Search Results - "Aukema, Harold"

Prostaglandins as potential targets for the treatment of polycystic kidney disease by Aukema, Harold M.

“…•Polycystic kidneys have higher epithelial cell proliferation and fluid-filled cysts.•cAMP stimulates both cell proliferation and fluid secretion in polycystic…”
Get full text

Dietary ALA, EPA and DHA have distinct effects on oxylipin profiles in female and male rat kidney, liver and serum by Leng, Shan, Winter, Tanja, Aukema, Harold M.

“…There is much data on the effects of dietary n-3 fatty acids on tissue fatty acid compositions, but comparable comprehensive data on their oxygenated…”
Get full text

Nutritional and health benefits of pulses by Mudryj, Adriana N, Yu, Nancy, Aukema, Harold M

“…Pulses (beans, peas, and lentils) have been consumed for at least 10 000 years and are among the most extensively used foods in the world. A wide variety of…”
Get more information

Phospholipase A2 enzymes differently impact PUFA release and oxylipin formation ex vivo in rat hearts by Manson, Anne, Winter, Tanja, Aukema, Harold M.

“…•sPLA2 enzymes mediate DHA release and oxylipin formation in rat hearts.•iPLA2 enzymes are likely responsible for other PUFA release and oxylipin…”
Get full text

Factors affecting variability in free oxylipins in mammalian tissues by Aukema, Harold M., Ravandi, Amir

“…Along with the growing interest in oxylipins is an increasing awareness of multiple sources of variability in oxylipin data. This review summarizes recent…”
Get full text

Time Course and Sex Effects of α-Linolenic Acid-Rich and DHA-Rich Supplements on Human Plasma Oxylipins: A Randomized Double-Blind Crossover Trial by Gabbs, Melissa, Zahradka, Peter, Taylor, Carla G, Aukema, Harold M

“…Differences in health effects of dietary α-linolenic acid (ALA) and DHA are mediated at least in part by differences in their effects on oxylipins. Time course…”
Get more information

Dietary LA and sex effects on oxylipin profiles in rat kidney, liver, and serum differ from their effects on PUFAs by Leng, Shan, Winter, Tanja, Aukema, Harold M.

“…A vast literature on fatty acids in mammals exists, but comparable compositional data on oxylipins is lacking. Weanling Sprague-Dawley rats were therefore…”
Get full text

Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease by Devassy, Jessay Gopuran, Leng, Shan, Gabbs, Melissa, Monirujjaman, Md, Aukema, Harold M

“…Alzheimer disease (AD) is becoming one of the most prevalent neurodegenerative conditions worldwide. Although the disease progression is becoming better…”
Get full text

High Dietary Protein Does Not Alter Renal Prostanoids and Other Oxylipins in Normal Mice or in Those with Inherited Kidney Disease by Monirujjaman, Md, Aukema, Harold M

“…Ex vivo studies suggest that increased renal prostanoids can mediate effects of high-protein (HP) compared with low-protein (LP) diets on normal and diseased…”
Get more information

Anti-inflammatory effects of α-linolenic acid in M1-like macrophages are associated with enhanced production of oxylipins from α-linolenic and linoleic acid by Pauls, Samantha D, Rodway, Lisa A, Winter, Tanja, Taylor, Carla G, Zahradka, Peter, Aukema, Harold M

“…Chronic inflammation, mediated in large part by proinflammatory macrophage populations, contributes directly to the induction and perpetuation of metabolic…”
Get full text

PD146176 affects human EA.hy926 endothelial cell function by differentially modulating oxylipin production of LOX, COX and CYP epoxygenase by Du, Youjia, Taylor, Carla G., Aukema, Harold M., Zahradka, Peter

“…Oxylipins are oxygenated derivatives of polyunsaturated fatty acids, generated by COX, LOX and CYP enzymes, that regulate various aspects of endothelial cell…”
Get full text

Dietary modulation of oxylipins in cardiovascular disease and aging by Caligiuri, Stephanie P B, Parikh, Mihir, Stamenkovic, Aleksandra, Pierce, Grant N, Aukema, Harold M

“…Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated fatty acids and are involved in processes such as inflammation,…”
Get more information

Dietary n-6 and n-3 PUFA alter the free oxylipin profile differently in male and female rat hearts by Ferdouse, Afroza, Leng, Shan, Winter, Tanja, Aukema, Harold M.

“…Oxylipins are bioactive lipid mediators synthesised from PUFA. The most well-known oxylipins are the eicosanoids derived from arachidonic acid (ARA), and many…”
Get full text

The Brain Oxylipin Profile Is Resistant to Modulation by Dietary n‐6 and n‐3 Polyunsaturated Fatty Acids in Male and Female Rats by Ferdouse, Afroza, Leng, Shan, Winter, Tanja, Aukema, Harold M.

“…Oxylipins are bioactive lipids formed by the monooxygenation of polyunsaturated fatty acids (PUFA). Eicosanoids derived from arachidonic acid (ARA) are the…”
Get full text

Regulation of docosahexaenoic acid-induced apoptosis of confluent endothelial cells: Contributions of MAPKs and caspases by Du, Youjia, Taylor, Carla G., Aukema, Harold M., Zahradka, Peter

“…Endothelial cells, which help to maintain vascular homeostasis, can be functionally modulated by polyunsaturated fatty acids. Previously, we reported that…”
Get full text

Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health by Pauls, Samantha D., Du, Youjia, Clair, Luc, Winter, Tanja, Aukema, Harold M., Taylor, Carla G., Zahradka, Peter

“…Cardiovascular disease, a major cause of mortality and morbidity, exhibits sexual dimorphism since the onset of cardiovascular disease occurs later in women…”
Get full text

Species-specific oxylipins and the effects of ontogeny and predation on their emission from freshwater snails by Friesen, Olwyn C., Aukema, Harold M., Detwiler, Jillian T.

“…Chemical cues play important roles in mediating ecological interactions. Oxylipins, oxygenated metabolites of fatty acids, are one signalling molecule type…”
Get full text

Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis by Cayer, Lucien G J, Surendran, Arun, Karakach, Tobias, Aukema, Harold M, Ravandi, Amir

“…Aortic valve stenosis (AVS) is the most common valvular disease in the developed world. AVS involves the progressive fibrocalcific remodeling of the aortic…”
Get full text

Role of oxylipins generated from dietary PUFAs in the modulation of endothelial cell function by Du, Youjia, Taylor, Carla G., Aukema, Harold M., Zahradka, Peter

“…•Summary of effects of oxylipins on endothelial cells in vitro, ex vivo & in vivo.•Describes key mechanisms by which oxylipins modulate endothelial cell…”
Get full text

Cardiac oxylipin perturbances in response to 2-monochloropropane-1,3-diol exposure are ameliorated by dietary adequacy of the essential n-3 fatty acid, α-linolenic acid by Cayer, Lucien GJ, Karakach, Tobias, Roberts, Jennifer, Brooks, Stephen PJ, Raju, Jayadev, Aukema, Harold M.

“…2-Monochloropropane-1,3-diol (2-MCPD) is a food contaminant with demonstrated cardiotoxicity in rats. This adverse effect was previously associated with lower…”
Get full text