Search Results - "Auld, Vanessa J."

A Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin Receptor by Padash Barmchi, Mojgan, Gilbert, Mary, Thomas, Miranda, Banks, Lawrence, Zhang, Bing, Auld, Vanessa J

“…Cervical cancer is one of the leading causes of cancer death in women worldwide. The causative agents of cervical cancers, high-risk human papillomaviruses…”
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Magi Is Associated with the Par Complex and Functions Antagonistically with Bazooka to Regulate the Apical Polarity Complex by Padash Barmchi, Mojgan, Samarasekera, Gayathri, Gilbert, Mary, Auld, Vanessa J, Zhang, Bing

“…The mammalian MAGI proteins play important roles in the maintenance of adherens and tight junctions. The MAGI family of proteins contains modular domains such…”
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Glial processes at the Drosophila larval neuromuscular junction match synaptic growth by Brink, Deidre L, Gilbert, Mary, Xie, Xiaojun, Petley-Ragan, Lindsay, Auld, Vanessa J

“…Glia are integral participants in synaptic physiology, remodeling and maturation from blowflies to humans, yet how glial structure is coordinated with synaptic…”
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Gliotactin, a Novel Marker of Tricellular Junctions, Is Necessary for Septate Junction Development in Drosophila by Schulte, Joost, Tepass, Ulrich, Auld, Vanessa J.

“…Septate junctions (SJs), similar to tight junctions, function as transepithelial permeability barriers. Gliotactin (Gli) is a cholinesterase-like molecule that…”
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Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia by Padash-Barmchi, Mojgan, Browne, Kristen, Sturgeon, Kendra, Jusiak, Barbara, Auld, Vanessa J

“…The tricellular junction (TCJ) forms at the convergence of bicellular junctions from three adjacent cells in polarized epithelia and is necessary for…”
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Innexin-Mediated Adhesion between Glia Is Required for Axon Ensheathment in the Peripheral Nervous System by Das, Mriga, Cheng, Duo, Matzat, Till, Auld, Vanessa J

“…Glia are essential to protecting and enabling nervous system function and a key glial function is the formation of the glial sheath around peripheral axons…”
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Scribble and Discs-large mediate tricellular junction formation by Sharifkhodaei, Zohreh, Gilbert, Mary M, Auld, Vanessa J

“…Junctional complexes that mediate cell adhesion are key to epithelial integrity, cell division and permeability barriers formation. In the scaffolding proteins…”
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Integrins are necessary for the development and maintenance of the glial layers in the Drosophila peripheral nerve by Xie, Xiaojun, Auld, Vanessa J

“…Peripheral nerve development involves multiple classes of glia that cooperate to form overlapping glial layers paired with the deposition of a surrounding…”
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RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia by Sepp, Katharine J, Auld, Vanessa J

“…Peripheral glial cells in both vertebrates and insects are born centrally and travel large distances to ensheathe axons in the periphery. There is very little…”
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Basigin Associates with Integrin in Order to Regulate Perineurial Glia and Drosophila Nervous System Morphology by Hunter, Amelia C, Petley-Ragan, Lindsay M, Das, Mriga, Auld, Vanessa J

“…The nervous system is ensheathed by a layer of outer glial cells, the perineurial glia, and a specialized extracellular matrix, the neural lamella. The…”
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Loss of focal adhesions in glia disrupts both glial and photoreceptor axon migration in the Drosophila visual system by Xie, Xiaojun, Gilbert, Mary, Petley-Ragan, Lindsay, Auld, Vanessa J

“…Many aspects of glial development are regulated by extracellular signals, including those from the extracellular matrix (ECM). Signals from the ECM are…”
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Conversion of lacZ enhancer trap lines to GAL4 lines using targeted transposition in Drosophila melanogaster by Sepp, K.J. (University of British Columbia, Vancouver, BC, Canada.), Auld, V.J

“…Since the development of the enhancer trap technique, many large libraries of nuclear localized lacZ P-element stocks have been generated. These lines can lend…”
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Accumulation of Laminin Monomers in Drosophila Glia Leads to Glial Endoplasmic Reticulum Stress and Disrupted Larval Locomotion by Petley-Ragan, Lindsay M, Ardiel, Evan L, Rankin, Catharine H, Auld, Vanessa J

“…The nervous system is surrounded by an extracellular matrix composed of large glycoproteins, including perlecan, collagens, and laminins. Glial cells in many…”
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Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in drosophila by Auld, Vanessa J, Fetter, Richard D, Broadie, Kendal, Goodman, Corey S

“…Peripheral glia help ensure that motor and sensory axons are bathed in the appropriate ionic and biochemical environment. In Drosophila, peripheral glia help…”
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Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia by Gilbert, Mary, Smith, Jeff, Roskams, Angela-Jane, Auld, Vanessa J.

“…The molecular mechanisms that drive glia–glial interactions and glia–neuronal interactions during the development of the nervous system are poorly understood…”
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Gliotactin and Discs large are co-regulated to maintain epithelial integrity by Padash-Barmchi, Mojgan, Charish, Kristi, Que, Jammie, Auld, Vanessa J

“…Establishment and maintenance of permeability barriers is one of the most important functions of epithelial cells. Tricellular junctions (TCJs) maintain the…”
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The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184 by Sharifkhodaei, Zohreh, Padash-Barmchi, Mojgan, Gilbert, Mary M, Samarasekera, Gayathri, Fulga, Tudor A, Van Vactor, David, Auld, Vanessa J

“…Epithelial bicellular and tricellular junctions are essential for establishing and maintaining permeability barriers. Tricellular junctions are formed by the…”
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Peripheral Glia Direct Axon Guidance across the CNS/PNS Transition Zone by Sepp, Katharine J., Schulte, Joost, Auld, Vanessa J.

“…CNS glia have integral roles in directing axon migration of both vertebrates and insects. In contrast, very little is known about the roles of PNS glia in…”
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Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila by Schulte, Joost, Charish, Kristi, Que, Jaimmie, Ravn, Sarah, MacKinnon, Christina, Auld, Vanessa J

“…The tricellular junction (TCJ) forms at the convergence of pleated septate junctions (SJs) from three adjacent cells in polarized epithelia and is necessary…”
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Roles of glia in the Drosophila nervous system by Parker, Robert J., Auld, Vanessa J.

“…Glial cells have diverse functions that are necessary for the proper development and function of complex nervous systems. Various insects, primarily the fruit…”
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