Search Results - "Auley, Mark T Mc"

An evolutionary perspective of lifespan and epigenetic inheritance by Mc Auley, Mark T.

“…In the last decade epigenetics has come to the fore as a discipline which is central to biogerontology. Age associated epigenetic changes are routinely linked…”
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Dietary restriction and ageing: Recent evolutionary perspectives by Mc Auley, Mark T.

“…Dietary restriction (DR) represents one of the most robust interventions for extending lifespan. It is not known how DR increases lifespan. The prevailing…”
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A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth by Morgan, Amy E., Salcedo-Sora, J. Enrique, Mc Auley, Mark T.

“…Folate (vitamin B9) plays a central role in one-carbon metabolism in prokaryotes and eukaryotes. This pathway mediates the transfer of one-carbon units,…”
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Modelling the molecular mechanisms of aging by Mc Auley, Mark T, Guimera, Alvaro Martinez, Hodgson, David, Mcdonald, Neil, Mooney, Kathleen M, Morgan, Amy E, Proctor, Carole J

“…The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age. Although cells possess mechanisms to repair or…”
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Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease by Morgan, Amy E, Acutt, Katie D, Mc Auley, Mark T

“…There is a growing need for biomarkers which predict age-onset pathology. Although this is challenging, the methylome offers significant potential. Cancer is…”
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Computationally Modelling Cholesterol Metabolism and Atherosclerosis by Davies, Callum, Morgan, Amy E, Mc Auley, Mark T

“…Cardiovascular disease (CVD) is the leading cause of death globally. The underlying pathological driver of CVD is atherosclerosis. The primary risk factor for…”
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Computationally Modeling Lipid Metabolism and Aging: A Mini-review by Mc Auley, Mark T, Mooney, Kathleen M

“…One of the greatest challenges in biology is to improve the understanding of the mechanisms which underpin aging and how these affect health. The need to…”
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A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation by Mc Auley, Mark T, Wilkinson, Darren J, Jones, Janette J L, Kirkwood, Thomas B L

“…Global demographic changes have stimulated marked interest in the process of aging. There has been, and will continue to be, an unrelenting rise in the number…”
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The evolution of ageing: classic theories and emerging ideas by Mc Auley, Mark T.

“…Ageing is generally regarded as a non-adaptive by-product of evolution. Based on this premise three classic evolutionary theories of ageing have been proposed…”
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Mathematical modelling of metabolic regulation in aging by Auley, Mark T Mc, Mooney, Kathleen M, Angell, Peter J, Wilkinson, Stephen J

“…The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct…”
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LDL-C levels in older people: Cholesterol homeostasis and the free radical theory of ageing converge by Mc Auley, Mark T, Mooney, Kathleen M

“…Abstract The cardiovascular disease (CVD) risk factor, low density lipoprotein cholesterol (LDL-C) increases with age, up until the midpoint of life in males…”
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Computational modelling folate metabolism and DNA methylation: implications for understanding health and ageing by Mc Auley, Mark T, Mooney, Kathleen M, Salcedo-Sora, J Enrique

“…Abstract Dietary folates have a key role to play in health, as deficiencies in the intake of these B vitamins have been implicated in a wide variety of…”
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Disrupting folate metabolism reduces the capacity of bacteria in exponential growth to develop persisters to antibiotics by Morgan, Jasmine, Smith, Matthew, Mc Auley, Mark T, Enrique Salcedo-Sora, J

“…Bacteria can survive high doses of antibiotics through stochastic phenotypic diversification. We present initial evidence that folate metabolism could be…”
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Aging and computational systems biology by Mooney, Kathleen M., Morgan, Amy E., Mc Auley, Mark T.

“…Aging research is undergoing a paradigm shift, which has led to new and innovative methods of exploring this complex phenomenon. The systems biology approach…”
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A mathematical model of microbial folate biosynthesis and utilisation: implications for antifolate development by Salcedo-Sora, J Enrique, Mc Auley, Mark T

“…The metabolic biochemistry of folate biosynthesis and utilisation has evolved into a complex network of reactions. Although this complexity represents…”
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Computational systems biology for aging research by Mc Auley, Mark T, Mooney, Kathleen M

“…Computational modelling is a key component of systems biology and integrates with the other techniques discussed thus far in this book by utilizing a myriad of…”
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