Search Results - "Au Yeung, Tsun"

Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer by Whalen, Kerry A, White, Brian H, Quinn, James M, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun P, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle M, Oller, Haley, Gifford, James, Lemelin, Charles-Andre, Lim Soo, Patrick, Perino, Samantha, Moreau, Benoît, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Bilodeau, Mark T, Wooster, Richard

“…Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a 95% mortality rate with no improvement to treatment in decades, and new…”
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Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo by White, Brian H, Whalen, Kerry, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle, Oller, Haley, Lemelin, Charles-Andre, Lim Soo, Patrick, Moreau, Benoît, Perino, Samantha, Quinn, James M, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Wooster, Richard, Bilodeau, Mark T

“…Somatostatin receptor 2 (SSTR2) is frequently overexpressed on several types of solid tumors, including neuroendocrine tumors and small-cell lung cancer…”
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Abstract 39: Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo by White, Brian H., Bazinet, Patrick, Whalen, Kerry, DuPont, Michelle, Quinn, James M., Alargova, Rossitza, Yeung, Tsun Au, Brockman, Adam, Gifford, James, Oller, Haley, Kriksciukaite, Kristina, Lemelin, Charles-Andre, Soo, Patrick Lim, Moreau, Benoit, Perino, Samantha, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Simcox, Mary, Wooster, Richard, Bilodeau, Mark T.

“…Here we describe the discovery and the structure of PEN-221, a somatostatin receptor 2 (SSTR2) targeting peptide conjugated to DM1. PEN-221 is the first…”
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Abstract 3674: Pentarins: Improved tumor targeting through nanoparticle encapsulation of miniaturized biologic drug conjugates by Bilodeau, Mark T., Shinde, Rajesh, White, Brian, Bazinet, Patrick, Whalen, Kerry, Dupont, Michelle, Kriksciukaite, Kristina, Quinn, Jamie, Sweryda-Krawiec, Beata, Alargova, Rossitza, Brockman, Adam, Lim Soo, Patrick, Meetze, Kristan, Moreau, Benoit, Oller, Haley, Ramstack, Mike, Rockwood, Danielle, Singh, Sukhjeet, Yeung, Tsun Au, Kadiyala, Sudha, Dunbar, Craig, Wooster, Richard

“…The specific targeting of cytotoxic drugs to solid tumors has achieved success with the advent of antibody drug conjugates (ADCs). This approach has had…”
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