Comparative ultrastructure of fibrin networks of a dog after thrombotic ischaemic stroke

A cerebrovascular accident or stroke is a rare condition in dogs, but previous studies suggest that it is now increasingly being recognised. Platelets and fibrin networks are involved in haemostasis,which is disrupted during a thrombotic event. In this study we investigate the ultrastructure of the...

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Bibliographic Details
Published in:	Onderstepoort journal of veterinary research Vol. 77; no. 1; pp. E1 - E4
Main Authors:	Pretorius, Etheresia, Windberger, Ursula B, Oberholzer, Hester M, Auer, Roland E
Format:	Journal Article
Language:	English
Published:	South Africa ARC-Onderstepoort Veterinary Institute - Agricultural Research Council 01-01-2010 AOSIS
Subjects:	Agriculture, Dairy & Animal Science Anatomy & Morphology Animals Biochemistry & Molecular Biology Case-Control Studies dog Dog Diseases - blood Dog Diseases - drug therapy Dogs Female Fibrin - ultrastructure fibrin networks Fibrinolytic Agents - therapeutic use Hemostasis Ischemic stroke Microscopy, Electron, Scanning - veterinary Pharmacology & Pharmacy Physiology platelets Scanning Electron Microscopy Streptokinase - therapeutic use Stroke - blood Stroke - drug therapy Stroke - veterinary Veterinary Sciences Ischemic stroke Scanning Electron Microscopy dog fibrin networks platelets
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Summary:	A cerebrovascular accident or stroke is a rare condition in dogs, but previous studies suggest that it is now increasingly being recognised. Platelets and fibrin networks are involved in haemostasis,which is disrupted during a thrombotic event. In this study we investigate the ultrastructure of the fibrin networks of a dog that had suffered ischaemic stroke, following suspected thromboembolism from clots that became dislodged during catheter maintenance (flushing with heparinised saline) 2 days after carotid artery catheter insertion. Fibrin networks of blood samples that were collected immediately after the stroke, 15 min after treatment with streptokinase and 24 h after treatment, were studied. The results were compared to those of two control dogs. During a stroke, fibrin morphology changes to form a thick, matted layer.Post-treatment ultrastructure shows that the fibrin morphology returns to that comparable to controls. Our results show that during thrombotic risk, fibrin network morphology changes visibly and reduces the fibrinolytic activity of the coagulation system.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0030-2465 2219-0635 2219-0635
DOI:	10.4102/ojvr.v77i1.4