Search Results - "Augood, Sarah J."

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease by Guidetti, Paolo, Luthi-Carter, Ruth E., Augood, Sarah J., Schwarcz, Robert

“…Huntington's disease (HD), an inherited neurodegenerative disorder, is caused by an abnormal polyglutamine expansion in the huntingtin protein. This genetic…”
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TorsinA protein and neuropathology in early onset generalized dystonia with GAG deletion by Rostasy, Kevin, Augood, Sarah J, Hewett, Jeffrey W, Leung, Joanne Chung-on, Sasaki, Hikaru, Ozelius, Laurie J, Ramesh, Vijaya, Standaert, David G, Breakefield, Xandra O, Hedreen, John C

“…Familial, early onset, generalized torsion dystonia is the most common and severe primary dystonia. Most cases are caused by a 3-bp deletion (GAG) in the…”
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Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data by Jones, Lesley, Goldstein, Darlene R, Hughes, Gareth, Strand, Andrew D, Collin, Francois, Dunnett, Stephen B, Kooperberg, Charles, Aragaki, Aaron, Olson, James M, Augood, Sarah J, Faull, Richard L M, Luthi-Carter, Ruth, Moskvina, Valentina, Hodges, Angela K

“…Gene expression microarray experiments are expensive to conduct and guidelines for acceptable quality control at intermediate steps before and after the…”
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Regional and cellular gene expression changes in human Huntington's disease brain by Hodges, Angela, Strand, Andrew D., Aragaki, Aaron K., Kuhn, Alexandre, Sengstag, Thierry, Hughes, Gareth, Elliston, Lyn A., Hartog, Cathy, Goldstein, Darlene R., Thu, Doris, Hollingsworth, Zane R., Collin, Francois, Synek, Beth, Holmans, Peter A., Young, Anne B., Wexler, Nancy S., Delorenzi, Mauro, Kooperberg, Charles, Augood, Sarah J., Faull, Richard L.M., Olson, James M., Jones, Lesley, Luthi-Carter, Ruth

“…Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human…”
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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage by Kuhn, Alexandre, Goldstein, Darlene R., Hodges, Angela, Strand, Andrew D., Sengstag, Thierry, Kooperberg, Charles, Becanovic, Kristina, Pouladi, Mahmoud A., Sathasivam, Kirupa, Cha, Jang-Ho J., Hannan, Anthony J., Hayden, Michael R., Leavitt, Blair R., Dunnett, Stephen B., Ferrante, Robert J., Albin, Roger, Shelbourne, Peggy, Delorenzi, Mauro, Augood, Sarah J., Faull, Richard L.M., Olson, James M., Bates, Gillian P., Jones, Lesley, Luthi-Carter, Ruth

“…To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional…”
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Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain by Shelbourne, Peggy F., Keller-McGandy, Christine, Bi, Wenya Linda, Yoon, Song-Ro, Dubeau, Louis, Veitch, Nicola J., Vonsattel, Jean Paul, Wexler, Nancy S., Arnheim, Norman, Augood, Sarah J.

“…Huntington disease is caused by the expansion of a CAG repeat encoding an extended glutamine tract in a protein called huntingtin. Here, we provide evidence…”
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Expression and activity of antioxidants in the brain in progressive supranuclear palsy by Cantuti-Castelvetri, Ippolita, Keller-McGandy, Christine E, Albers, David S, Beal, M.Flint, Vonsattel, Jean-Paul, Standaert, David G, Augood, Sarah J

“…Recent evidence implicates oxidative stress in the pathophysiology of progressive supranuclear palsy (PSP). Thus, we undertook a study of the activity and…”
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Striatal interneurones: chemical, physiological and morphological characterization by Kawaguchi, Yasuo, Wilson, Charles J., Augood, Sarah J., Emson, Piers C.

“…The neostriatum is the largest component of the basal ganglia, and the main recipient of afferents to the basal ganglia from the cerebral cortex and thalamus…”
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Identification of nitric oxide synthase neurons for laser capture microdissection and mRNA quantification by Bi, Wenya Linda, Keller-McGandy, Christine, Standaert, David G, Augood, Sarah J

“…An immunohistochemical technique was developed to visualize nitric oxide synthase (NOS)-immunopositive neurons in fresh-frozen tissue sections of rat brain for…”
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Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1 by Zucker, Birgit, Luthi-Carter, Ruth, Kama, Jibrin A., Dunah, Anthone W., Stern, Edward A., Fox, Jonathan H., Standaert, David G., Young, Anne B., Augood, Sarah J.

“…Transcriptional dysregulation has been described as a central mechanism in the pathogenesis of Huntington's disease (HD), in which medium spiny projection…”
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New insights into progressive supranuclear palsy by Albers, David S, Augood, Sarah J

“…Increased oxidative damage and mitochondrial dysfunction have been suggested to play crucial roles in the pathogenesis of several neurodegenerative diseases,…”
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Distribution of the mRNAs encoding torsinA and torsinB in the normal adult human brain by Augood, Sarah J., Martin, Deborah M., Ozelius, Laurie J., Breakefield, Xandra O., Penney Jr, John B., Standaert, David G.

“…To gain insight into the neural pathways involved in the pathogenesis of DYT1 dystonia, we have mapped the cellular expression of the mRNA encoding torsinA and…”
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Distribution and ultrastructural localization of torsinA immunoreactivity in the human brain by Augood, Sarah J., Keller-McGandy, Christine E., Siriani, Ana, Hewett, Jeffrey, Ramesh, Vijaya, Sapp, Ellen, DiFiglia, Marion, Breakefield, Xandra O., Standaert, David G.

“…We have examined the distribution and ultrastructural localization of torsinA, the protein product of the TOR1A gene, in the normal adult human and Macaque…”
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Elevated levels of matrix metalloproteinases-9 and -1 and of tissue inhibitors of MMPs, TIMP-1 and TIMP-2 in postmortem brain tissue of progressive supranuclear palsy by Lorenzl, Stefan, Albers, David S., Chirichigno, Jason W., Augood, Sarah J., Beal, M.Flint

“…We determined the levels and tissue localization of matrix metalloproteinases (MMPs) as well as their endogenous tissue inhibitors (TIMPs) in postmortem brain…”
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Evidence for Oxidative Stress in the Subthalamic Nucleus in Progressive Supranuclear Palsy by Albers, David S., Augood, Sarah J., Martin, Deborach M., Standaert, David G., Vonsattel, Jean Paul G., Beal, M. Flint

“…: Increased free radical production and oxidative stress have been proposed as pathogenic mechanisms in several neurodegenerative disorders. Free radicals…”
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Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia by Ohnuma, Tohru, Augood, Sarah J, Arai, Heii, McKenna, Peter J, Emson, Piers C

“…A disturbance of glutamatergic transmission has been suggested to contribute to the development of schizophrenic pathophysiology based primarily on the ability…”
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Dopamine transmission in DYT1 dystonia by Augood, Sarah J, Hollingsworth, Z, Albers, David S, Yang, Lichuan, Leung, Joanne, Breakefield, Xandra O, Standaert, David G

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Molecular cloning and expression of rat torsinA in the normal and genetically dystonic (dt) rat by Ziefer, Philipp, Leung, Joanne, Razzano, Tara, Shalish, Christo, LeDoux, Mark S., Lorden, Joan F., Ozelius, Laurie, Breakefield, Xandra O., Standaert, David G., Augood, Sarah J.

“…Deletions within the TOR1A gene cause early-onset (DYT1) torsion dystonia. We have cloned and sequenced the rat cDNA homologue of TOR1A and found a 91%…”
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Expression of glutamic acid decarboxylase messenger RNA in rat medial preoptic area neurones during the oestrous cycle and after ovariectomy by Herbison, A E, Augood, S J, McGowan, E M

“…Evidence suggests that medial preoptic area (MPOA) neurones containing gamma-aminobutyric acid (GABA) are modulated directly by oestrogen. We have used an…”
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Expression of α-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's disease by Solano, Steven M., Miller, David W., Augood, Sarah J., Young, Anne B., Penney Jr, John B.

“…Mutations in the α‐synuclein, parkin, and ubiquitin carboxy‐terminal hydrolase L1 (UCH‐L1) genes have been linked to some cases of familial Parkinson's…”
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