Search Results - "Auckland, Philip"
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Building an integrated model of chromosome congression
Published in Journal of cell science (15-09-2015)“…A universal feature of mitosis is that all chromosomes become aligned at the spindle equator--the halfway point between the two spindle poles--prior to…”
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CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes
Published in The Journal of cell biology (04-05-2020)“…Accurate chromosome segregation demands efficient capture of microtubules by kinetochores and their conversion to stable bioriented attachments that can…”
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Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment
Published in The Journal of cell biology (05-06-2017)“…Kinetochores mediate chromosome congression by either sliding along the lattice of spindle microtubules or forming end-on attachments to their depolymerizing…”
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Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80
Published in Molecular cell (20-09-2018)“…The approximately thirty core subunits of kinetochores assemble on centromeric chromatin containing the histone H3 variant CENP-A and connect chromosomes with…”
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Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways
Published in Journal of cell science (01-01-2015)“…A key step of mitosis is the congression of chromosomes to the spindle equator. Congression is driven by at least two distinct mechanisms: (1) kinetochores…”
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Lis1-dynein drives corona compaction and limits erroneous microtubule attachment at kinetochores
Published in Journal of cell science (01-03-2023)“…Mitotic cell division requires that kinetochores form microtubule attachments that can segregate chromosomes and control mitotic progression via the spindle…”
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Molecular analysis of chromosome movement by microtubule depolymerisation-coupled pulling
Published 01-01-2016Get full text
Dissertation