Search Results - "Aulin, Linda B. S"

Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review by Démaris, Alix, Widigson, Ella S. K, Ilvemark, Johan F. K. F, Steenholdt, Casper, Seidelin, Jakob B, Huisinga, Wilhelm, Michelet, Robin, Aulin, Linda B. S, Kloft, Charlotte

“…Ulcerative colitis (UC) is part of the inflammatory bowels diseases, and moderate to severe UC patients can be treated with anti-tumour necrosis α monoclonal…”
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Design principles of collateral sensitivity-based dosing strategies by Aulin, Linda B. S., Liakopoulos, Apostolos, van der Graaf, Piet H., Rozen, Daniel E., van Hasselt, J. G. Coen

“…Collateral sensitivity (CS)-based antibiotic treatments, where increased resistance to one antibiotic leads to increased sensitivity to a second antibiotic,…”
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A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis by Liu, Feiyan, Aulin, Linda B. S., Kossen, Sebastiaan S. A., Cathalina, Julius, Bremmer, Marlotte, Foks, Amanda C., van der Graaf, Piet H., Moerland, Matthijs, van Hasselt, Johan G. C.

“…Sepsis is a life-threatening condition driven by the dysregulation of the host immune response to an infection. The complex and interacting mechanisms…”
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Barriers to global pharmacometrics: educational challenges and opportunities across the globe by Michelet, Robin, Aulin, Linda B. S., Borghardt, Jens M., Costa, Teresa Dalla, Denti, Paolo, Ibarra, Manuel, Ma, Guangda, Meibohm, Bernd, Pillai, Goonaseelan (Colin), Schmidt, Stephan, Hennig, Stefanie, Kloft, Charlotte

“…[...]a symposium was held at WCoP2022, a hybrid event with approximately 300 participants worldwide, which aimed to share different perspectives on…”
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Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans by Aulin, Linda B. S., Valitalo, Pyry A., Rizk, Matthew L., Visser, Sandra A. G., Rao, Gauri, van der Graaf, Piet H., van Hasselt, J. G. Coen

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Bayesian framework for multi-source data integration-Application to human extrapolation from preclinical studies by Boulet, Sandrine, Ursino, Moreno, Michelet, Robin, Aulin, Linda BS, Kloft, Charlotte, Comets, Emmanuelle, Zohar, Sarah

“…In preclinical investigations, for example, in in vitro, in vivo, and in silico studies, the pharmacokinetic, pharmacodynamic, and toxicological…”
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Understanding Voriconazole Metabolism: A Middle-Out Physiologically-Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights by Saleh, Ayatallah, Schulz, Josefine, Schlender, Jan-Frederik, Aulin, Linda B. S., Konrad, Amrei-Pauline, Kluwe, Franziska, Mikus, Gerd, Huisinga, Wilhelm, Kloft, Charlotte, Michelet, Robin

“…Background and Objective Voriconazole (VRC), a broad-spectrum antifungal drug, exhibits nonlinear pharmacokinetics (PK) due to saturable metabolic processes,…”
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Biomarker‐Guided Individualization of Antibiotic Therapy by Aulin, Linda B.S., Lange, Dylan W., Saleh, Mohammed A.A., Graaf, Piet H., Völler, Swantje, Hasselt, J.G. Coen

“…Treatment failure of antibiotic therapy due to insufficient efficacy or occurrence of toxicity is a major clinical challenge, and is expected to become even…”
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Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens by Healy, Katie, Aulin, Linda B S, Freij, Urban, Ellerstad, Marie, Brückle, Lena, Hillmering, Helen, Svae, Tor-Einar, Broliden, Kristina, Gustafsson, Rasmus

“…Abstract Background Asymptomatic blood donors can transmit human parvovirus B19 (B19V). Methods We assessed the B19V prevalence among a large cohort of blood…”
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Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution by Liakopoulos, Apostolos, Aulin, Linda B S, Buffoni, Matteo, Fragkiskou, Efthymia, van Hasselt, J G C, Rozen, Daniel E

“…Collateral sensitivity (CS), which arises when resistance to one antibiotic increases sensitivity toward other antibiotics, offers treatment opportunities to…”
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Evaluating the prevalence of Hepatitis E virus infection in a large cohort of European blood donors, 2015–2018 by Healy, Katie, Freij, Urban, Ellerstad, Marie, Aulin, Linda B. S., Brückle, Lena, Hillmering, Helen, Chen, Margaret Sällberg, Gustafsson, Rasmus

“…Hepatitis E virus (HEV) is endemic in Europe. However, standardized methods for the surveillance of HEV viremia in the general population are lacking. This…”
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Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations by Aulin, Linda B. S., Tandar, Sebastian T., van Zijp, Torben, van Ballegooie, Etienne, van der Graaf, Piet H., Saleh, Mohammed A. A., Välitalo, Pyry, van Hasselt, J. G. Coen

“…Background and Objectives Prediction of antimicrobial target-site pharmacokinetics is of relevance to optimize treatment with antimicrobial agents. A…”
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A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy by Bindellini, Davide, Michelet, Robin, Aulin, Linda B S, Melin, Johanna, Neumann, Uta, Blankenstein, Oliver, Huisinga, Wilhelm, Whitaker, Martin J, Ross, Richard, Kloft, Charlotte

“…Congenital adrenal hyperplasia (CAH) is characterized by impaired adrenal cortisol production. Hydrocortisone (synthetic cortisol) is the drug-of-choice for…”
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Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations by Liu, Feiyan, Aulin, Linda B. S., Guo, Tingjie, Krekels, Elke H. J., Moerland, Matthijs, Graaf, Piet H., Hasselt, Johan G. C.

“…Clinical studies in healthy volunteers challenged with lipopolysaccharide (LPS), a constituent of the cell wall of Gram‐negative bacteria, represent a key…”
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Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia by Aulin, Linda B. S., Kleijburg, Anne, Moerland, Matthijs, van Hasselt, J. G. Coen

“…In this study, we describe the kinetics of a new potential inflammatory biomarker, presepsin, together with a panel of well-established biomarkers in a human…”
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Semi-mechanistic modeling of resistance development to β-lactam and β-lactamase-inhibitor combinations by Tandar, Sebastian T., Aulin, Linda B.S., Leemkuil, Eva M. J., Liakopoulos, Apostolos, van Hasselt, J. G. Coen

“…The use of β-lactam (BL) and β-lactamase inhibitor (BLI) combinations, such as piperacillin-tazobactam (PIP-TAZ) is an effective strategy to combat infections…”
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Unraveling the Effects of Acute Inflammation on Pharmacokinetics: A Model-Based Analysis Focusing on Renal Glomerular Filtration Rate and Cytochrome P450 3A4-Mediated Metabolism by Liu, Feiyan, Aulin, Linda B. S., Manson, Martijn L., Krekels, Elke H. J., van Hasselt, J. G. Coen

“…Background and Objectives Acute inflammation caused by infections or sepsis can impact pharmacokinetics. We used a model-based analysis to evaluate the effect…”
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Bayesian Framework for Multi-Source Data Integration -- Application to Human Extrapolation From Preclinical Studies by Boulet, Sandrine, Ursino, Moreno, Michelet, Robin, Aulin, Linda B. S, Kloft, Charlotte, Comets, Emmanuelle, Zohar, Sarah

“…In preclinical investigations, e.g. in in vitro, in vivo and in silico studies, the pharmacokinetic, pharmacodynamic and toxicological characteristics of a…”
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