Search Results - "Augello, A."

SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling by Blattner, Mirjam, Liu, Deli, Robinson, Brian D., Huang, Dennis, Poliakov, Anton, Gao, Dong, Nataraj, Srilakshmi, Deonarine, Lesa D., Augello, Michael A., Sailer, Verena, Ponnala, Lalit, Ittmann, Michael, Chinnaiyan, Arul M., Sboner, Andrea, Chen, Yu, Rubin, Mark A., Barbieri, Christopher E.

“…Recurrent point mutations in SPOP define a distinct molecular subclass of prostate cancer. Here, we describe a mouse model showing that mutant SPOP drives…”
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CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis by Augello, Michael A., Liu, Deli, Deonarine, Lesa D., Robinson, Brian D., Huang, Dennis, Stelloo, Suzan, Blattner, Mirjam, Doane, Ashley S., Wong, Elissa W.P., Chen, Yu, Rubin, Mark A., Beltran, Himisha, Elemento, Olivier, Bergman, Andries M., Zwart, Wilbert, Sboner, Andrea, Dephoure, Noah, Barbieri, Christopher E.

“…Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common alterations in prostate cancer (PCa); however, the tumor-suppressive…”
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MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer by de Leeuw, Renée, McNair, Christopher, Schiewer, Matthew J, Neupane, Neermala Poudel, Brand, Lucas J, Augello, Michael A, Li, Zhen, Cheng, Larry C, Yoshida, Akihiro, Courtney, Sean M, Hazard, E Starr, Hardiman, Gary, Hussain, Maha H, Diehl, J Alan, Drake, Justin M, Kelly, Wm Kevin, Knudsen, Karen E

“…Loss of cell-cycle control is a hallmark of cancer, which can be targeted with agents, including cyclin-dependent kinase-4/6 (CDK4/6) kinase inhibitors that…”
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Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches by Augello, Andrea, Kurth, Tobias B, De Bari, Cosimo

“…Mesenchymal Stromal Progenitor/Stem Cells (MSCs) are a rare population of non-hematopoietic stromal cells, present in the bone marrow and most connective…”
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Dual roles of PARP-1 promote cancer growth and progression by Schiewer, Matthew J, Goodwin, Jonathan F, Han, Sumin, Brenner, J Chad, Augello, Michael A, Dean, Jeffry L, Liu, Fengzhi, Planck, Jamie L, Ravindranathan, Preethi, Chinnaiyan, Arul M, McCue, Peter, Gomella, Leonard G, Raj, Ganesh V, Dicker, Adam P, Brody, Jonathan R, Pascal, John M, Centenera, Margaret M, Butler, Lisa M, Tilley, Wayne D, Feng, Felix Y, Knudsen, Karen E

“…PARP-1 is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation. PARP-1 has well-described functions in DNA damage repair and also…”
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Targeting cell cycle and hormone receptor pathways in cancer by Comstock, C E S, Augello, M A, Goodwin, J F, de Leeuw, R, Schiewer, M J, Ostrander, W F, Burkhart, R A, McClendon, A K, McCue, P A, Trabulsi, E J, Lallas, C D, Gomella, L G, Centenera, M M, Brody, J R, Butler, L M, Tilley, W D, Knudsen, K E

“…The cyclin/cyclin-dependent kinase (CDK)/retinoblastoma (RB)-axis is a critical modulator of cell cycle entry and is aberrant in many human cancers. New nodes…”
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Multifunctional scaffolds for biomedical applications: Crafting versatile solutions with polycaprolactone enriched by graphene oxide by Friggeri, G., Moretti, I., Amato, F., Marrani, A. G., Sciandra, F., Colombarolli, S. G., Vitali, A., Viscuso, S., Augello, A., Cui, L., Perini, G., De Spirito, M., Papi, M., Palmieri, V.

“…The pressing need for multifunctional materials in medical settings encompasses a wide array of scenarios, necessitating specific tissue functionalities. A…”
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Cell cycle-coupled expansion of AR activity promotes cancer progression by McNair, C, Urbanucci, A, Comstock, C E S, Augello, M A, Goodwin, J F, Launchbury, R, Zhao, S G, Schiewer, M J, Ertel, A, Karnes, J, Davicioni, E, Wang, L, Wang, Q, Mills, I G, Feng, F Y, Li, W, Carroll, J S, Knudsen, K E

“…The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic…”
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Identification of ASF/SF2 as a Critical, Allele-Specific Effector of the Cyclin D1b Oncogene by OLSHAVSKI, Nicholas A, COMSTOCK, Clay E. S, CHIEWE, Matthew J. S, AUGELLO, Michael A, HYSIOP, Terry, SETTE, Claudio, JINSONG ZHANG, PARYSEK, Linda M, KNUDSEN, Karen E

“…The cyclin D1b oncogene arises from alternative splicing of the CCND1 transcript, and harbors markedly enhanced oncogenic functions not shared by full-length…”
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Cyclin D1 Splice Variants: Polymorphism, Risk, and Isoform-Specific Regulation in Prostate Cancer by COMSTOCK, Clay E. S, AUGELLO, Michael A, HOANG, Hoa N, GILES, Graham G, SEVERI, Gianluca, HAYES, Vanessa M, HENDERSON, Brian E, LE MARCHAND, Loic, KOLONEL, Laurence N, HAIMAN, Christopher A, BAFFA, Raifaele, GOMELLA, Leonard G, PE BENITO, Ruth, KNUDSEN, Erik S, RUI, Hallgeir, HENSHALL, Susan M, SUTHERLAND, Robert L, KNUDSEN, Karen E, KARCH, Jason, TRAN, Thai H, UTAMA, Fransiscus E, TINDALL, Elizabeth A, YING WANG, BURD, Craig J, GROH, Eric M

“…Purpose: Alternative CCND1 splicing results in cyclin D1b, which has specialized, protumorigenic functions in prostate not shared by the cyclin D1a (full…”
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mTOR is a selective effector of the radiation therapy response in androgen receptor-positive prostate cancer by Schiewer, Matthew J, Den, Robert, Hoang, David T, Augello, Michael A, Lawrence, Yaacov R, Dicker, Adam P, Knudsen, Karen E

“…Ionizing radiation (IR) is used frequently in the management of multiple tumor types, including both organ-confined and locally advanced prostate cancer (PCa)…”
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Consequence of the tumor‐associated conversion to cyclin D1b by Augello, Michael A, Berman‐Booty, Lisa D, Carr, Richard, Yoshida, Akihiro, Dean, Jeffry L, Schiewer, Matthew J, Feng, Felix Y, Tomlins, Scott A, Gao, Erhe, Koch, Walter J, Benovic, Jeffrey L, Diehl, John Alan, Knudsen, Karen E

“…Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular…”
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Yes-associated protein regulates proliferation and chondrogenic differentiation of mesenchymal stem cells by Roelofs, A.J, Karystinou, A, Augello, A, Neve, A, Cantatore, F.P, Wackerhage, H, De Bari, C

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N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer by Berger, Adeline, Brady, Nicholas J, Bareja, Rohan, Robinson, Brian, Conteduca, Vincenza, Augello, Michael A, Puca, Loredana, Ahmed, Adnan, Dardenne, Etienne, Lu, Xiaodong, Hwang, Inah, Bagadion, Alyssa M, Sboner, Andrea, Elemento, Olivier, Paik, Jihye, Yu, Jindan, Barbieri, Christopher E, Dephoure, Noah, Beltran, Himisha, Rickman, David S

“…Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration resistant prostate cancers become…”
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FOXA1: master of steroid receptor function in cancer by Augello, Michael A, Hickey, Theresa E, Knudsen, Karen E

“…FOXA transcription factors are potent, context‐specific mediators of development that hold specialized functions in hormone‐dependent tissues. Over the last…”
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Identifying synergistic high-order 3D chromatin conformations from genome-scale nanopore concatemer sequencing by Deshpande, Aditya S., Ulahannan, Netha, Pendleton, Matthew, Dai, Xiaoguang, Ly, Lynn, Behr, Julie M., Schwenk, Stefan, Liao, Will, Augello, Michael A., Tyer, Carly, Rughani, Priyesh, Kudman, Sarah, Tian, Huasong, Otis, Hannah G., Adney, Emily, Wilkes, David, Mosquera, Juan Miguel, Barbieri, Christopher E., Melnick, Ari, Stoddart, David, Turner, Daniel J., Juul, Sissel, Harrington, Eoghan, Imieliński, Marcin

“…High-order three-dimensional (3D) interactions between more than two genomic loci are common in human chromatin, but their role in gene regulation is unclear…”
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AR function in promoting metastatic prostate cancer by Augello, Michael A., Den, Robert B., Knudsen, Karen E.

“…Prostate cancer (PCa) remains a leading cause of cancer-related death in the USA. While localized lesions are effectively treated through radical prostatectomy…”
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Tumor subtype defines distinct pathways of molecular and clinical progression in primary prostate cancer by Liu, Deli, Augello, Michael A, Grbesa, Ivana, Prandi, Davide, Liu, Yang, Shoag, Jonathan E, Karnes, R Jeffrey, Trock, Bruce J, Klein, Eric A, Den, Robert B, Demichelis, Francesca, Davicioni, Elai, Sboner, Andrea, Barbieri, Christopher E

“…BACKGROUNDMolecular characterization of prostate cancer (PCa) has revealed distinct subclasses based on underlying genomic alterations occurring early in the…”
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Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity by Grbesa, Ivana, Augello, Michael A., Liu, Deli, McNally, Dylan R., Gaffney, Christopher D., Huang, Dennis, Lin, Kevin, Ivenitsky, Daria, Goueli, Ramy, Robinson, Brian D., Khani, Francesca, Deonarine, Lesa D., Blattner, Mirjam, Elemento, Olivier, Davicioni, Elai, Sboner, Andrea, Barbieri, Christopher E.

“…The normal androgen receptor (AR) cistrome and transcriptional program are fundamentally altered in prostate cancer (PCa). Here, we profile the chromatin…”
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Genetic algorithm for the identification of the equivalent interconnected European power grid by Tina, G. M., Nicolosi, C. F., Augello, A., Stefanelli, D.

“…Currently, European national power systems are facing operational challenges due to an increasingly intermittent supply of electricity given by the growing…”
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