Search Results - "Audia, Jonathon P."

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function by Audia, Jonathon P., Yang, Xi-Ming, Crockett, Edward S., Housley, Nicole, Haq, Ehtesham Ul, O’Donnell, Kristen, Cohen, Michael V., Downey, James M., Alvarez, Diego F.

“…Patients with acute myocardial infarction receive a P2Y 12 receptor antagonist prior to reperfusion, a treatment that has reduced, but not eliminated,…”
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Perspectives on the Pseudomonas aeruginosa Type III Secretion System Effector ExoU and Its Subversion of the Host Innate Immune Response to Infection by Hardy, Kierra S, Tessmer, Maxx H, Frank, Dara W, Audia, Jonathon P

“…is an opportunistic, Gram-negative pathogen and an important cause of hospital acquired infections, especially in immunocompromised patients. Highly virulent…”
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Tau and Aβ42 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: A prospective exploratory study by Renema, Phoibe, Pittet, Jean-Francois, Brandon, Angela P, Leal, Jr, Sixto M, Gu, Steven, Promer, Grace, Hackney, Andrew, Braswell, Phillip, Pickering, Andrew, Rafield, Grace, Voth, Sarah, Balczon, Ron, Lin, Mike T, Morrow, K Adam, Bell, Jessica, Audia, Jonathon P, Alvarez, Diego, Stevens, Troy, Wagener, Brant M

“…Bacterial pneumonia and sepsis are both common causes of end-organ dysfunction, especially in immunocompromised and critically ill patients. Pre-clinical data…”
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Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity by Yang, Xi-Ming, Cohen, Michael V, Sayner, Sarah, Audia, Jonathon P, Downey, James M

“…To study the relationship between caspase-1/4 and reperfusion injury, we measured infarct size (IS) in isolated mouse hearts undergoing 50 min global…”
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Infection‐induced endothelial amyloids impair memory by Balczon, Ron, Pittet, Jean‐Francois, Wagener, Brant M., Moser, Stephen A., Voth, Sarah, Vorhees, Charles V., Williams, Michael T., Bridges, James P., Alvarez, Diego F., Koloteva, Anna, Xu, Yuanyuan, Zha, Xiang‐Ming, Audia, Jonathon P., Stevens, Troy, Lin, Mike T.

“…ABSTRACTPatients with nosocomial pneumonia exhibit elevated levels of neurotoxic amyloid and tau proteins in the cerebrospinal fluid (CSF). In vitro studies…”
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ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection by Hardy, Kierra S, Tuckey, Amanda N, Renema, Phoibe, Patel, Mita, Al-Mehdi, Abu-Bakr, Spadafora, Domenico, Schlumpf, Cody A, Barrington, Robert A, Alexeyev, Mikhail F, Stevens, Troy, Pittet, Jean-Francois, Wagener, Brant M, Simmons, Jon D, Alvarez, Diego F, Audia, Jonathon P

“…The Gram-negative, opportunistic pathogen utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied…”
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Exoenzyme Y Contributes to End-Organ Dysfunction Caused by Pseudomonas aeruginosa Pneumonia in Critically Ill Patients: An Exploratory Study by Wagener, Brant M, Anjum, Naseem, Christiaans, Sarah C, Banks, Morgan E, Parker, Jordan C, Threet, Adam T, Walker, Rashidra R, Isbell, Kayla D, Moser, Stephen A, Stevens, Troy, Alexeyev, Mikhail F, Audia, Jonathon P, Richter, Wito, Hardy, Kierra S, Saleh, Lina Abou, Morgan, Charity, Pittet, Jean-François

“…is an opportunistic pathogen that causes pneumonia in immunocompromised and intensive care unit (ICU) patients. During host infection, upregulates the type III…”
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Dual Mechanisms of Metabolite Acquisition by the Obligate Intracytosolic Pathogen Rickettsia prowazekii Reveal Novel Aspects of Triose Phosphate Transport by Frohlich, Kyla M, Audia, Jonathon P

“…Rickettsia prowazekii is an obligate intracytosolic pathogen and the causative agent of epidemic typhus fever in humans. As an evolutionary model of…”
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Amyloid-β and caspase-1 are indicators of sepsis and organ injury by Tuckey, Amanda N, Brandon, Arcole, Eslaamizaad, Yasaman, Siddiqui, Waqar, Nawaz, Talha, Clarke, Christopher, Sutherland, Erica, Williams, Veronica, Spadafora, Domenico, Barrington, Robert A, Alvarez, Diego F, Mulekar, Madhuri S, Simmons, Jon D, Fouty, Brian W, Audia, Jonathon P

“…Sepsis is a life-threatening condition that results from a dysregulated host response to infection, leading to organ dysfunction. Despite the prevalence and…”
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In the absence of effector proteins, the Pseudomonas aeruginosa type three secretion system needle tip complex contributes to lung injury and systemic inflammatory responses by Audia, Jonathon P, Lindsey, Ashley S, Housley, Nicole A, Ochoa, Courtney R, Zhou, Chun, Toba, Michie, Oka, Masahiko, Annamdevula, Naga S, Fitzgerald, Meshann S, Frank, Dara W, Alvarez, Diego F

“…Herein we describe a pathogenic role for the Pseudomonas aeruginosa type three secretion system (T3SS) needle tip complex protein, PcrV, in causing lung…”
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Study of the Five Rickettsia prowazekii Proteins Annotated as ATP/ADP Translocases (Tlc): Only Tlc1 Transports ATP/ADP, While Tlc4 and Tlc5 Transport Other Ribonucleotides by AUDIO, Jonathon P, WINKLER, Herbert H

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DNA Microarray Analysis of the Heat Shock Transcriptome of the Obligate Intracytoplasmic Pathogen Rickettsia prowazekii by Audia, Jonathon P, Patton, Mary C, Winkler, Herbert H

“…Here we present the first oligonucleotide DNA microarray analysis of global gene expression changes in the obligate intracytoplasmic pathogen Rickettsia…”
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Bariatric surgery improves the circulating numbers and biological activity of late outgrowth endothelial progenitor cells by Richards, William O., M.D, Prutzman, Kelley Bose, R.N, B.S.N, O’Hea, Martha F., B.Sc, Audia, Jonathon P., Ph.D, Alvarez, Diego F., M.D., Ph.D

“…Abstract Background Although the salutary effects of bariatric surgery as a treatment for excess weight and type 2 diabetes are established, there is scant…”
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The Rickettsia prowazekii ExoU Homologue Possesses Phospholipase A1 (PLA1), PLA2, and Lyso-PLA2 Activities and Can Function in the Absence of Any Eukaryotic Cofactors In Vitro by HOUSLEY, Nicole A, WINKLER, Herbert H, AUDIA, Jonathon P

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Rickettsia prowazekii Uses an sn-Glycerol-3-Phosphate Dehydrogenase and a Novel Dihydroxyacetone Phosphate Transport System To Supply Triose Phosphate for Phospholipid Biosynthesis by Frohlich, Kyla M, Roberts, Rosemary A W, Housley, Nicole A, Audia, Jonathon P

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Autoinduction of the ompR response regulator by acid shock and control of the Salmonella enterica acid tolerance response by Bang, Iel Soo, Audia, Jonathon P., Park, Yong Keun, Foster, John W.

“…Summary Salmonella enterica serovar Typhimurium periodically experiences acid stress in a variety of host and non‐host environments. An encounter with…”
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Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions by Voth, Sarah, Gwin, Meredith, Francis, Christopher Michael, Balczon, Ron, Frank, Dara W., Pittet, Jean‐Francois, Wagener, Brant M., Moser, Stephen A., Alexeyev, Mikhail, Housley, Nicole, Audia, Jonathon P., Piechocki, Scott, Madera, Kayla, Simmons, Autumn, Crawford, Michaela, Stevens, Troy

“…Pseudomonas aeruginosa infection elicits the production of cytotoxic amyloids from lung endothelium, yet molecular mechanisms of host‐pathogen interaction that…”
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Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction by Peng, Xiaohua, Kim, Jooyoung, Gupta, Gayatri, Agaronyan, Karen, Mankowski, Madeleine C, Korde, Asawari, Takyar, Shervin S, Shin, Hyeon Jun, Habet, Victoria, Voth, Sarah, Audia, Jonathon P, Chang, De, Liu, Xinran, Wang, Lin, Cai, Ying, Tian, Xuefei, Ishibe, Shuta, Kang, Min-Jong, Compton, Susan, Wilen, Craig B, Dela Cruz, Charles S, Sharma, Lokesh

“…Postviral bacterial infections are a major health care challenge in coronavirus infections, including COVID-19; however, the coronavirus-specific mechanisms of…”
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Deleterious effects of plasma-derived cellular debris in a porcine model of hemorrhagic shock by Buckley, Colin T., Lee, Yannleei L., Michele Schuler, A., Langley, Raymond J., Kutcher, Matthew E., Barrington, Robert, Audia, Jonathon P., Simmons, Jon D.

“…Recent studies identify large quantities of inflammatory cellular debris within Fresh Frozen Plasma (FFP). As FFP is a mainstay of hemorrhagic shock…”
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The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model by Hardy, Kierra S, Tuckey, Amanda N, Housley, Nicole A, Andrews, Joel, Patel, Mita, Al-Mehdi, Abu-Bakr, Barrington, Robert A, Cassel, Suzanne L, Sutterwala, Fayyaz S, Audia, Jonathon P

“…Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P…”
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