Search Results - "Augustin, Hellmut G."

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology by Augustin, Hellmut G., Koh, Gou Young

“…Blood vessels form one of the body's largest surfaces, serving as a critical interface between the circulation and the different organ environments. They…”
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Mechanisms of Vessel Pruning and Regression by Korn, Claudia, Augustin, Hellmut G.

“…The field of angiogenesis research has primarily focused on the mechanisms of sprouting angiogenesis. Yet vascular networks formed by vessel sprouting…”
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The role of the Angiopoietins in vascular morphogenesis by Thomas, Markus, Augustin, Hellmut G.

“…s The Angiopoietin/Tie system acts as a vascular specific ligand/receptor system to control endothelial cell survival and vascular maturation. The Angiopoietin…”
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Angiopoietin-2: An Attractive Target for Improved Antiangiogenic Tumor Therapy by GERALD, Damien, CHINTHARLAPALLI, Sudhakar, AUGUSTIN, Hellmut G, BENJAMIN, Laura E

“…Anti-VEGF pathway therapies primarily target immature blood vessels in tumors. However, emerging approaches to combine with targeted therapies impacting the…”
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Plastic roles of pericytes in the blood–retinal barrier by Park, Do Young, Lee, Junyeop, Kim, Jaeryung, Kim, Kangsan, Hong, Seonpyo, Han, Sangyeul, Kubota, Yoshiaki, Augustin, Hellmut G., Ding, Lei, Kim, Jin Woo, Kim, Hail, He, Yulong, Adams, Ralf H., Koh, Gou Young

“…The blood–retinal barrier (BRB) consists of tightly interconnected capillary endothelial cells covered with pericytes and glia, but the role of the pericytes…”
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Pericyte-expressed Tie2 controls angiogenesis and vessel maturation by Teichert, Martin, Milde, Laura, Holm, Annegret, Stanicek, Laura, Gengenbacher, Nicolas, Savant, Soniya, Ruckdeschel, Tina, Hasanov, Zulfiyya, Srivastava, Kshitij, Hu, Junhao, Hertel, Stella, Bartol, Arne, Schlereth, Katharina, Augustin, Hellmut G.

“…The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed…”
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Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment by Park, Jin-Sung, Kim, Il-Kug, Han, Sangyeul, Park, Intae, Kim, Chan, Bae, Jeomil, Oh, Seung Ja, Lee, Seungjoo, Kim, Jeong Hoon, Woo, Dong-Cheol, He, Yulong, Augustin, Hellmut G., Kim, Injune, Lee, Doheon, Koh, Gou Young

“…A destabilized tumor vasculature leads to limited drug delivery, hypoxia, detrimental tumor microenvironment, and even metastasis. We performed a side-by-side…”
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Angiodiversity and organotypic functions of sinusoidal endothelial cells by Koch, Philipp-Sebastian, Lee, Ki Hong, Goerdt, Sergij, Augustin, Hellmut G.

“…‘Angiodiversity’ refers to the structural and functional heterogeneity of endothelial cells (EC) along the segments of the vascular tree and especially within…”
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Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat by Hu, Junhao, Srivastava, Kshitij, Wieland, Matthias, Runge, Anja, Mogler, Carolin, Besemfelder, Eva, Terhardt, Dorothee, Vogel, Marion J., Cao, Liji, Korn, Claudia, Bartels, Susanne, Thomas, Markus, Augustin, Hellmut G.

“…Liver regeneration requires spatially and temporally precisely coordinated proliferation of the two major hepatic cell populations, hepatocytes and liver…”
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Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth by Srivastava, Kshitij, Hu, Junhao, Korn, Claudia, Savant, Soniya, Teichert, Martin, Kapel, Stephanie S., Jugold, Manfred, Besemfelder, Eva, Thomas, Markus, Pasparakis, Manolis, Augustin, Hellmut G.

“…Antiangiogenic tumor therapy has failed in the adjuvant setting. Here we show that inhibition of the Tie2 ligand angiopoietin-2 (Ang2) effectively blocks…”
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Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells by Cifarelli, Vincenza, Appak-Baskoy, Sila, Peche, Vivek S., Kluzak, Andrew, Shew, Trevor, Narendran, Ramkumar, Pietka, Kathryn M., Cella, Marina, Walls, Curtis W., Czepielewski, Rafael, Ivanov, Stoyan, Randolph, Gwendalyn J., Augustin, Hellmut G., Abumrad, Nada A.

“…Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but regulation of lymphatic vessel function and its link to disease…”
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A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver by Inverso, Donato, Shi, Jingjing, Lee, Ki Hong, Jakab, Moritz, Ben-Moshe, Shani, Kulkarni, Shubhada R., Schneider, Martin, Wang, Guanxiong, Komeili, Marziyeh, Vélez, Paula Argos, Riedel, Maria, Spegg, Carleen, Ruppert, Thomas, Schaeffer-Reiss, Christine, Helm, Dominic, Singh, Indrabahadur, Boutros, Michael, Chintharlapalli, Sudhakar, Heikenwalder, Mathias, Itzkovitz, Shalev, Augustin, Hellmut G.

“…Single-cell transcriptomics (scRNA-seq) has revolutionized the understanding of the spatial architecture of tissue structure and function. Advancing the…”
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STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis by Shen, Ying, Wang, Xiaohong, Liu, Yi, Singhal, Mahak, Gürkaşlar, Can, Valls, Aida Freire, Lei, Yi, Hu, Wenjie, Schermann, Géza, Adler, Heike, Yu, Fa-Xing, Fischer, Tamás, Zhu, Yi, Augustin, Hellmut G, Schmidt, Thomas, de Almodóvar, Carmen Ruiz

“…The nuclear translocation and activity of the cotranscriptional activators YAP and TAZ (YAP/TAZ) in endothelial cells (ECs) are crucial during developmental…”
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Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression by Korhonen, Emilia A, Murtomaki, Aino, Jha, Sawan Kumar, Anisimov, Andrey, Pink, Anne, Zhang, Yan, Stritt, Simon, Liaqat, Inam, Stanczuk, Lukas, Alderfer, Laura, Sun, Zhiliang, Kapiainen, Emmi, Singh, Abhishek, Sultan, Ibrahim, Lantta, Anni, Leppanen, Veli-Matti, Eklund, Lauri, He, Yulong, Augustin, Hellmut G, Vaahtomeri, Kari, Saharinen, Pipsa, Makinen, Taija, Alitalo, Kari

“…Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in…”
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Angiopoietin-2 is critical for cytokine-induced vascular leakage by Benest, Andrew V, Kruse, Karoline, Savant, Soniya, Thomas, Markus, Laib, Anna M, Loos, Elias K, Fiedler, Ulrike, Augustin, Hellmut G

“…Genetic experiments (loss-of-function and gain-of-function) have established the role of Angiopoietin/Tie ligand/receptor tyrosine kinase system as a regulator…”
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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling by Felcht, Moritz, Luck, Robert, Schering, Alexander, Seidel, Philipp, Srivastava, Kshitij, Hu, Junhao, Bartol, Arne, Kienast, Yvonne, Vettel, Christiane, Loos, Elias K, Kutschera, Simone, Bartels, Susanne, Appak, Sila, Besemfelder, Eva, Terhardt, Dorothee, Chavakis, Emmanouil, Wieland, Thomas, Klein, Christian, Thomas, Markus, Uemura, Akiyoshi, Goerdt, Sergij, Augustin, Hellmut G

“…Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine…”
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Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart by Jabs, Markus, Rose, Adam J, Lehmann, Lorenz H, Taylor, Jacqueline, Moll, Iris, Sijmonsma, Tjeerd P, Herberich, Stefanie E, Sauer, Sven W, Poschet, Gernot, Federico, Giuseppina, Mogler, Carolin, Weis, Eva-Maria, Augustin, Hellmut G, Yan, Minhong, Gretz, Norbert, Schmid, Roland M, Adams, Ralf H, Gröne, Hermann-Joseph, Hell, Rüdiger, Okun, Jürgen G, Backs, Johannes, Nawroth, Peter P, Herzig, Stephan, Fischer, Andreas

“…BACKGROUND:Nutrients are transported through endothelial cells before being metabolized in muscle cells. However, little is known about the regulation of…”
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Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling by Schreiber, Caroline, Saraswati, Supriya, Harkins, Shannon, Gruber, Annette, Cremers, Natascha, Thiele, Wilko, Rothley, Melanie, Plaumann, Diana, Korn, Claudia, Armant, Olivier, Augustin, Hellmut G, Sleeman, Jonathan P

“…ASAP1 is a multi-domain adaptor protein that regulates cytoskeletal dynamics, receptor recycling and intracellular vesicle trafficking. Its expression is…”
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Development of a novel immunocompetent murine tumor model for urothelial carcinoma using in vivo electroporation by Soleder, Stefan, Gengenbacher, Nicolas, Mogler, Carolin, Eckstein, Markus, Runge, Anja, Kriegmair, Maximilian C., Augustin, Hellmut G.

“…A lack of advanced preclinical mouse tumor models impedes the progress in urothelial carcinoma research. We present here a novel fast, robust, reliable, and…”
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Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice by Leibing, Thomas, Géraud, Cyrill, Augustin, Iris, Boutros, Michael, Augustin, Hellmut G., Okun, Jürgen G., Langhans, Claus‐Dieter, Zierow, Johanna, Wohlfeil, Sebastian A., Olsavszky, Victor, Schledzewski, Kai, Goerdt, Sergij, Koch, Philipp‐Sebastian

“…Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes…”
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