absorption enhancers on the oral absorption of the GP IIB/IIIA receptor antagonist, DMP 728, in rats and dogs by BURCHAM, D. L, AUNGST, B. A, MUNIR HUSSAIN, GORKO, M. A, QUON, C. Y, HUANG, S.-M

Get full text

The de novo design and synthesis of cyclic urea inhibitors of factor Xa : Optimization of the S4 ligand by GALEMMO, R. A, WELLS, B. L, KNABB, R. M, WEXLER, R. R, ROSSI, K. A, ALEXANDER, R. S, DOMINGUEZ, C, MADUSKUIE, T. P, STOUTEN, P. F. W, WRIGHT, M. R, AUNGST, B. J, WONG, P. C

“…In this report refinements to the S4 ligand group leads to compound 19, an inhibitor of fXa with good potency in vitro and an improved pharmacokinetic profile…”
Get full text

Intranasal absorption of the platelet glycoprotein IIb/IIIa receptor antagonist, DMP 755, and the effect of anesthesia on nasal bioavailability by Hussain, M A, Aungst, B J, Kapil, R, Mousa, S A

“…Intranasal absorption and bioavailability of DMP 755, a peptidomimetic, platelet glycoprotein IIb/IIIa receptor antagonist, were examined in anesthetized and…”
Get more information

Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system by Nakayama, Akira, Saitoh, Hiroshi, Oda, Masako, Takada, Masahiko, Aungst, Bruce J

“…This study was aimed to characterize the absorption behavior of vinblastine (VLB), a well-known substrate of P-glycoprotein (P-gp), from rat small intestine,…”
Get full text