Search Results - "Aukema, Robert J."

Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice by Mayo, Leah M., Asratian, Anna, Lindé, Johan, Holm, Lovisa, Nätt, Daniel, Augier, Gaëlle, Stensson, Niclas, Vecchiarelli, Haley A., Balsevich, Georgia, Aukema, Robert J., Ghafouri, Bijar, Spagnolo, Primavera A., Lee, Francis S., Hill, Matthew N., Heilig, Markus

“…Post-traumatic stress disorder (PTSD) is a common, debilitating condition with limited treatment options. Extinction of fear memories through prolonged…”
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Upregulation of Anandamide Hydrolysis in the Basolateral Complex of Amygdala Reduces Fear Memory Expression and Indices of Stress and Anxiety by Morena, Maria, Aukema, Robert J, Leitl, Kira D, Rashid, Asim J, Vecchiarelli, Haley A, Josselyn, Sheena A, Hill, Matthew N

“…Increased anandamide (AEA) signaling through inhibition of its catabolic enzyme fatty acid amide hydrolase (FAAH) in the basolateral complex of amygdala (BLA)…”
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Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats by Baglot, Samantha L., Hume, Catherine, Petrie, Gavin N., Aukema, Robert J., Lightfoot, Savannah H. M., Grace, Laine M., Zhou, Ruokun, Parker, Linda, Rho, Jong M., Borgland, Stephanie L., McLaughlin, Ryan J., Brechenmacher, Laurent, Hill, Matthew N.

“…Up to a third of North Americans report using cannabis in the prior month, most commonly through inhalation. Animal models that reflect human consumption are…”
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A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice by Balsevich, Georgia, Petrie, Gavin N, Heinz, Daniel E, Singh, Arashdeep, Aukema, Robert J, Hunker, Avery C, Vecchiarelli, Haley A, Yau, Hiulan, Sticht, Martin, Thompson, Roger J, Lee, Francis S, Zweifel, Larry S, Chelikani, Prasanth K, Gassen, Nils C, Hill, Matthew N

“…Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in (FAAH C385A) reduces FAAH expression, increases anandamide levels,…”
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Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice by Vecchiarelli, Haley A, Aukema, Robert J, Hume, Catherine, Chiang, Vincent, Morena, Maria, Keenan, Catherine M, Nastase, Andrei S, Lee, Francis S, Pittman, Quentin J, Sharkey, Keith A, Hill, Matthew N

“…Cannabinoids, including derived phytocannabinoids and endogenous cannabinoids (endocannabinoids), are typically considered anti-inflammatory. One such…”
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Sex and stressor modality influence acute stress-induced dynamic changes in corticolimbic endocannabinoid levels in adult Sprague Dawley rats by Vecchiarelli, Haley A., Morena, Maria, Lee, Tiffany T.Y., Nastase, Andrei S., Aukema, Robert J., Leitl, Kira D., Gray, J. Megan, Petrie, Gavin N., Tellez-Monnery, Kristin J., Hill, Matthew N.

“…Research over the past few decades has established a role for the endocannabinoid system in contributing to the neural and endocrine responses to stress…”
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Endocannabinoids, cannabinoids and the regulation of anxiety by Petrie, Gavin N., Nastase, Andrei S., Aukema, Robert J., Hill, Matthew N.

“…Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety often reported as a primary reason for use. Only recently has the…”
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Circadian Influence on Acute Stress-induced Changes in Cortico-limbic Endocannabinoid Levels in Adult Male Rats by Aukema, Robert J, Baglot, Samantha L, Scheufen, Jessica, Lightfoot, Savannah Hm, Hill, Matthew N

“…The endocannabinoid (eCB) system plays an important role in regulating the stress response, including glucocorticoid release and the generation of avoidance…”
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Identification of a stress-responsive subregion of the basolateral amygdala in male rats by Aukema, Robert J., Petrie, Gavin N., Matarasso, Avi K., Baglot, Samantha L., Molina, Leonardo A., Füzesi, Tamás, Kadhim, Sandra, Nastase, Andrei S., Rodriguez Reyes, Itzel, Bains, Jaideep S., Morena, Maria, Bruchas, Michael R., Hill, Matthew N.

“…The basolateral amygdala (BLA) is reliably activated by psychological stress and hyperactive in conditions of pathological stress or trauma; however, subsets…”
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Disruption of tonic endocannabinoid signalling triggers cellular, behavioural and neuroendocrine responses consistent with a stress response by Petrie, Gavin N., Balsevich, Georgia, Füzesi, Tamás, Aukema, Robert J., Driever, Wouter P. F., Stelt, Mario, Bains, Jaideep S., Hill, Matthew N.

“…Background and Purpose Endocannabinoid (eCB) signalling gates many aspects of the stress response, including the hypothalamic–pituitary–adrenal (HPA) axis. The…”
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Maternal‐fetal transmission of delta‐9‐tetrahydrocannabinol (THC) and its metabolites following inhalation and injection exposure during pregnancy in rats by Baglot, Samantha L., VanRyzin, Jonathan W., Marquardt, Ashley E., Aukema, Robert J., Petrie, Gavin N., Hume, Catherine, Reinl, Erin L., Bieber, John B., McLaughlin, Ryan J., McCarthy, Margaret M., Hill, Matthew N.

“…Cannabis use during pregnancy has increased over the past few decades, with recent data indicating that, in youth and young adults especially, up to 22% of…”
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Acute stress activates basolateral amygdala neurons expressing corticotropin-releasing hormone receptor type 1 (CRHR1): Topographical distribution and projection-specific activation in male and female rats by Aukema, Robert J., Petrie, Gavin N., Baglot, Samantha L., Gilpin, Nicholas W., Hill, Matthew N.

“…Although the basolateral amygdala (BLA) and corticotropin releasing hormone receptor type I (CRHR1) signaling are both central to the stress response, the…”
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