Search Results - "Auberson, Yves P."

Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para‐Phenyl Bioisosteres by Auberson, Yves P., Brocklehurst, Cara, Furegati, Markus, Fessard, Thomas C., Koch, Guido, Decker, Andrea, La Vecchia, Luigi, Briard, Emmanuelle

“…Bicycloalkyl groups have been previously described as phenyl group bioisosteres. This article describes the synthesis of new building blocks allowing their…”
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The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression by Jiménez-Sánchez, Laura, Campa, Leticia, Auberson, Yves P, Adell, Albert

“…Paradoxically, N-methyl-D-aspartate (NMDA) receptor antagonists are used to model certain aspects of schizophrenia as well as to treat refractory depression…”
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Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study by DESCHWANDEN, Alexandra, KAROLEWICZ, Beata, BUCK, Alfred, HASLER, Gregor, FEYISSA, Anteneh M, TREYER, Valerie, AMETAMEY, Simon M, JOHAYEM, Anass, BURGER, Cyrill, AUBERSON, Yves P, SOVAGO, Judit, STOCKMEIER, Craig A

“…Clinical and preclinical evidence suggests a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5)…”
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Regional brain mGlu5 receptor occupancy following single oral doses of mavoglurant as measured by [11C]-ABP688 PET imaging in healthy volunteers by Streffer, Johannes, Treyer, Valerie, Buck, Alfred, Ametamey, Simon M., Blagoev, Milen, Maguire, Ralph P, Gautier, Aurélie, Auberson, Yves P., Schmidt, Mark E., Vranesic, Ivan-Toma, Gomez-Mancilla, Baltazar, Gasparini, Fabrizio

“…•Mavoglurant binds to same allosteric site on mGluR5 as the radioligand [11C]-ABP688.•Mavoglurant penetrates brain and induces mGluR5 receptors occupancy in…”
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Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity by Liu, Lidong, Wong, Tak Pan, Pozza, Mario F., Lingenhoehl, Kurt, Wang, Yushan, Sheng, Morgan, Auberson, Yves P., Wang, Yu Tian

“…Activation of N-methyl-D-aspartate subtype glutamate receptors (NMDARs) is required for long-term potentiation (LTP) and long-term depression (LTD) of…”
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Enhanced Astrocytic Ca2+ Signals Contribute to Neuronal Excitotoxicity after Status Epilepticus by Ding, Shinghua, Fellin, Tommaso, Zhu, Yingzi, Lee, So-Young, Auberson, Yves P, Meaney, David F, Coulter, Douglas A, Carmignoto, Giorgio, Haydon, Philip G

“…Status epilepticus (SE), an unremitting seizure, is known to cause a variety of traumatic responses including delayed neuronal death and later cognitive…”
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Medicinal Chemists Don't Just Make Drugs - The Art of Developing Low Molecular Weight Imaging Agents in Switzerland by Auberson, Yves P

“…Radiolabeled molecular imaging agents are useful to study drug distribution, target engagement and disease progression in human patients. Medicinal chemists…”
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Zinc Modulates Bidirectional Hippocampal Plasticity by Effects on NMDA Receptors by Izumi, Yukitoshi, Auberson, Yves P, Zorumski, Charles F

“…Zinc has complex effects on NMDA receptors (NMDARs) and may be an endogenous modulator of synaptic plasticity. In the CA1 region of rat hippocampal slices, we…”
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mGluR5 stimulates gliotransmission in the nucleus accumbens by D'Ascenzo, Marcello, Fellin, Tommaso, Terunuma, Miho, Revilla-Sanchez, Raquel, Meaney, David F, Auberson, Yves P, Moss, Stephen J, Haydon, Philip G

“…Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-administration and drug-seeking behavior, there is limited knowledge of the…”
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Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist by Gordillo-Salas, Marta, Pilar-Cuéllar, Fuencisla, Auberson, Yves P., Adell, Albert

“…In a previous study we found that the preferring GluN2A receptor antagonist, NVP-AAM077, elicited rapid antidepressant-like effects in the forced swim test…”
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Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression by Massey, Peter V, Johnson, Benjamin E, Moult, Peter R, Auberson, Yves P, Brown, Malcolm W, Molnar, Elek, Collingridge, Graham L, Bashir, Zafar I

“…It is widely believed that long-term depression (LTD) and its counterpart, long-term potentiation (LTP), involve mechanisms that are crucial for learning and…”
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Fostering Research Synergies between Chemists in Swiss Academia and at Novartis by Meyer, Arndt, Baeschlin, Daniel, Brocklehurst, Cara E., Duckely, Myriam, Gallou, Fabrice, Lovelle, Lucie E., Parmentier, Michael, Schlama, Thierry, Snajdrova, Radka, Auberson, Yves P.

“…We present a short overview of the way Novartis chemists interact and collaborate with the academic chemistry community in Switzerland. This article…”
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Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor–Targeted PET Imaging by Haider, Ahmed, Herde, Adrienne Müller, Krämer, Stefanie D, Varisco, Jasmine, Keller, Claudia, Frauenknecht, Katrin, Auberson, Yves P, Temme, Louisa, Robaa, Dina, Sippl, Wolfgang, Schibli, Roger, Wünsch, Bernhard, Mu, Linjing, Ametamey, Simon M

“…The study aims to investigate the performance characteristics of the enantiomers of 11C-Me-NB1, a recently reported PET imaging probe that targets the GluN2B…”
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Double Dissociation of Spike Timing–Dependent Potentiation and Depression by Subunit-Preferring NMDA Receptor Antagonists in Mouse Barrel Cortex by Banerjee, Abhishek, Meredith, Rhiannon M., Rodríguez-Moreno, Antonio, Mierau, Susanna B., Auberson, Yves P., Paulsen, Ole

“…Spike timing–dependent plasticity (STDP) is a strong candidate for an N-methyl-D-aspartate (NMDA) receptor-dependent form of synaptic plasticity that could…”
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Upregulation of Forebrain NMDA NR2B Receptors Contributes to Behavioral Sensitization after Inflammation by Wu, Long-Jun, Toyoda, Hiroki, Zhao, Ming-Gao, Lee, Yong-Seok, Tang, Jianrong, Ko, Shanelle W, Jia, Yong Heng, Shum, Fanny W. F, Zerbinatti, Celina V, Bu, Guojun, Wei, Feng, Xu, Tian-Le, Muglia, Louis J, Chen, Zhou-Feng, Auberson, Yves P, Kaang, Bong-Kiun, Zhuo, Min

“…Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain. However, it is not known…”
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MS565: A SPECT Tracer for Evaluating the Brain Penetration of BAF312 (Siponimod) by Briard, Emmanuelle, Rudolph, Bettina, Desrayaud, Sandrine, Krauser, Joel A., Auberson, Yves P.

“…BAF312 (siponimod) is a sphingosine‐1‐phosphate (S1P) receptor modulator in clinical development for the treatment of multiple sclerosis, with faster…”
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Blockade of NMDA Receptors 2A Subunit in the Dorsal Striatum Impairs the Learning of a Complex Motor Skill by LEMAY-CLERMONT, Julie, ROBITAILLE, Christine, AUBERSON, Yves P, BUREAU, Genevieve, CYR, Michel

“…Accumulating evidence proposes that the striatum, known to control voluntary movement, may also play a role in learning and memory. Striatum learning is…”
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EFMC, Medicinal Chemistry and Chemical Biology in Europe by Auberson, Yves P.

“…This article is a reflection on the development of medicinal chemistry and chemical biology in Europe, and how the European Federation for Medicinal Chemistry…”
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ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: Identification, in vitro pharmacology, pharmacokinetic and biodistribution studies by Hintermann, Samuel, Vranesic, Ivo, Allgeier, Hans, Brülisauer, Armin, Hoyer, Daniel, Lemaire, Michel, Moenius, Thomas, Urwyler, Stephan, Whitebread, Steven, Gasparini, Fabrizio, Auberson, Yves P.

“…[ 11C]ABP688 ( 2) has recently been demonstrated to be a useful PET tracer for in vivo imaging of the metabotropic glutamate receptors type 5 (mGluR5) in…”
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The Different Effects on Recognition Memory of Perirhinal Kainate and NMDA Glutamate Receptor Antagonism: Implications for Underlying Plasticity Mechanisms by Barker, Gareth R. I, Warburton, E. Clea, Koder, Timothy, Dolman, Nigel P, More, Julia C. A, Aggleton, John P, Bashir, Zafar I, Auberson, Yves P, Jane, David E, Brown, Malcolm W

“…To investigate the involvement of different types of glutamate receptors in recognition memory, selective antagonists of NMDA and kainate receptors were…”
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