Search Results - "Aung, Aereas"

Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury by Agrawal, Gaurav, Aung, Aereas, Varghese, Shyni

“…Engineered skeletal muscle tissues can be used for in vitro studies that require physiologically relevant models of native tissues. Herein, we describe the…”
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Osteoarthritic chondrocyte–secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cells by Aung, Aereas, Gupta, Gunjan, Majid, Ghassemian, Varghese, Shyni

“…Objective The potential of stem cells to repair compromised cartilage tissue, such as in osteoarthritis (OA), depends strongly on how transplanted cells…”
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Engineering the cell–material interface for controlling stem cell adhesion, migration, and differentiation by Ayala, Ramses, Zhang, Chao, Yang, Darren, Hwang, Yongsung, Aung, Aereas, Shroff, Sumeet S, Arce, Fernando T, Lal, Ratnesh, Arya, Gaurav, Varghese, Shyni

“…Abstract The effective utilization of stem cells in regenerative medicine critically relies upon our understanding of the intricate interactions between cells…”
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Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform by Aung, Aereas, Theprungsirikul, Jomkuan, Lim, Han Liang, Varghese, Shyni

“…The integration of three-dimensional micropatterning with microfluidics provides a unique opportunity to create perfusable tissue constructs in vitro. Herein,…”
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Controlling timing and location in vaccines by Irvine, Darrell J., Aung, Aereas, Silva, Murillo

“…Vaccines are one of the most powerful technologies supporting public health. The adaptive immune response induced by immunization arises following appropriate…”
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An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment by Aung, Aereas, Kumar, Vardhman, Theprungsirikul, Jomkuan, Davey, Shruti K, Varghese, Shyni

“…Recruitment of immune cells to a tumor is determined by the complex interplay between cellular and noncellular components of the tumor microenvironment…”
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Modulating Antigen Availability in Lymphoid Organs to Shape the Humoral Immune Response to Vaccines by Aung, Aereas, Irvine, Darrell J

“…Primary immune responses following vaccination are initiated in draining lymph nodes, where naive T and B cells encounter Ag and undergo coordinated steps of…”
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Deciphering the Mechanics of Cancer Spheroid Growth in 3D Environments through Microfluidics Driven Mechanical Actuation by Aung, Aereas, Davey, Shruti K., Theprungsirikul, Jomkuan, Kumar, Vardhman, Varghese, Shyni

“…Uncontrolled growth of tumor cells is a key contributor to cancer‐associated mortalities. Tumor growth is a biomechanical process whereby the cancer cells…”
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Low protease activity in B cell follicles promotes retention of intact antigens after immunization by Aung, Aereas, Cui, Ang, Maiorino, Laura, Amini, Ava P, Gregory, Justin R, Bukenya, Maurice, Zhang, Yiming, Lee, Heya, Cottrell, Christopher A, Morgan, Duncan M, Silva, Murillo, Suh, Heikyung, Kirkpatrick, Jesse D, Amlashi, Parastoo, Remba, Tanaka, Froehle, Leah M, Xiao, Shuhao, Abraham, Wuhbet, Adams, Josetta, Love, J Christopher, Huyett, Phillip, Kwon, Douglas S, Hacohen, Nir, Schief, William R, Bhatia, Sangeeta N, Irvine, Darrell J

“…The structural integrity of vaccine antigens is critical to the generation of protective antibody responses, but the impact of protease activity on vaccination…”
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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade by Wang, Chensu, Cui, Ang, Bukenya, Maurice, Aung, Aereas, Pradhan, Dikshant, Whittaker, Charles A., Agarwal, Yash, Thomas, Ayush, Liang, Simon, Amlashi, Parastoo, Suh, Heikyung, Spranger, Stefani, Hacohen, Nir, Irvine, Darrell J.

“…Treatments aiming to augment immune checkpoint blockade (ICB) in cancer often focus on T cell immunity, but innate immune cells may have important roles to…”
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Three-Dimensional Monolayer Stress Cytometry by Serrano, Ricardo, Aung, Aereas, Varghese, Shyni, Carlos del Alamo, Juan

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Three-Dimensional Monolayer Stress Microscopy by Serrano, Ricardo, Aung, Aereas, Yeh, Yi-Ting, Varghese, Shyni, Lasheras, Juan C., del Álamo, Juan C.

“…Many biological processes involve the collective generation and transmission of mechanical stresses across cell monolayers. In these processes, the monolayer…”
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3D Traction Stresses Activate Protease-Dependent Invasion of Cancer Cells by Aung, Aereas, Seo, Young N., Lu, Shaoying, Wang, Yingxiao, Jamora, Colin, del Álamo, Juan C., Varghese, Shyni

“…Cell invasion and migration that occurs, for example, in cancer metastasis is rooted in the ability of cells to navigate through varying levels of physical…”
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Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens by Read, Benjamin J., Won, Lori, Kraft, John C., Sappington, Isaac, Aung, Aereas, Wu, Shengwei, Bals, Julia, Chen, Chengbo, Lee, Kelly K., Lingwood, Daniel, King, Neil P., Irvine, Darrell J.

“…Nanoparticle (NP) vaccine formulations promote immune responses through multiple mechanisms. We recently reported that mannose-binding lectin (MBL) triggers…”
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3D cardiac μtissues within a microfluidic device with real-time contractile stress readout by Aung, Aereas, Bhullar, Ivneet Singh, Theprungsirikul, Jomkuan, Davey, Shruti Krishna, Lim, Han Liang, Chiu, Yu-Jui, Ma, Xuanyi, Dewan, Sukriti, Lo, Yu-Hwa, McCulloch, Andrew, Varghese, Shyni

“…We present the development of three-dimensional (3D) cardiac microtissues within a microfluidic device with the ability to quantify real-time contractile…”
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Three-Dimensional Monolayer Stress Microscopy by Serrano, Ricardo, Aung, Aereas, Varghese, Shyni, del Álamo, Juan C.

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Dynamic Electromechanical Hydrogel Matrices for Stem Cell Culture by Lim, Han L., Chuang, Jessica C., Tran, Tuan, Aung, Aereas, Arya, Gaurav, Varghese, Shyni

“…Hydrogels have numerous biomedical applications including synthetic matrices for cell culture and tissue engineering. Here we report the development of…”
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Three-Dimensional Fourier Monolayer Stress Microscopy by Serrano, Ricardo, Aung, Aereas, Varghese, Shyni, Del Alamo, Juan Carlos

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A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity by Silva, Murillo, Kato, Yu, Melo, Mariane B, Phung, Ivy, Freeman, Brian L, Li, Zhongming, Roh, Kangsan, Van Wijnbergen, Jan W, Watkins, Hannah, Enemuo, Chiamaka A, Hartwell, Brittany L, Chang, Jason Y H, Xiao, Shuhao, Rodrigues, Kristen A, Cirelli, Kimberly M, Li, Na, Haupt, Sonya, Aung, Aereas, Cossette, Benjamin, Abraham, Wuhbet, Kataria, Swati, Bastidas, Raiza, Bhiman, Jinal, Linde, Caitlyn, Bloom, Nathaniel I, Groschel, Bettina, Georgeson, Erik, Phelps, Nicole, Thomas, Ayush, Bals, Julia, Carnathan, Diane G, Lingwood, Daniel, Burton, Dennis R, Alter, Galit, Padera, Timothy P, Belcher, Angela M, Schief, William R, Silvestri, Guido, Ruprecht, Ruth M, Crotty, Shane, Irvine, Darrell J

“…Saponins are potent and safe vaccine adjuvants, but their mechanisms of action remain incompletely understood. Here, we explored the properties of several…”
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Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR by Zhang, Angela Q., Hostetler, Alexander, Chen, Laura E., Mukkamala, Vainavi, Abraham, Wuhbet, Padilla, Lucia T., Wolff, Alexandra N., Maiorino, Laura, Backlund, Coralie M., Aung, Aereas, Melo, Mariane, Li, Na, Wu, Shengwei, Irvine, Darrell J.

“…The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an effective target…”
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