Arboviral Infections in Neurological Disorders in Hospitalized Patients in São José do Rio Preto, São Paulo, Brazil

Arbovirus infections are increasingly important causes of disease, whose spectrum of neurological manifestations are not fully known. This study sought to retrospectively assess the incidence of arboviruses in cerebrospinal fluid samples of patients with neurological symptoms to inform diagnosis of...

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Bibliographic Details
Published in:	Viruses Vol. 14; no. 7; p. 1488
Main Authors:	Milhim, Bruno H G A, da Rocha, Leonardo C, Terzian, Ana C B, Mazaro, Carolina C P, Augusto, Marcos T, Luchs, Adriana, Zini, Nathalia, Sacchetto, Livia, Dos Santos, Barbara F, Garcia, Pedro H C, Rocha, Rodrigo S, Liso, Elisabete, Brienze, Vânia M S, da Silva, Gislaine C D, Vasilakis, Nikos, Estofolete, Cássia F, Nogueira, Maurício L
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 07-07-2022 MDPI
Subjects:	Adolescent Adult Aged Antibodies arbovirus Arbovirus diseases Arbovirus Infections - epidemiology Arboviruses - genetics Arthropods Brazil - epidemiology Care and treatment Cerebrospinal fluid Chikungunya Fever Dengue Dengue fever Diagnosis Encephalitis Guillain-Barre syndrome Hospital patients Hospitalization Humans Illnesses Infections Laboratories Meningitis Middle Aged Nervous system Nervous system diseases Nervous System Diseases - complications Nervous System Diseases - epidemiology Neurological diseases Neurological disorders Patients Polymerase chain reaction Public health Retrospective Studies Serology surveillance Viral infections Viruses Young Adult Zika virus Zika Virus - genetics Zika Virus Infection Brazil South America United States > US Germany neurological disorders surveillance arbovirus
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Summary:	Arbovirus infections are increasingly important causes of disease, whose spectrum of neurological manifestations are not fully known. This study sought to retrospectively assess the incidence of arboviruses in cerebrospinal fluid samples of patients with neurological symptoms to inform diagnosis of central and peripheral nervous system disorders. A total of 255 cerebrospinal fluid (CSF) samples collected from January 2016 to December 2017 were tested for dengue virus (DENV 1-4), Zika virus (ZIKV), and Chikungunya virus (CHIKV) in addition to other neurotropic arboviruses of interest, using genetic and serologic assays. Of the 255 CSF samples analyzed, 3.53% (09/255) were positive for arboviruses presenting mainly as meningitis, encephalitis, and cerebrovascular events, of which ZIKV was detected in 2.74% (7/255), DENV in 0.78% (2/255), in addition to an identified ILHV infection that was described previously. All the cases were detected in adults aged 18 to 74 years old. Our findings highlight the scientific and clinical importance of neurological syndromes associated with arboviruses and demonstrate the relevance of specific laboratory methods to achieve accurate diagnoses as well as highlight the true dimension of these diseases to ultimately improve public health planning and medical case management.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v14071488