Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana

Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana

The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group “A”...

Full description

Saved in:
Bibliographic Details
Published in:Advances in hematology Vol. 2016; no. 2016; pp. 1 - 4
Main Authors: Nwaefuna, Ekene K., Prah, James, Aubyn, Edmond, Afoakwah, Richmond, Boampong, J. N.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 2016
Hindawi Limited
Subjects:
Anemia
Antigens
Blood groups
Erythrocytes
Hemoglobin
Infections
Laboratories
Malaria
Medical prognosis
Parasites
Pathogenesis
Tropical diseases
Ghana
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group “A” have been found to be highly susceptible to falciparum malaria whereas blood group “O” is said to confer protection against complicated cases. We analyzed samples from 293 young children less than six years old with malaria in the Korle-Bu Teaching Hospital in Accra, Ghana. It was observed that group O was present in about 16.1% of complicated cases weighed against 40.9% of uncomplicated controls. Individuals with complicated malaria were about twice likely to be of blood groups A and B compared to group O (A versus O, OR = 1.90, 95% CI = 1.59–2.26, P < 0.0001 ; B versus O, OR = 1.82. 95% CI = 1.57–2.23, P < 0.0001 ). Blood group O participants with complicated diseases had low parasitaemia compared to the other blood groups ( P < 0.0001 ). This may give blood group O individuals a survival advantage over the other groups in complicated malaria as suggested. Participants with complicated falciparum malaria were generally anaemic and younger than those with uncomplicated disease.
Bibliography:Academic Editor: Aldo Roccaro
ISSN:1687-9104
1687-9112
DOI:10.1155/2016/5368793