Search Results - "Augustin, Hrvoje"

Myostatin-like proteins regulate synaptic function and neuronal morphology by Augustin, Hrvoje, McGourty, Kieran, Steinert, Joern R, Cochemé, Helena M, Adcott, Jennifer, Cabecinha, Melissa, Vincent, Alec, Halff, Els F, Kittler, Josef T, Boucrot, Emmanuel, Partridge, Linda

“…Growth factors of the TGFβ superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators…”
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Potential benefits of medium chain fatty acids in aging and neurodegenerative disease by Dunn, Ella, Zhang, Biqin, Sahota, Virender K., Augustin, Hrvoje

“…Neurodegenerative diseases are a large class of neurological disorders characterized by progressive dysfunction and death of neurones. Examples include…”
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Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies by Augustin, Hrvoje, McGourty, Kieran, Allen, Marcus J, Madem, Sirisha Kudumala, Adcott, Jennifer, Kerr, Fiona, Wong, Chi Tung, Vincent, Alec, Godenschwege, Tanja, Boucrot, Emmanuel, Partridge, Linda

“…Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects…”
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Plum modulates Myoglianin and regulates synaptic function in D. melanogaster by Sahota, Virender K., Stone, Aelfwin, Woodling, Nathaniel S., Spiers, Jereme G., Steinert, Joern R., Partridge, Linda, Augustin, Hrvoje

“…Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss…”
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A glial amino-acid transporter controls synapse strength and courtship in Drosophila by Featherstone, David E, Grosjean, Yael, Augustin, Hrvoje, Ferveur, Jean-François, Grillet, Micheline

“…Mate choice is an evolutionarily critical decision that requires the detection of multiple sex-specific signals followed by central integration of these…”
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Medium-Chain Fatty Acids Rescue Motor Function and Neuromuscular Junction Degeneration in a Drosophila Model of Amyotrophic Lateral Sclerosis by Dunn, Ella, Steinert, Joern R., Stone, Aelfwin, Sahota, Virender, Williams, Robin S. B., Snowden, Stuart, Augustin, Hrvoje

“…Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterised by progressive degeneration of the motor neurones. An expanded…”
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Complex roles of myoglianin in regulating adult performance and lifespan by Augustin, Hrvoje, Adcott, Jennifer, Elliott, Christopher J. H., Partridge, Linda

“…Myoglianin, the Drosophila homolog of the secreted vertebrate proteins Myostatin and GDF-11, is an important regulator of neuronal modeling, and synapse…”
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Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease by Sofola, Oyinkan, Kerr, Fiona, Rogers, Iain, Killick, Richard, Augustin, Hrvoje, Gandy, Carina, Allen, Marcus J, Hardy, John, Lovestone, Simon, Partridge, Linda

“…Abeta peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the…”
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Invertebrate models of age-related muscle degeneration by Augustin, Hrvoje, Partridge, Linda

“…Functional and structural deterioration of muscles is an inevitable consequence of ageing in a wide variety of animal species. What underlies these changes is…”
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Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease by Sofola, Oyinkan, Kerr, Fiona, Rogers, Iain, Killick, Richard, Augustin, Hrvoje, Gandy, Carina, Allen, Marcus J, Hardy, John, Lovestone, Simon, Partridge, Linda

“…Aβ peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the…”
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Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster by Augustin, Hrvoje, McGourty, Kieran, Allen, Marcus J., Adcott, Jennifer, Wong, Chi Tung, Boucrot, Emmanuel, Partridge, Linda

“…The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor…”
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Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity by Gorsky, Marianna Karina, Burnouf, Sylvie, Sofola-Adesakin, Oyinkan, Dols, Jacqueline, Augustin, Hrvoje, Weigelt, Carina Marianne, Grönke, Sebastian, Partridge, Linda

“…Tau is a microtubule-associated protein that is highly soluble and natively unfolded. Its dysfunction is involved in the pathogenesis of several…”
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Deletion of endogenous Tau proteins is not detrimental in Drosophila by Burnouf, Sylvie, Grönke, Sebastian, Augustin, Hrvoje, Dols, Jacqueline, Gorsky, Marianna Karina, Werner, Jennifer, Kerr, Fiona, Alic, Nazif, Martinez, Pedro, Partridge, Linda

“…Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble…”
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Nonvesicular Release of Glutamate by Glial xCT Transporters Suppresses Glutamate Receptor Clustering In Vivo by Augustin, Hrvoje, Grosjean, Yael, Chen, Kaiyun, Sheng, Qi, Featherstone, David E

“…We hypothesized that cystine/glutamate transporters (xCTs) might be critical regulators of ambient extracellular glutamate levels in the nervous system and…”
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Medium-Chain Fatty Acids Rescue Motor Function and Neuromuscular Junction Degeneration in a IDrosophila/I Model of Amyotrophic Lateral Sclerosis by Dunn, Ella, Steinert, Joern R, Stone, Aelfwin, Sahota, Virender, Williams, Robin S. B, Snowden, Stuart, Augustin, Hrvoje

“…Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterised by progressive degeneration of the motor neurones. An expanded…”
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A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster by Augustin, Hrvoje, Zylbertal, Asaph, Partridge, Linda

“…The giant fiber system (GFS) is a multi-component neuronal pathway mediating rapid escape response in the adult fruit-fly , usually in the face of a…”
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The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology and Influences Locomotor Activity in Drosophila Larvae by Ziegler, Anna B., Augustin, Hrvoje, Clark, Nathan L., Berthelot-Grosjean, Martine, Simonnet, Mégane M., Steinert, Joern R., Geillon, Flore, Manière, Gérard, Featherstone, David E., Grosjean, Yael

“…Changes in synaptic physiology underlie neuronal network plasticity and behavioral phenomena, which are adjusted during development. The Drosophila larval…”
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Hemolymph Amino Acid Analysis of Individual Drosophila Larvae by Piyankarage, Sujeewa C, Augustin, Hrvoje, Grosjean, Yael, Featherstone, David E, Shippy, Scott A

“…One of the most widely used transgenic animal models in biology is Drosophila melanogaster, the fruit fly. Chemical information from this exceedingly small…”
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Electrophysiological recordings from the giant fiber pathway of D. melanogaster by Augustin, Hrvoje, Allen, Marcus J, Partridge, Linda

“…When startled adult D. melanogaster react by jumping into the air and flying away. In many invertebrate species, including D. melanogaster, the "escape" (or…”
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Electrophysiological Recordings from the Giant Fiber Pathway of D. melanogaster by Augustin, Hrvoje, Allen, Marcus J., Partridge, Linda

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