Search Results - "Audrey A. Darabie"

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model by McLaurin, JoAnne, Kierstead, Meredith E, Brown, Mary E, Hawkes, Cheryl A, Lambermon, Mark H L, Phinney, Amie L, Darabie, Audrey A, Cousins, Julian E, French, Janet E, Lan, Melissa F, Chen, Fusheng, Wong, Sydney S N, Mount, Howard T J, Fraser, Paul E, Westaway, David, George-Hyslop, Peter St

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Modulation of amyloid-β aggregation and toxicity by inosose stereoisomers by Nitz, Mark, Fenili, Daniela, Darabie, Audrey A, Wu, Ling, Cousins, Julian E, McLaurin, JoAnne

“…Amyloid-β (Aβ) aggregation and amyloid formation are key pathological features of Alzheimer's disease, and are considered to be two of the major contributing…”
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Contribution of simple saccharides to the stabilization of amyloid structure by Fung, Justin, Darabie, Audrey A., McLaurin, JoAnne

“…The use of osmolytes or chaperones to stabilize proteins/peptides that misfold in neurodegenerative diseases is an attractive concept for drug development. We…”
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Design of Peptide-based Inhibitors of Human Islet Amyloid Polypeptide Fibrillogenesis by Scrocchi, Louise A., Chen, Yan, Waschuk, Stefko, Wang, Feng, Cheung, Sindy, Darabie, Audrey A., McLaurin, JoAnne, Fraser, Paul E.

“…Human islet amyloid polypeptide (IAPP) is the major component of amyloid deposits found in the pancreas of over 90% of all cases of type-2 diabetes. We have…”
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alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis by Jo, Euijung, Darabie, Audrey A, Han, Kyung, Tandon, Anurag, Fraser, Paul E, McLaurin, JoAnne

“…alpha-Synuclein exists in two different compartments in vivo-- correspondingly existing as two different forms: a membrane-bound form that is predominantly…”
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Aβ42-Peptide Assembly on Lipid Bilayers by Yip, Christopher M., Darabie, Audrey A., McLaurin, JoAnne

“…One of the major pathological features of Alzheimer's disease (AD) is the presence of extracellular amyloid plaques that are composed predominantly of the…”
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Modulation of amyloid-[beta] aggregation and toxicity by inosose stereoisomers by Nitz, Mark, Fenili, Daniela, Darabie, Audrey A, Wu, Ling, Cousins, Julian E, McLaurin, JoAnne

“…Amyloid-[beta] (A[beta]) aggregation and amyloid formation are key pathological features of Alzheimer's disease, and are considered to be two of the major…”
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Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development by Fraser, P E, Darabie, A A, McLaurin, J A

“…In Alzheimer's disease, the major pathological features are diffuse and senile plaques that are primarily composed of the amyloid-beta (A beta) peptide. It has…”
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Cellular Membrane Composition Defines Aβ-Lipid Interactions by Waschuk, Stephen A., Elton, Elyssa A., Darabie, Audrey A., Fraser, Paul E., McLaurin, JoAnne

“…Alzheimer's disease pathology has demonstrated amyloid plaque formation associated with plasma membranes and the presence of intracellular amyloid-β (Aβ)…”
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Abeta42-peptide assembly on lipid bilayers by Yip, Christopher M, Darabie, Audrey A, McLaurin, JoAnne

“…One of the major pathological features of Alzheimer's disease (AD) is the presence of extracellular amyloid plaques that are composed predominantly of the…”
Get full text

Amyloid-β Interactions with Chondroitin Sulfate-derived Monosaccharides and Disaccharides by Fraser, Paul E., Darabie, Audrey A., McLaurin, JoAnne

“…In Alzheimer's disease, the major pathological features are diffuse and senile plaques that are primarily composed of the amyloid-β (Aβ) peptide. It has been…”
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Amyloid-β Interactions with Chondroitin Sulfate-derived Monosaccharides and Disaccharides by Paul E. Fraser, Audrey A. Darabie, JoAnne McLaurin

“…In Alzheimer's disease, the major pathological features are diffuse and senile plaques that are primarily composed of the amyloid-β (Aβ) peptide. It has been…”
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Cyclohexanehexol inhibitors of A[beta] aggregation prevent and reverse Alzheimer phenotype in a mouse model by McLaurin, JoAnne, Kierstead, Meredith E, Brown, Mary E, Hawkes, Cheryl A, Lambermon, Mark H L, Phinney, Amie L, Darabie, Audrey A, Cousins, Julian E, French, Janet E, Lan, Melissa F, Chen, Fusheng, Wong, Sydney S N, Mount, Howard T J, Fraser, Paul E, Westaway, David

“…When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into…”
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Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model by McLaurin, JoAnne, Kierstead, Meredith E, Brown, Mary E, Hawkes, Cheryl A, Lambermon, Mark H L, Phinney, Amie L, Darabie, Audrey A, Cousins, Julian E, French, Janet E, Lan, Melissa F, Chen, Fusheng, Wong, Sydney S N, Mount, Howard T J, Fraser, Paul E, Westaway, David, St George-Hyslop, Peter

“…When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into…”
Get full text

Cellular Membrane Composition Defines Aβ-Lipid Interactions by Stephen A. Waschuk, Elyssa A. Elton, Audrey A. Darabie, Paul E. Fraser, JoAnne McLaurin

“…Alzheimer's disease pathology has demonstrated amyloid plaque formation associated with plasma membranes and the presence of intracellular amyloid-β (Aβ)…”
Get full text

α‐Synuclein–synaptosomal membrane interactions by Jo, Euijung, Darabie, Audrey A., Han, Kyung, Tandon, Anurag, Fraser, Paul E., McLaurin, JoAnne

“…α‐Synuclein exists in two different compartments in vivo– correspondingly existing as two different forms: a membrane‐bound form that is predominantly…”
Get full text