Search Results - "Augenlicht, Leonard H"

Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges by Choi, Jiahn, Augenlicht, Leonard H.

“…The intestinal epithelium is the first line of defense and acts as an interface between the vast microbial world within the gastrointestinal tract and the…”
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Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals by Shan, Meimei, Gentile, Maurizio, Yeiser, John R., Walland, A. Cooper, Bornstein, Victor U., Chen, Kang, He, Bing, Cassis, Linda, Bigas, Anna, Cois, Montserrat, Comerma, Laura, Huang, Bihui, Blander, Magarian, Xiong, Huabao, Mayer, Lloyd, Berin, Cecilia, Augenlicht, Leonard H., Velcich, Anna, Cerutti, Andrea

“…A dense mucus layer in the large intestine prevents inflammation by shielding the underlying epithelium from luminal bacteria and food antigens. This mucus…”
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EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1 by Nauman, Mohd, Varshney, Shweta, Choi, Jiahn, Augenlicht, Leonard H., Stanley, Pamela

“…Notch signaling determines cell fates in mouse intestine. Notch receptors contain multiple epidermal growth factor-like (EGF) repeats modified by O-glycans…”
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Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer by Wilson, Andrew J., Byun, Do-Sun, Popova, Natalia, Murray, Lucas B., L'Italien, Kaitlin, Sowa, Yoshihiro, Arango, Diego, Velcich, Anna, Augenlicht, Leonard H., Mariadason, John M.

“…Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and apoptosis of colon cancer cell lines in vitro and have demonstrated…”
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PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab by JHAWER, Minaxi, GOEL, Sanjay, AUGENLICHT, Leonard H, PEREZ SOLER, Roman, MARIADASON, John M, WILSON, Andrew J, MONTAGNA, Cristina, LING, Yi-He, BYUN, Do-Sun, NASSER, Shannon, ARANGO, Diego, SHIN, Joongho, KLAMPFER, Lidija

“…Cetuximab is a monoclonal antibody that targets the human epidermal growth factor receptor (EGFR). Although approved for use in EGFR-overexpressing advanced…”
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Transition state analogue of MTAP extends lifespan of APCMin/+ mice by Firestone, Ross S., Feng, Mu, Basu, Indranil, Peregrina, Karina, Augenlicht, Leonard H., Schramm, Vern L.

“…A mouse model of human Familial Adenomatous Polyposis responds favorably to pharmacological inhibition of 5′-methylthioadenosine phosphorylase (MTAP)…”
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MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells by Papetti, Michael, Augenlicht, Leonard H.

“…Multiple signals, controlling both proliferation and differentiation, must be integrated in the reprogramming of intestinal epithelial cells during maturation…”
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Mybl2, downregulated during colon epithelial cell maturation, is suppressed by miR-365 by Papetti, Michael, Augenlicht, Leonard H

“…Altered profiles of gene expression reflect the reprogramming of intestinal epithelial cells during their maturation along the crypt-luminal axis. To focus on…”
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The Intestinal Epithelial Cell Differentiation Marker Intestinal Alkaline Phosphatase (ALPi) Is Selectively Induced by Histone Deacetylase Inhibitors (HDACi) in Colon Cancer Cells in a Kruppel-like Factor 5 (KLF5)-dependent Manner by Shin, Joongho, Carr, Azadeh, Corner, Georgia A., Tögel, Lars, Dávaos-Salas, Mercedes, Tran, Hoanh, Chueh, Anderly C., Al-Obaidi, Sheren, Chionh, Fiona, Ahmed, Naseem, Buchanan, Daniel D., Young, Joanne P., Malo, Madhu S., Hodin, Richard A., Arango, Diego, Sieber, Oliver M., Augenlicht, Leonard H., Dhillon, Amardeep S., Weber, Thomas K., Mariadason, John M.

“…The histone deacetylase inhibitor (HDACi) sodium butyrate promotes differentiation of colon cancer cells as evidenced by induced expression and enzyme activity…”
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Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer by Wang, Donghai, Peregrina, Karina, Dhima, Elena, Lin, Elaine Y, Mariadason, John M, Augenlicht, Leonard H

“…Nutritional and genetic risk factors for intestinal tumors are additive on mouse tumor phenotype, establishing that diet and genetic factors impact risk by…”
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Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction by WILSON, Andrew J, CHUEH, Anderly C, SMARTT, Helena J. M, MURRAY, Lucas B, NICHOLAS, Courtney, HEERDT, Barbara G, ARANGO, Diego, AUGENLICHT, Leonard H, MARIADASON, John M, TÖGEL, Lars, CORNER, Georgia A, AHMED, Naseem, GOEL, Sanjay, BYUN, Do-Sun, NASSER, Shannon, HOUSTON, Michele A, JHAWER, Minaxi

“…Histone deacetylase inhibitors (HDACi) induce growth arrest and apoptosis in colon cancer cells and are being considered for colon cancer therapy. The…”
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The effect of lung cancer on cytokine expression in peripheral blood mononuclear cells by Chang, David H, Rutledge, John R, Patel, Ankur A, Heerdt, Barbara G, Augenlicht, Leonard H, Korst, Robert J

“…The purpose of this study is to evaluate cytokine expression by peripheral blood mononuclear cells (PBMC) from stage I lung cancer patients and to confirm…”
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Dietary cholecalciferol and calcium levels in a Western-style defined rodent diet alter energy metabolism and inflammatory responses in mice by Bastie, Claire C, Gaffney-Stomberg, Erin, Lee, Ting-Wen A, Dhima, Elena, Pessin, Jeffrey E, Augenlicht, Leonard H

“…Male and female C57Bl6 mice were fed a control AIN76A diet, a new Western-style diet (NWD1) reflecting dietary patterns linked to elevated colon cancer…”
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c-Jun NH2 -Terminal Kinase 1 Plays a Critical Role in Intestinal Homeostasis and Tumor Suppression by Tong, Chang, Yin, Zhinan, Song, Zibo, Dockendorff, Ashley, Huang, Chuanshu, Mariadason, John, Flavell, Richard A, Davis, Roger J, Augenlicht, Leonard H, Yang, Wancai

“…The c-Jun NH2 -terminal kinase (JNK) signal transduction pathway plays important roles in cellular processes and stress. However, the role of JNK1 in…”
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Intestinal Deletion of Pofut1 in the Mouse Inactivates Notch Signaling and Causes Enterocolitis by Guilmeau, Sandra, Flandez, Marta, Bancroft, Laura, Sellers, Rani S, Tear, Benjamin, Stanley, Pamela, Augenlicht, Leonard H

“…Background & Aims: Notch downstream targets are fundamental to intestinal cell lineage commitment and are suggested as therapeutic targets for colon cancer…”
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Kaiso-Deficient Mice Show Resistance to Intestinal Cancer by Prokhortchouk, Anna, Sansom, Owen, Selfridge, Jim, Caballero, Isabel M., Salozhin, Sergey, Aithozhina, Dana, Cerchietti, Leandro, Meng, Fan Guo, Augenlicht, Leonard H., Mariadason, John M., Hendrich, Brian, Melnick, Ari, Prokhortchouk, Egor, Clarke, Alan, Bird, Adrian

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression by HEERDT, Barbara G, HOUSTON, Michele A, AUGENLICHT, Leonard H

“…We subcloned cell lines from SW620 cells establishing that, despite the dynamic nature of the mitochondrial membrane potential (Deltapsim), there are…”
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Na⁺/Monocarboxylate Transport (SMCT) Protein Expression Correlates with Survival in Colon Cancer: Molecular Characterization of SMCT by Paroder, Viktoriya, Spencer, Shelly R., Paroder, Monika, Arango, Diego, Schwartz, Simo, Mariadason, John M., Augenlicht, Leonard H., Eskandari, Sepehr, Carrasco, Nancy

“…We report an extensive characterization of the Na⁺/monocarboxylate transporter (SMCT), a plasma membrane protein that mediates active transport of…”
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Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis by Mariadason, John M., Nicholas, Courtney, L’Italien, Kaitlin E., Zhuang, Min, Smartt, Helena J.M., Heerdt, Barbara G., Yang, Wancai, Corner, Georgia A., Wilson, Andrew J., Klampfer, Lidija, Arango, Diego, Augenlicht, Leonard H.

“…Background & Aims: To define the genetic reprogramming that drives intestinal epithelial cell maturation along the crypt-villus axis, enterocytes were…”
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Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy by Khabele, Dineo, Son, Deok-Soo, Parl, Angelika K., Goldberg, Gary L., Augenlicht, Leonard H., Mariadason, John M., Montgomery Rice, Valerie

“…Abstract There is an urgent need to develop new strategies to treat ovarian cancer, the most deadly gynecologic malignancy. Histone deacetylase (HDAC)…”
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