Search Results - "Auger, Jocelyn"

Platelet response heterogeneity in thrombus formation by Munnix, Imke C A, Cosemans, Judith M E M, Auger, Jocelyn M, Heemskerk, Johan W M

“…Vascular injury leads to formation of a structured thrombus as a consequence of platelet activation and aggregation, thrombin and fibrin formation, and…”
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Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear by Berny, Michelle A, Munnix, Imke C A, Auger, Jocelyn M, Schols, Saskia E M, Cosemans, Judith M E M, Panizzi, Peter, Bock, Paul E, Watson, Steve P, McCarty, Owen J T, Heemskerk, Johan W M

“…The generation of thrombin is a critical process in the formation of venous thrombi. In isolated plasma under static conditions, phosphatidylserine…”
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Dual role of collagen in factor XII–dependent thrombus formation by van der Meijden, Paola E.J., Munnix, Imke C.A., Auger, Jocelyn M., Govers-Riemslag, José W.P., Cosemans, Judith M. E.M., Kuijpers, Marijke J.E., Spronk, Henri M., Watson, Steve P., Renné, Thomas, Heemskerk, Johan W.M.

“…In vivo mouse models have indicated that the intrinsic coagulation pathway, initiated by factor XII, contributes to thrombus formation in response to major…”
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The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis by Senis, Yotis A., Tomlinson, Michael G., Ellison, Stuart, Mazharian, Alexandra, Lim, Jenson, Zhao, Yan, Kornerup, Kristin N., Auger, Jocelyn M., Thomas, Steve G., Dhanjal, Tarvinder, Kalia, Neena, Zhu, Jing W., Weiss, Arthur, Watson, Steve P.

“…Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including…”
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Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow by McCarty, Owen J.T., Larson, Mark K., Auger, Jocelyn M., Kalia, Neena, Atkinson, Ben T., Pearce, Andrew C., Ruf, Sandra, Henderson, Robert B., Tybulewicz, Victor L.J., Machesky, Laura M., Watson, Steve P.

“…The role of Rac family proteins in platelet spreading on matrix proteins under static and flow conditions has been investigated by using Rac-deficient…”
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Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets by Pears, Catherine J., Thornber, Kelly, Auger, Jocelyn M., Hughes, Craig E., Grygielska, Beata, Protty, Majd B., Pearce, Andrew C., Watson, Steve P.

“…Background Increasing evidence suggests that individual isoforms of protein kinase C (PKC) play distinct roles in regulating platelet activation…”
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Adhesion of human and mouse platelets to collagen under shear: a unifying model by Auger, Jocelyn M, Kuijpers, Marijke J. E, Senis, Yotis A, Watson, Steve P, Heemskerk, Johan W. M

“…ABSTRACT There is presently confusion as to the roles of α2β1 and GPVI in supporting platelet adhesion and aggregate formation on collagen at intermediate/high…”
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The Glycoprotein VI-Phospholipase Cγ2 Signaling Pathway Controls Thrombus Formation Induced by Collagen and Tissue Factor In Vitro and In Vivo by Munnix, Imke C.A, Strehl, Amrei, Kuijpers, Marijke J.E, Auger, Jocelyn M, van der Meijden, Paola E.J, van Zandvoort, Marc A.M, oude Egbrink, Mirjam G.A, Nieswandt, Bernhard, Heemskerk, Johan W.M

“…OBJECTIVE—Both collagen and tissue factor can be initiating factors in thrombus formation. We investigated the signaling pathway of collagen-induced platelet…”
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Critical Role of FcR γ-Chain, LAT, PLCγ2 and Thrombin in Arteriolar Thrombus Formation upon Mild, Laser-Induced Endothelial Injury In Vivo by Kalia, Neena, Auger, Jocelyn M., Atkinson, Ben, Watson, Steve P.

“…Objective: The role of collagen receptor complex GPVI-FcR γ-chain, PLCγ2 and LAT in laser-induced thrombosis is unclear. Controversy surrounds whether collagen…”
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Dynamic Tyrosine Kinase-Regulated Signaling and Actin Polymerisation Mediate Aggregate Stability Under Shear by Auger, Jocelyn M, Watson, Steve P

“…OBJECTIVE—Aggregate formation on collagen at arteriolar rates of shear is mediated by coordinated signaling between tyrosine kinase–linked and G…”
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GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase by Marshall, Stuart J., Senis, Yotis A., Auger, Jocelyn M., Feil, Robert, Hofmann, Franz, Salmon, Gary, Peterson, J. Thomas, Burslem, Frank, Watson, Steve P.

“…Glycoprotein Ib-IX-V (GPIb-IX-V) mediates platelet tethering to von Willebrand factor (VWF), recruiting platelets into the thrombus, and activates integrin…”
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Minimal regulation of platelet activity by PECAM-1 by Dhanjal, Tarvinder S., Ross, Ewan A., Auger, Jocelyn M., Mccarty, Owen J. T., Hughes, Craig E., Senis, Yotis A., Watson, Steve P.

“…PECAM-1 is a member of the superfamily of immunoglobulins (Ig) and is expressed on platelets at moderate level. PECAM-1 has been reported to have contrasting…”
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Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites by Suzuki-Inoue, Katsue, Wilde, Jonathan I, Andrews, Robert K, Auger, Jocelyn M, Siraganian, Reuben P, Sekiya, Fujio, Rhee, Sue Goo, Watson, Steve P

“…Glycoproteins GPVI and GPIb-IX-V stimulate robust tyrosine phosphorylation of Syk and PLCg2 (phospholipase Cg2) in washed platelets, but only the former…”
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Studies on the actin-binding protein HS1 in platelets by Thomas, Steven G, Calaminus, Simon D J, Auger, Jocelyn M, Watson, Stephen P, Machesky, Laura M

“…The platelet cytoskeleton mediates the dramatic change in platelet morphology that takes place upon activation and stabilizes thrombus formation. The Arp2/3…”
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Segregation of Platelet Aggregatory and Procoagulant Microdomains in Thrombus Formation: Regulation by Transient Integrin Activation by Munnix, Imke C.A, Kuijpers, Marijke J.E, Auger, Jocelyn, Thomassen, Christella M.L.G.D, Panizzi, Peter, van Zandvoort, Marc A.M, Rosing, Jan, Bock, Paul E, Watson, Steve P, Heemskerk, Johan W.M

“…OBJECTIVE—Platelets play a dual role in thrombosis by forming aggregates and stimulating coagulation. We investigated the commitment of platelets to these…”
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Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets by Pears, Catherine J, Thornber, Kelly, Auger, Jocelyn M, Hughes, Craig E, Grygielska, Beata, Protty, Majd B, Pearce, Andrew C, Watson, Steve P

“…Increasing evidence suggests that individual isoforms of protein kinase C (PKC) play distinct roles in regulating platelet activation. In this study, we focus…”
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Physiological Levels of Jak2 V617F Result in Enhanced Megakaryocyte Differentiation, Proplatelet Formation and Platelet Reactivity by Ghevaert, Cedric J, Li, Juan, Severin, Sonia, Auger, Jocelyn, Watson, Steve, Green, Anthony R.

“…Abstract 226 The major clinical challenge in treating patients with myeloproliferative diseases (MPD) such as essential thrombocythaemia (ET) and polycythaemia…”
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Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo by Kalia, Neena, Auger, Jocelyn M, Atkinson, Ben, Watson, Steve P

“…The role of collagen receptor complex GPVI-FcR gamma-chain, PLCgamma2 and LAT in laser-induced thrombosis is unclear. Controversy surrounds whether collagen is…”
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Spatial Distribution of Factor Xa, Thrombin, and Fibrin by Berny, Michelle A, Munnix, Imke C. A, Auger, Jocelyn M, Schols, Saskia E. M, Cosemans, Judith M. E. M, Panizzi, Peter, Bock, Paul E, Watson, Steve P, McCarty, Owen J. T, Heemskerk, Johan W. M

“…Background The generation of thrombin is a critical process in the formation of venous thrombi. In isolated plasma under static conditions, phosphatidylserine…”
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Differential Roles of the PKC Novel Isoforms, PKC[delta] and PKC[epsilon], in Mouse and Human Platelets by Pears, Catherine J, Thornber, Kelly, Auger, Jocelyn M, Hughes, Craig E, Grygielska, Beata, Protty, Majd B, Pearce, Andrew C, Watson, Steve P

“…Background Increasing evidence suggests that individual isoforms of protein kinase C (PKC) play distinct roles in regulating platelet activation…”
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