Search Results - "Audi, H."

Integrated computational model of the bioenergetics of isolated lung mitochondria by Zhang, Xiao, Dash, Ranjan K, Jacobs, Elizabeth R, Camara, Amadou K S, Clough, Anne V, Audi, Said H

“…Integrated computational modeling provides a mechanistic and quantitative framework for describing lung mitochondrial bioenergetics. Thus, the objective of…”
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Aortic Remodeling Kinetics in Response to Coarctation-Induced Mechanical Perturbations by Ghorbannia, Arash, Maadooliat, Mehdi, Woods, Ronald K, Audi, Said H, Tefft, Brandon J, Chiastra, Claudio, Ibrahim, El Sayed H, LaDisa, John F

“…Coarctation of the aorta (CoA; constriction of the proximal descending thoracic aorta) is among the most common congenital cardiovascular defects…”
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Etiology of Community-Acquired Pneumonia in Hospitalized School-Age Children: Evidence for High Prevalence of Viral Infections by Tsolia, M. N., Psarras, S., Bossios, A., Audi, H., Paldanius, M., Gourgiotis, D., Kallergi, K., Kafetzis, D. A., Constantopoulos, A., Papadopoulos, N. G.

“…Background. Community-acquired pneumonia (CAP) in young children is most commonly associated with viral infections; however, the role of viruses in CAP of…”
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Substrate- and Calcium-Dependent Differential Regulation of Mitochondrial Oxidative Phosphorylation and Energy Production in the Heart and Kidney by Zhang, Xiao, Tomar, Namrata, Kandel, Sunil M, Audi, Said H, Cowley, Jr, Allen W, Dash, Ranjan K

“…Mitochondrial dehydrogenases are differentially stimulated by Ca . Ca has also diverse regulatory effects on mitochondrial transporters and other enzymes…”
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Integrated Computational Model of Lung Tissue Bioenergetics by Zhang, Xiao, Dash, Ranjan K, Clough, Anne V, Xie, Dexuan, Jacobs, Elizabeth R, Audi, Said H

“…Altered lung tissue bioenergetics plays a key role in the pathogenesis of lung diseases. A wealth of information exists regarding the bioenergetic processes in…”
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A size‐modified poisson–boltzmann ion channel model in a solvent of multiple ionic species: Application to voltage‐dependent anion channel by Xie, Dexuan, Audi, Said H., Dash, Ranjan K.

“…We present a new size‐modified Poisson–Boltzmann ion channel (SMPBIC) model and use it to calculate the electrostatic potential, ionic concentrations, and…”
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Stent design properties and deployment ratio influence indexes of wall shear stress: a three-dimensional computational fluid dynamics investigation within a normal artery by LaDisa, John F., Jr, Olson, Lars E, Guler, Ismail, Hettrick, Douglas A, Audi, Said H, Kersten, Judy R, Warltier, David C, Pagel, Paul S

“…1 Departments of Anesthesiology, 4 Pulmonary and Critical Care Medicine, 5 Pharmacology and Toxicology, and 6 Medicine, Division of Cardiovascular Diseases,…”
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Effects of ROS pathway inhibitors and NADH and FADH2 linked substrates on mitochondrial bioenergetics and ROS emission in the heart and kidney cortex and outer medulla by Sadri, Shima, Tomar, Namrata, Yang, Chun, Audi, Said H., Cowley, Allen W., Dash, Ranjan K.

“…Mitochondria are major sources of reactive oxygen species (ROS), which play important roles in both physiological and pathological processes. However, the…”
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Mitochondrial function in lungs of rats with different susceptibilities to hyperoxia-induced acute lung injury by Taheri, Pardis, Dave, Devanshi D, Dash, Ranjan K, Sharma, Guru P, Clough, Anne V, Jacobs, Elizabeth R, Audi, Said H

“…Adult rats exposed to hyperoxia (>95% O ) die from respiratory failure in 60-72 h. However, rats preconditioned with >95% O for 48 h followed by 24 h in room…”
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Quantification of mitochondrial membrane potential in the isolated rat lung using rhodamine 6G by Audi, Said H, Cammarata, Anthony, Clough, Anne V, Dash, Ranjan K, Jacobs, Elizabeth R

“…Mitochondrial membrane potential (Δψ ) plays a key role in vital mitochondrial functions, and its dissipation is a hallmark of mitochondrial dysfunction. The…”
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In vivo molecular imaging stratifies rats with different susceptibilities to hyperoxic acute lung injury by Audi, Said H, Taheri, Pardis, Zhao, Ming, Hu, Kurt, Jacobs, Elizabeth R, Clough, Anne V

“…Tc-hexamethylpropyleneamine oxime (HMPAO) and Tc-duramycin in vivo imaging detects pulmonary oxidative stress and cell death, respectively, in rats exposed to…”
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Assessment of Protection Offered By the NRF2 Pathway Against Hyperoxia-Induced Acute Lung Injury in NRF2 Knockout Rats by Audi, Said H., Jacobs, Elizabeth R., Taheri, Pardis, Ganesh, Swetha, Clough, Anne V.

“…Nuclear factor erythroid 2-related factor (Nrf2) is a redox-sensitive transcription factor that responds to oxidative stress by activating expressions of key…”
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Substrate-dependent differential regulation of mitochondrial bioenergetics in the heart and kidney cortex and outer medulla by Tomar, Namrata, Zhang, Xiao, Kandel, Sunil M, Sadri, Shima, Yang, Chun, Liang, Mingyu, Audi, Said H, Cowley, Jr, Allen W, Dash, Ranjan K

“…The kinetics and efficiency of mitochondrial oxidative phosphorylation (OxPhos) can depend on the choice of respiratory substrates. Furthermore, potential…”
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In vivo Molecular Imaging Stratifies Rats with Different Susceptibilities to Hyperoxic Acute Lung Injury by Clough, Anne V., Taheri, Pardis, Zhao, Ming, Jacobs, Elizabeth R., Audi, Said H.

“…Objectives Acute Respiratory Distress Syndrome (ARDS) is one of the most frequent causes of admission to medical intensive care units. It carries a mortality…”
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Reverse Electron Transfer is a More Dominant Source of Mitochondrial ROS Production in the Heart and Kidney Outer Medulla than in the Kidney Cortex by Sadri, Shima, Tomar, Namrata, Zhang, Xiao, Yang, Chun, Audi, Said H., Cowley, Allen W., Dash, Ranjan K.

“…Rationale Reactive oxygen species (ROS; e.g. O2·– and H2O2) play important roles in both physiological and pathophysiological processes. ROS in low…”
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Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins by Ma, Cui, Beyer, Andreas M, Durand, Matthew, Clough, Anne V, Zhu, Daling, Norwood Toro, Laura, Terashvili, Maia, Ebben, Johnathan D, Hill, R Blake, Audi, Said H, Medhora, Meetha, Jacobs, Elizabeth R

“…OBJECTIVE—We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. APPROACH AND…”
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Autophagy, TERT, and mitochondrial dysfunction in hyperoxia by Beyer, Andreas M, Norwood Toro, Laura E, Hughes, William E, Young, Micaela, Clough, Anne V, Gao, Feng, Medhora, Meetha, Audi, Said H, Jacobs, Elizabeth R

“…Ventilation with gases containing enhanced fractions of oxygen is the cornerstone of therapy for patients with hypoxia and acute respiratory distress syndrome…”
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Depolarized mitochondrial membrane potential and protection with duroquinone in isolated perfused lungs from rats exposed to hyperoxia by Audi, Said H, Ganesh, Swetha, Taheri, Pardis, Zhang, Xiao, Dash, Ranjan K, Clough, Anne V, Jacobs, Elizabeth R

“…Dissipation of mitochondrial membrane potential (Δψ ) is a hallmark of mitochondrial dysfunction. Our objective was to use a previously developed…”
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A thermodynamically-constrained mathematical model for the kinetics and regulation of NADPH oxidase 2 complex-mediated electron transfer and superoxide production by Tomar, Namrata, Sadri, Shima, Cowley, Allen W., Yang, Chun, Quryshi, Nabeel, Pannala, Venkat R., Audi, Said H., Dash, Ranjan K.

“…Reactive oxygen species (ROS) play an important role in cell signaling, growth, and immunity. However, when produced in excess, they are toxic to the cell and…”
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OPTICAL IMAGING OF LIPOPOLYSACCHARIDE-INDUCED OXIDATIVE STRESS IN ACUTE LUNG INJURY FROM HYPEROXIA AND SEPSIS by SEPEHR, REYHANEH, AUDI, SAID H., MALEKI, SEPIDEH, STANISZEWSKI, KEVIN, EIS, ANNIE L., KONDURI, GIRIJA G., RANJI, MAHSA

“…Reactive oxygen species (ROS) have been implicated in the pathogenesis of many acute and chronic pulmonary disorders such as acute lung injury (ALI) in adults…”
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