Search Results - "Audouard, Emilie"

Microglia Express Mu Opioid Receptor: Insights From Transcriptomics and Fluorescent Reporter Mice by Maduna, Tando, Audouard, Emilie, Dembélé, Doulaye, Mouzaoui, Nejma, Reiss, David, Massotte, Dominique, Gaveriaux-Ruff, Claire

“…Microglia activation contributes to chronic pain and to the adverse effects of opiate use such as analgesic tolerance and opioid-induced hyperalgesia. Both mu…”
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Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide by Roeckel, Laurie-Anne, Utard, Valérie, Reiss, David, Mouheiche, Jinane, Maurin, Hervé, Robé, Anne, Audouard, Emilie, Wood, John N., Goumon, Yannick, Simonin, Frédéric, Gaveriaux-Ruff, Claire

“…Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). The…”
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Complete Correction of Brain and Spinal Cord Pathology in Metachromatic Leukodystrophy Mice by Audouard, Emilie, Oger, Valentin, Meha, Béatrix, Cartier, Nathalie, Sevin, Caroline, Piguet, Françoise

“…Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder characterized by accumulation of sulfatides in both glial cells and neurons. MLD results…”
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Delta Opioid Receptor in Astrocytes Contributes to Neuropathic Cold Pain and Analgesic Tolerance in Female Mice by Reiss, David, Maurin, Hervé, Audouard, Emilie, Martínez-Navarro, Miriam, Xue, Yaping, Herault, Yann, Maldonado, Rafael, Cabañero, David, Gaveriaux-Ruff, Claire

“…Background : The delta opioid receptor (DOR) contributes to pain control, and a major challenge is the identification of DOR populations that control pain,…”
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Modulation of Brain Cholesterol Metabolism through CYP46A1 Overexpression for Rett Syndrome by Audouard, Emilie, Khefif, Nicolas, Gillet-Legrand, Béatrix, Nobilleau, Fanny, Bouazizi, Ouafa, Stanga, Serena, Despres, Gaëtan, Alves, Sandro, Lamazière, Antonin, Cartier, Nathalie, Piguet, Françoise

“…Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutation in the X-linked gene methyl-CpG-binding protein 2 (Mecp2), a ubiquitously…”
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Dose-response evaluation of intravenous gene therapy in a symptomatic mouse model of metachromatic leukodystrophy by Audouard, Emilie, Khefif, Nicolas, Mansat, Charlotte, Nelcha, Océane, Banchi, Elena-Gaia, Lupiet, Camille, Farabos, Dominique, Lamaziere, Antonin, Sevin, Caroline, Piguet, Françoise

“…Metachromatic leukodystrophy (MLD) is a rare, autosomal recessive neurodegenerative disease caused by deficient activity of the lysosomal enzyme arylsulfatase…”
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Vascular endothelial growth factor-loaded injectable hydrogel enhances plasticity in the injured spinal cord by des Rieux, Anne, De Berdt, Pauline, Ansorena, Eduardo, Ucakar, Bernard, Damien, Jacobs, Schakman, Olivier, Audouard, Emilie, Bouzin, Caroline, Auhl, Dietmar, Simón-Yarza, Teresa, Feron, Olivier, Blanco-Prieto, Maria J., Carmeliet, Peter, Bailly, Christian, Clotman, Fréderic, Préat, Véronique

“…We hypothesized that vascular endothelial growth factor (VEGF)‐containing hydrogels that gelify in situ after injection into a traumatized spinal cord, could…”
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Optimized Protocol for Subcutaneous Implantation of Encapsulated Cells Device and Evaluation of Biocompatibility by Audouard, Emilie, Rousselot, Lisa, Folcher, Marc, Cartier, Nathalie, Piguet, Françoise

“…Improving a drug delivery system is critical to treat central nervous system disorders. Here we studied an innovative approach based on implantation of a…”
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The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions by Audouard, Emilie, Schakman, Olivier, René, Frédérique, Huettl, Rosa-Eva, Huber, Andrea B, Loeffler, Jean-Philippe, Gailly, Philippe, Clotman, Frédéric

“…The neuromuscular junctions are the specialized synapses whereby spinal motor neurons control the contraction of skeletal muscles. The formation of the…”
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Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice by Reiss, David, Maduna, Tando, Maurin, Hervé, Audouard, Emilie, Gaveriaux‐Ruff, Claire

“…A major challenge in medicine is developing potent pain therapies without the adverse effects of opiates. Neuroinflammation and in particular microglial…”
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Cell-based device provides effective therapeutic strategy to treat metachromatic leukodystrophy by Audouard, Emilie, Banchi, Elena Gaia, Alonso, Rafael, Jacquot, Sylvie, Lamaziere, Antonin, Sevin, Caroline, Piguet, Françoise

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Intravenous gene therapy using AAVPHP.eB for metachromatic leukodystrophy by Audouard, Emilie, Banchi, Elena Gaia, Alonso, Rafael, Lamaziere, Antonin, Sevin, Caroline, Piguet, Françoise

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The Challenge of Gene Therapy for Neurological Diseases: Strategies and Tools to Achieve Efficient Delivery to the Central Nervous System by Piguet, Françoise, de Saint Denis, Timothée, Audouard, Emilie, Beccaria, Kevin, André, Arthur, Wurtz, Guillaume, Schatz, Raphael, Alves, Sandro, Sevin, Caroline, Zerah, Michel, Cartier, Nathalie

“…For more than 10 years, gene therapy for neurological diseases has experienced intensive research growth and more recently therapeutic interventions for…”
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High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo by Audouard, Emilie, Houben, Sarah, Masaracchia, Caterina, Yilmaz, Zehra, Suain, Valérie, Authelet, Michèle, De Decker, Robert, Buée, Luc, Boom, Alain, Leroy, Karelle, Ando, Kunie, Brion, Jean-Pierre

“…In Alzheimer disease, the development of tau pathology follows neuroanatomically connected pathways, suggesting that abnormal tau species might recruit normal…”
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Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis by Audouard, Emilie, Michel, Fanny, Pierroz, Vanessa, Kim, Taeuk, Rousselot, Lisa, Gillet-Legrand, Béatrix, Dufayet-Chauffaut, Gaëlle, Buchmann, Peter, Florea, Michael, Khel, Alexander, Altynbekova, Kamilya, Delgaldo, Claudia, Escudero, Encarna, Soler, Alejandra Ben Aissa, Cartier, Nathalie, Piguet, Francoise, Folcher, Marc

“…Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells…”
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Motor Deficit in a Tauopathy Model Is Induced by Disturbances of Axonal Transport Leading to Dying-Back Degeneration and Denervation of Neuromuscular Junctions by Audouard, Emilie, Van Hees, Laura, Suain, Valérie, Yilmaz, Zehra, Poncelet, Luc, Leroy, Karelle, Brion, Jean-Pierre

“…Several neurodegenerative diseases are characterized by both cognitive and motor deficits associated with accumulation of tau aggregates in brain, brainstem,…”
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APP‐dependent glial cell line‐derived neurotrophic factor gene expression drives neuromuscular junction formation by Stanga, Serena, Zanou, Nadège, Audouard, Emilie, Tasiaux, Bernadette, Contino, Sabrina, Vandermeulen, Gaëlle, René, Frédérique, Loeffler, Jean‐Philippe, Clotman, Frédéric, Gailly, Philippe, Dewachter, Use, Octave, Jean‐Noël, Kienlen‐Campard, Pascal

“…Besides its crucial role in the pathogenesis of Alzheimer's disease, the knowledge of amyloid precursor protein (APP) physiologic functions remains…”
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The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development by Audouard, Emilie, Schakman, Olivier, Ginion, Audrey, Bertrand, Luc, Gailly, Philippe, Clotman, Frédéric

“…The Onecut (OC) family of transcription factors comprises three members in mammals, namely HNF-6 (or OC-1), OC-2 and OC-3. During embryonic development, these…”
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Vascular endothelial growth factor-loaded injectable hydrogel enhances plasticity in the injured spinal cord by des Rieux, Anne, De Berdt, Pauline, Ansorena, Eduardo, Ucakar, Bernard, Damien, Jacobs, Schakman, Olivier, Audouard, Emilie, Bouzin, Caroline, Auhl, Dietmar, Simón-Yarza, Teresa, Feron, Olivier, Blanco-Prieto, Maria J., Carmeliet, Peter, Bailly, Christian, Clotman, Fréderic, Préat, Véronique

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Stereotaxic injection of fibrillar PHF from Alzheimer brain induces propagation of argyrophilic grains constituted of murine tau in mouse brains by Sarah, Houben, Emilie, Audouard, Caterina, Masaracchia, Zehra, Yilmaz, Valérie, Suain, Michèle, Authelet, Robert, De Decker, Luc, Buée, Alain, Boom, Karelle, Leroy, Kunie, Ando, Jean-Pierre, Brion

“…Abstract only…”
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