Search Results - "Auer, Rebecca C."

Killers 2.0: NK cell therapies at the forefront of cancer control by Hodgins, Jonathan J, Khan, Sarwat T, Park, Maria M, Auer, Rebecca C, Ardolino, Michele

“…Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and elimination of cancer. As we have learned more and more about the…”
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Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies by Market, Marisa, Angka, Leonard, Martel, Andre B, Bastin, Donald, Olanubi, Oladunni, Tennakoon, Gayashan, Boucher, Dominique M, Ng, Juliana, Ardolino, Michele, Auer, Rebecca C

“…Natural Killer (NK) cells are innate immune responders critical for viral clearance and immunomodulation. Despite their vital role in viral infection, the…”
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Postoperative Natural Killer Cell Dysfunction: The Prime Suspect in the Case of Metastasis Following Curative Cancer Surgery by Market, Marisa, Tennakoon, Gayashan, Auer, Rebecca C

“…Surgical resection is the foundation for the curative treatment of solid tumors. However, metastatic recurrence due to the difficulty in eradicating…”
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Dysfunctional Natural Killer Cells in the Aftermath of Cancer Surgery by Angka, Leonard, Khan, Sarwat T, Kilgour, Marisa K, Xu, Rebecca, Kennedy, Michael A, Auer, Rebecca C

“…The physiological changes that occur immediately following cancer surgeries initiate a chain of events that ultimately result in a short pro-, followed by a…”
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Safety and efficacy of autologous cell vaccines in solid tumors: a systematic review and meta-analysis of randomized control trials by Bastin, Donald J., Montroy, Joshua, Kennedy, Michael A., Martel, Andre B., Shorr, Risa, Ghiasi, Maryam, Boucher, Dominique M., Wong, Boaz, Gresham, Louise, Diallo, Jean-Simon, Fergusson, Dean A., Lalu, Manoj M., Kekre, Natasha, Auer, Rebecca C.

“…We conducted a systematic review and meta-analysis of randomized control trials to formally assess the safety and efficacy of autologous whole cell vaccines as…”
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Phosphodiesterase-5 inhibition reduces postoperative metastatic disease by targeting surgery-induced myeloid derived suppressor cell-dependent inhibition of Natural Killer cell cytotoxicity by Tai, Lee-Hwa, Alkayyal, Almohanad A., Leslie, Amanda L., Sahi, Shalini, Bennett, Sean, Tanese de Souza, Christiano, Baxter, Katherine, Angka, Leonard, Xu, Rebecca, Kennedy, Michael A., Auer, Rebecca C.

“…Cancer surgery while necessary for primary tumor removal, has been shown to induce immune suppression and promote metastases in preclinical models and human…”
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Association between perioperative beta blocker use and cancer survival following surgical resection by Musselman, Reilly P., Bennett, Sean, Li, Wenbin, Mamdani, Muhammad, Gomes, Tara, van Walraven, Carl, Boushey, Robin, Al-Obeed, Omar, Al-Omran, Mohammed, Auer, Rebecca C.

“…Recent studies have demonstrated an association between beta-blocker exposure and improved survival in multiple cancer types. We sought to investigate the…”
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Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence by Ananth, Abhirami A, Tai, Lee-Hwa, Lansdell, Casey, Alkayyal, Almohanad A, Baxter, Katherine E, Angka, Leonard, Zhang, Jiqing, Tanese de Souza, Christiano, Stephenson, Kyle B, Parato, Kelley, Bramson, Jonathan L, Bell, John C, Lichty, Brian D, Auer, Rebecca C

“…Anti-tumor CD8+ T cells are a key determinant for overall survival in patients following surgical resection for solid malignancies. Using a mouse model of…”
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Predictors of a true complete response among disappearing liver metastases from colorectal cancer after chemotherapy by Auer, Rebecca C., White, Rebekah R., Kemeny, Nancy E., Schwartz, Lawrence H., Shia, Jinru, Blumgart, Leslie H., DeMatteo, Ronald P., Fong, Yuman, Jarnagin, William R., D'Angelica, Michael I.

“…BACKGROUND: During chemotherapy, some colorectal liver metastases (LMs) disappear on serial imaging. This disappearance may represent a complete response (CR)…”
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Vanadyl sulfate-enhanced oncolytic virus immunotherapy mediates the antitumor immune response by upregulating the secretion of pro-inflammatory cytokines and chemokines by Alluqmani, Nouf, Jirovec, Anna, Taha, Zaid, Varette, Oliver, Chen, Andrew, Serrano, Daniel, Maznyi, Glib, Khan, Sarwat, Forbes, Nicole E, Arulanandam, Rozanne, Auer, Rebecca C, Diallo, Jean-Simon

“…Oncolytic viruses (OVs) are promising anticancer treatments that specifically replicate in and kill cancer cells and have profound immunostimulatory…”
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Preventing Surgery-Induced NK Cell Dysfunction Using Anti-TGF-β Immunotherapeutics by Market, Marisa, Tennakoon, Gayashan, Scaffidi, Marlena, Cook, David P, Angka, Leonard, Ng, Juliana, Tanese de Souza, Christiano, Kennedy, Michael A, Vanderhyden, Barbara C, Auer, Rebecca C

“…Natural Killer (NK) cell cytotoxicity and interferon-gamma (IFNγ) production are profoundly suppressed postoperatively. This dysfunction is associated with…”
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Hepatopancreaticobiliary Resection Arginine Immunomodulation (PRIMe) trial: protocol for a randomised phase II trial of the impact of perioperative immunomodulation on immune function following resection for hepatopancreaticobiliary malignancy by Behman, Ramy, Auer, Rebecca C, Bubis, Lev, Xu, Grace, Coburn, Natalie G, Martel, Guillaume, Hallet, Julie, Balaa, Fady, Law, Calvin, Bertens, Kimberly A, Abou Khalil, Jad, Karanicolas, Paul Jack

“…IntroductionSurgical stress results in immune dysfunction, predisposing patients to infections in the postoperative period and potentially increasing the risk…”
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New Anticancer Drugs: Reliably Assessing "Value" While Addressing High Prices by Stewart, David J, Bradford, John-Peter, Sehdev, Sandeep, Ramsay, Tim, Navani, Vishal, Rawson, Nigel S B, Jiang, Di Maria, Gotfrit, Joanna, Wheatley-Price, Paul, Liu, Geoffrey, Kaplan, Alan, Spadafora, Silvana, Goodman, Shaun G, Auer, Rebecca A C, Batist, Gerald

“…Countries face challenges in paying for new drugs. High prices are driven in part by exploding drug development costs, which, in turn, are driven by essential…”
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Safety and efficacy of autologous tumour cell vaccines as a cancer therapeutic to treat solid tumours and haematological malignancies: a meta-analysis protocol for two systematic reviews by Khan, Sarwat T, Montroy, Joshua, Forbes, Nicole, Bastin, Donald, Kennedy, Michael A, Diallo, Jean-Simon, Kekre, Natasha, Fergusson, Dean A, Lalu, Manoj, Auer, Rebecca C

“…IntroductionAutologous cancer cell vaccines are promising personalised immunotherapeutic options for solid and haematological malignancies that uses the…”
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Sepsis increases perioperative metastases in a murine model by Tai, Lee-Hwa, Ananth, Abhirami A, Seth, Rashmi, Alkayyal, Almohanad, Zhang, Jiqing, de Souza, Christiano Tanese, Staibano, Phillip, Kennedy, Michael A, Auer, Rebecca C

“…Cancer surgery can promote tumour metastases and worsen prognosis, however, the effect of perioperative complications on metastatic disease remains unclear. In…”
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A Method of Assessment of Human Natural Killer Cell Phenotype and Function in Whole Blood by Market, Marisa, Tennakoon, Gayashan, Ng, Juliana, Scaffidi, Marlena, de Souza, Christiano Tanese, Kennedy, Michael A, Auer, Rebecca C

“…The majority of data on human Natural Killer (NK) cell phenotype and function has been generated using cryopreserved peripheral blood mononuclear cells…”
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CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness by Abou-Hamad, John, Hodgins, Jonathan J., de Souza, Christiano T., Garland, Brennan, Labrèche, Cédrik, Marotel, Marie, Gibson, Cameron, Delisle, Samuel, Pascoal, Julia, Auer, Rebecca C., Ardolino, Michele, Sabourin, Luc A.

“…SOX10 is a key regulator of melanoma progression and promotes a melanocytic/differentiated state. Here we identified melanoma cell lines lacking SOX10…”
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Indications for hyperthermic intraperitoneal chemotherapy with cytoreductive surgery: a systematic review by Auer, Rebecca C., Sivajohanathan, Duvaraga, Biagi, Jim, Conner, James, Kennedy, Erin, May, Taymaa

“…The purpose of the present review was to describe evidence-based indications for hyperthermic intraperitoneal chemotherapy (HIPEC), with cytoreductive surgery…”
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Adjuvant melatonin for the prevention of recurrence and mortality following lung cancer resection (AMPLCaRe): A randomized placebo controlled clinical trial by Seely, Dugald, Legacy, Mark, Auer, Rebecca C., Fazekas, Anna, Delic, Edita, Anstee, Caitlin, Angka, Leonard, Kennedy, Michael A., Tai, Lee-Hwa, Zhang, Tinghua, Maziak, Donna E., Shamji, Farid M., Sundaresan, R. Sudhir, Gilbert, Sebastien, Villeneuve, P. James, Ashrafi, Ahmad S., Inculet, Richard, Yasufuku, Kazuhiro, Waddell, Thomas K., Finley, Christian, Shargall, Yaron, Plourde, Madelaine, Fergusson, Dean A., Ramsay, Tim, Seely, Andrew J.E.

“…Despite curative intent resection in patients with non-small cell lung cancer (NSCLC), recurrence leading to mortality remains too common. Melatonin has shown…”
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Correction to: Sepsis increases perioperative metastases in a murine model by Tai, Lee-Hwa, Ananth, Abhirami A, Seth, Rashmi, Alkayyal, Almohanad, Zhang, Jiqing, de Souza, Christiano Tanese, Staibano, Phillip, Kennedy, Michael A, Auer, Rebecca C

“…It has been highlighted that the original manuscript [1] contains a typesetting error in Fig. 1 and the Fig. 1c panel gas been inadvertently duplicated in…”
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