Search Results - "Auld, D S"

Medium- and short-chain dehydrogenase/reductase gene and protein families: The role of zinc for alcohol dehydrogenase structure and function by Auld, D. S., Bergman, T.

“… Zinc plays an important role in the structure and function of many enzymes, including alcohol dehydrogenases (ADHs) of the MDR type (mediumchain…”
Get full text

Glial Cells and Neurotransmission: An Inclusive View of Synaptic Function by Auld, Daniel S, Robitaille, Richard

“…Glial cells throughout the nervous system are closely associated with synapses. Accompanying these anatomical couplings are intriguing functional interactions,…”
Get full text

Amyloid β‐Peptide Inhibits High‐Affinity Choline Uptake and Acetylcholine Release in Rat Hippocampal Slices by Kar, S., Issa, A. M., Seto, D., Auld, D. S., Collier, B., Quirion, R.

“…: The characteristic pathological features of the postmortem brain of Alzheimer's disease (AD) patients include, among other features, the presence of neuritic…”
Get full text

β-Amyloid peptides as direct cholinergic neuromodulators: a missing link? by Auld, Daniel S., Kar, Satyabrata, Quirion, Rémi

“…β-Amyloid peptide (Aβ) is found in diffuse and focal deposits throughout the brain from Alzheimer's disease (AD) patients. Another feature of AD is the…”
Get full text

Zinc binding to peptide analogs of the structural zinc site in alcohol dehydrogenase: Implications for an entatic state by Bergman, T., Zhang, K., Palmberg, C., Jörnvall, H., Auld, D. S.

“… Zinc binding to the peptide replica and analogs to residues 93–15 of horse liver alcohol dehydrogenase (ADH) was examined by competition of the peptides and…”
Get full text

Active-site zinc ligands and activated H2O of zinc enzymes by VALLEE, B. L, AULD, D. S

“…The x-ray crystallographic structures of 12 zinc enzymes have been chosen as standards of reference to identify the ligands to the catalytic and structural…”
Get full text

Zinc coordination, function, and structure of zinc enzymes and other proteins by Vallee, Bert L, Auld, David S

“…A perspective on the biological occurrence and role of zinc should not only seek out the generalizations that are now apparent but should also call attention…”
Get full text

Cocatalytic Zinc Motifs in Enzyme Catalysis by Vallee, Bert L., Auld, David S.

“…Cocatalytic zinc binding sites are characteristic of enzyme molecules which contain two or more zinc and/or other metal atoms. In each site an aspartate,…”
Get full text

Zinc Fingers, Zinc Clusters, and Zinc Twists in DNA-Binding Protein Domains by Vallee, Bert L., Coleman, Joseph E., Auld, David S.

“…We now recognize three distinct motifs of DNA-binding zinc proteins: (i) zinc fingers, (ii) zinc clusters, and (iii) zinc twists. Until very recently, x-ray…”
Get full text

New perspective on zinc biochemistry: Cocatalytic sites in multi-zinc enzymes by Vallee, Bert L, Auld, David S

“…Our first perspective on zinc binding sites in biology focused on the zinc coordination, function, and structure of mono-zinc enzymes and the existing limited…”
Get full text

Zinc coordination sphere in biochemical zinc sites by Auld, D S

“…Zinc is known to be indispensable to growth and development and transmission of the genetic message. It does this through a remarkable mosaic of zinc binding…”
Get full text

The role of zinc for alcohol dehydrogenase structure and function by Auld, DS, Bergman, T

Get full text

Site-Directed Mutagenesis of the Active Site Glutamate in Human Matrilysin:  Investigation of Its Role in Catalysis by Cha, Jaeho, Auld, David S

“…Glu-198 of human matrilysin is a conserved residue in the matrix metalloproteinases and is considered to play an important role in catalysis by acting as a…”
Get full text

Discrete Determinants in Transfer RNA for Editing and Aminoacylation by Hale, Stephen P., Auld, Douglas S., Schmidt, Eric, Schimmel, Paul

“…During translation errors of aminoacylation are corrected in editing reactions which ensure that an amino acid is stably attached to its corresponding transfer…”
Get full text

Switching Recognition of Two tRNA Synthetases with an Amino Acid Swap in a Designed Peptide by Auld, Douglas S., Schimmel, Paul

“…The genetic code is based on specific interactions between transfer RNA (tRNA) synthetases and their cognate tRNAs. The anticodons for methionine and…”
Get full text

Characterization of an inhibitory metal binding site in carboxypeptidase A by Larsen, Kjeld S, Auld, David S

“…The specificity of metal ion inhibition of bovine carboxypeptidase A ([(CPD)Zn]) catalysis is examined under stopped-flow conditions with use of the…”
Get full text

Voltage-Gated Channels Formed in Lipid Bilayers by a Positively Charged Segment of the Na-Channel Polypeptide by Tosteson, Magdalena T., Auld, David S., Tosteson, Daniel C.

“…The Na-channel polypeptide is responsible for the voltage-gated and time-dependent ionic permeability changes that give rise to the action potential in the…”
Get full text

Carboxypeptidase A: mechanism of zinc inhibition by Larsen, Kjeld S, Auld, David S

“…Zinc ions competitively inhibit carboxypeptidase A from bovine pancreas. The state(s) of hydroxylation of zinc and their possible site(s) of interaction with…”
Get full text

Single sequence of a helix‐loop peptide confers functional anticodon recognition on two tRNA synthetases by Auld, D. S., Schmimmel, P.

“…The specific aminoacylation of RNA oligonucleotides whose sequences are based on the acceptor stems of tRNAs can be viewed as an operational RNA code for amino…”
Get full text

Short and long spacer sequences and other structural features of zinc binding sites in zinc enzymes by Vallee, Bert L., Auld, David S.

“…The crystal structures of eleven zinc enzymes have served to identify common features of their Zn binding sites. Two of them have non-catalytic Zn sites, both…”
Get full text