Search Results - "Augustine, George J."

In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2 by Arenkiel, Benjamin R., Peca, Joao, Davison, Ian G., Feliciano, Catia, Deisseroth, Karl, Augustine, George J., Ehlers, Michael D., Feng, Guoping

“…Channelrhodopsin-2 (ChR2) is a light-gated, cation-selective ion channel isolated from the green algae Chlamydomonas reinhardtii. Here, we report the…”
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The cerebellum and anxiety by Chin, Pei Wern, Augustine, George J

“…Although the cerebellum is traditionally known for its role in motor functions, recent evidence points toward the additional involvement of the cerebellum in…”
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Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity by Heiney, Shane A, Kim, Jinsook, Augustine, George J, Medina, Javier F

“…Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these…”
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Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses by Song, Sang-Ho, Augustine, George J.

“…Synapsins cluster synaptic vesicles (SVs) to provide a reserve pool (RP) of SVs that maintains synaptic transmission during sustained activity. However, it is…”
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Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking by Chen, Susu, Augustine, George J., Chadderton, Paul

“…Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are…”
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Synapsins and the Synaptic Vesicle Reserve Pool: Floats or Anchors? by Zhang, Minchuan, Augustine, George J

“…In presynaptic terminals, synaptic vesicles (SVs) are found in a discrete cluster that includes a reserve pool that is mobilized during synaptic activity…”
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Light-emitting channelrhodopsins for combined optogenetic and chemical-genetic control of neurons by Berglund, Ken, Birkner, Elisabeth, Augustine, George J, Hochgeschwender, Ute

“…Manipulation of neuronal activity through genetically targeted actuator molecules is a powerful approach for studying information flow in the brain. In these…”
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Channel-Mediated Tonic GABA Release from Glia by Lee, Soojung, Yoon, Bo-Eun, Berglund, Ken, Oh, Soo-Jin, Park, Hyungju, Shin, Hee-Sup, Augustine, George J, Lee, C. Justin

“…Synaptic inhibition is based on both tonic and phasic release of the inhibitory transmitter γ-aminobutyric acid (GABA). Although phasic GABA release arises…”
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Topologically Organized Networks in the Claustrum Reflect Functional Modularization by Ham, Gao Xiang, Augustine, George J.

“…Using genetic strategies and viral-based directional tracers, we investigated the topological location and output networks of claustrum (CLA) neuron…”
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Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum by Rowan, Matthew J.M., Bonnan, Audrey, Zhang, Ke, Amat, Samantha B., Kikuchi, Chikako, Taniguchi, Hiroki, Augustine, George J., Christie, Jason M.

“…Purkinje cell dendrites convert excitatory climbing fiber input into signals that instruct plasticity and motor learning. Modulation of instructive signaling…”
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Synchrony in parent‐offspring social interactions across development: A cross‐species review of rodents and humans by Ham, Gao Xiang, Lim, Kai En, Augustine, George J., Leong, Victoria

“…In humans, parent–child neural synchrony has been shown to support early communication, social attunement and learning. Further, some animal species (including…”
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The cerebellum linearly encodes whisker position during voluntary movement by Chen, Susu, Augustine, George J, Chadderton, Paul

“…Active whisking is an important model sensorimotor behavior, but the function of the cerebellum in the rodent whisker system is unknown. We have made patch…”
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Social memory deficit caused by dysregulation of the cerebellar vermis by Chao, Owen Y., Pathak, Salil Saurav, Zhang, Hao, Augustine, George J., Christie, Jason M., Kikuchi, Chikako, Taniguchi, Hiroki, Yang, Yi-Mei

“…Social recognition memory (SRM) is a key determinant of social interactions. While the cerebellum emerges as an important region for social behavior, how…”
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A Positive Feedback Signal Transduction Loop Determines Timing of Cerebellar Long-Term Depression by Tanaka, Keiko, Augustine, George J.

“…Synaptic activity produces short-lived second messengers that ultimately yield a long-term depression (LTD) of cerebellar Purkinje cells. Here, we test the…”
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Structural basis for delta cell paracrine regulation in pancreatic islets by Arrojo e Drigo, Rafael, Jacob, Stefan, García-Prieto, Concha F., Zheng, Xiaofeng, Fukuda, Masahiro, Nhu, Hoa Tran Thi, Stelmashenko, Olga, Peçanha, Flavia Letícia Martins, Rodriguez-Diaz, Rayner, Bushong, Eric, Deerinck, Thomas, Phan, Sebastien, Ali, Yusuf, Leibiger, Ingo, Chua, Minni, Boudier, Thomas, Song, Sang-Ho, Graf, Martin, Augustine, George J., Ellisman, Mark H., Berggren, Per-Olof

“…Little is known about the role of islet delta cells in regulating blood glucose homeostasis in vivo. Delta cells are important paracrine regulators of beta…”
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Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells by Xu, Xiaohong, Tay, Yilin, Sim, Bernice, Yoon, Su-In, Huang, Yihui, Ooi, Jolene, Utami, Kagistia Hana, Ziaei, Amin, Ng, Bryan, Radulescu, Carola, Low, Donovan, Ng, Alvin Yu Jin, Loh, Marie, Venkatesh, Byrappa, Ginhoux, Florent, Augustine, George J., Pouladi, Mahmoud A.

“…Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG repeat expansion in HTT. Here we report correction of HD human induced…”
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Selective Control of Fear Expression by Optogenetic Manipulation of Infralimbic Cortex after Extinction by Kim, Hyung-Su, Cho, Hye-Yeon, Augustine, George J, Han, Jin-Hee

“…Evidence from rodent and human studies has identified the ventromedial prefrontal cortex, specifically the infralimbic cortex (IL), as a critical brain…”
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Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation by Berglund, Ken, Clissold, Kara, Li, Haofang E., Wen, Lei, Park, Sung Young, Gleixner, Jan, Klein, Marguerita E., Lu, Dongye, Barter, Joseph W., Rossi, Mark A., Augustine, George J., Yin, Henry H., Hochgeschwender, Ute

“…Luminopsins are fusion proteins of luciferase and opsin that allow interrogation of neuronal circuits at different temporal and spatial resolutions by choosing…”
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Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles by Longfield, Shanley F., Gormal, Rachel S., Feller, Matis, Parutto, Pierre, Reingruber, Jürgen, Wallis, Tristan P., Joensuu, Merja, Augustine, George J., Martínez-Mármol, Ramón, Holcman, David, Meunier, Frédéric A.

“…Neurotransmitter release relies on the regulated fusion of synaptic vesicles (SVs) that are tightly packed within the presynaptic bouton of neurons. The…”
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Optogenetic Mapping of Cerebellar Inhibitory Circuitry Reveals Spatially Biased Coordination of Interneurons via Electrical Synapses by Kim, Jinsook, Lee, Soojung, Tsuda, Sachiko, Zhang, Xuying, Asrican, Brent, Gloss, Bernd, Feng, Guoping, Augustine, George J.

“…We used high-speed optogenetic mapping technology to examine the spatial organization of local inhibitory circuits formed by cerebellar interneurons…”
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