Search Results - "Au, Vinci"

The million mutation project: a new approach to genetics in Caenorhabditis elegans by Thompson, Owen, Edgley, Mark, Strasbourger, Pnina, Flibotte, Stephane, Ewing, Brent, Adair, Ryan, Au, Vinci, Chaudhry, Iasha, Fernando, Lisa, Hutter, Harald, Kieffer, Armelle, Lau, Joanne, Lee, Norris, Miller, Angela, Raymant, Greta, Shen, Bin, Shendure, Jay, Taylor, Jon, Turner, Emily H, Hillier, LaDeana W, Moerman, Donald G, Waterston, Robert H

“…We have created a library of 2007 mutagenized Caenorhabditis elegans strains, each sequenced to a target depth of 15-fold coverage, to provide the research…”
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Peel-1 negative selection promotes screening-free CRISPR-Cas9 genome editing in Caenorhabditis elegans by McDiarmid, Troy A, Au, Vinci, Moerman, Donald G, Rankin, Catharine H

“…Improved genome engineering methods that enable automation of large and precise edits are essential for systematic investigations of genome function. We…”
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CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans by Au, Vinci, Li-Leger, Erica, Raymant, Greta, Flibotte, Stephane, Chen, George, Martin, Kiana, Fernando, Lisa, Doell, Claudia, Rosell, Federico I, Wang, Su, Edgley, Mark L, Rougvie, Ann E, Hutter, Harald, Moerman, Donald G

“…The Gene Knockout Consortium is tasked with obtaining null mutations in each of the more than 20,000 open reading frames (ORFs) of this organism. To date,…”
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CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance by McDiarmid, Troy A, Au, Vinci, Loewen, Aaron D, Liang, Joseph, Mizumoto, Kota, Moerman, Donald G, Rankin, Catharine H

“…Our ability to sequence genomes has vastly surpassed our ability to interpret the genetic variation we discover. This presents a major challenge in the…”
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Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity by Mathew, Mark D, Mathew, Neal D, Miller, Angela, Simpson, Mike, Au, Vinci, Garland, Stephanie, Gestin, Marie, Edgley, Mark L, Flibotte, Stephane, Balgi, Aruna, Chiang, Jennifer, Giaever, Guri, Dean, Pamela, Tung, Audrey, Roberge, Michel, Roskelley, Calvin, Forge, Tom, Nislow, Corey, Moerman, Donald

“…The lack of new anthelmintic agents is of growing concern because it affects human health and our food supply, as both livestock and plants are affected. Two…”
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Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT) by Timbers, Tiffany A, Garland, Stephanie J, Mohan, Swetha, Flibotte, Stephane, Edgley, Mark, Muncaster, Quintin, Au, Vinci, Li-Leger, Erica, Rosell, Federico I, Cai, Jerry, Rademakers, Suzanne, Jansen, Gert, Moerman, Donald G, Leroux, Michel R

“…Forward genetic screens represent powerful, unbiased approaches to uncover novel components in any biological process. Such screens suffer from a major…”
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UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans by Safdar, Komal, Gu, Anniya, Xu, Xia, Au, Vinci, Taylor, Jon, Flibotte, Stephane, Moerman, Donald G, Maine, Eleanor M

“…Notch-type signaling mediates cell-cell interactions important for animal development. In humans, reduced or inappropriate Notch signaling activity is…”
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The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans by Lissemore, James L, Connors, Elyse, Liu, Ying, Qiao, Li, Yang, Bing, Edgley, Mark L, Flibotte, Stephane, Taylor, Jon, Au, Vinci, Moerman, Donald G, Maine, Eleanor M

“…In a genetic screen to identify genes that promote GLP-1/Notch signaling in germline stem cells, we found a single mutation, , defining a gene called causes…”
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A Strategy To Isolate Modifiers of Caenorhabditis elegans Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2 by Wiesenfahrt, Tobias, Duanmu, Jingjie, Snider, Frances, Moerman, Don, Au, Vinci, Li-Leger, Erica, Flibotte, Stephane, Parker, Dylan M, Marshall, Craig J, Nishimura, Erin Osborne, Mains, Paul E, McGhee, James D

“…The ELT-2 GATA factor normally functions in differentiation of the endoderm, downstream of endoderm specification. We have previously shown that, if ELT-2 is…”
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Multiple UDP glycosyltransferases modulate benzimidazole drug sensitivity in the nematode Caenorhabditis elegans in an additive manner by Sharma, Nidhi, Au, Vinci, Martin, Kiana, Edgley, Mark L., Moerman, Don, Mains, Paul E., Gilleard, John S.

“…[Display omitted] •Multiple ugt genes modulate benzimidazole sensitivity in Caenorhabditis elegans.•Genetic mutations revealed that loss of ugt-9 and ugt-11…”
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Single-cell genomic variation induced by mutational processes in cancer by Funnell, Tyler, O’Flanagan, Ciara H., Williams, Marc J., McPherson, Andrew, McKinney, Steven, Kabeer, Farhia, Lee, Hakwoo, Salehi, Sohrab, Vázquez-García, Ignacio, Shi, Hongyu, Leventhal, Emily, Masud, Tehmina, Eirew, Peter, Yap, Damian, Zhang, Allen W., Lim, Jamie L. P., Wang, Beixi, Brimhall, Jazmine, Biele, Justina, Ting, Jerome, Au, Vinci, Van Vliet, Michael, Liu, Yi Fei, Beatty, Sean, Lai, Daniel, Pham, Jenifer, Grewal, Diljot, Abrams, Douglas, Havasov, Eliyahu, Leung, Samantha, Bojilova, Viktoria, Moore, Richard A., Rusk, Nicole, Uhlitz, Florian, Ceglia, Nicholas, Weiner, Adam C., Zaikova, Elena, Douglas, J. Maxwell, Zamarin, Dmitriy, Weigelt, Britta, Kim, Sarah H., Da Cruz Paula, Arnaud, Reis-Filho, Jorge S., Martin, Spencer D., Li, Yangguang, Xu, Hong, de Algara, Teresa Ruiz, Lee, So Ra, Llanos, Viviana Cerda, Huntsman, David G., McAlpine, Jessica N., Shah, Sohrab P., Aparicio, Samuel

“…How cell-to-cell copy number alterations that underpin genomic instability 1 in human cancers drive genomic and phenotypic variation, and consequently the…”
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ccd-5, a novel cdk-5 binding partner, regulates pioneer axon guidance in the ventral nerve cord of Caenorhabditis elegans by Feresten, Abigail H, Bhat, Jaffar M, Yu, Alex J, Zapf, Richard, Safi, Hamida, Au, Vinci, Flibotte, Stephane, Doell, Claudia, Moerman, Donald G, Hawkins, Nancy, Rankin, Catharine H, Hutter, Harald

“…Abstract During nervous system development, axons navigate complex environments to reach synaptic targets. Early extending axons must interact with guidance…”
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Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints by Flibotte, Stephane, Edgley, Mark, Au, Vinci, Moerman, Donald G

“…We used whole-genome sequencing (WGS) data from a strain homozygous for the reciprocal translocation to identify its breakpoints molecularly. The translocation…”
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MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes by Mok, Calvin A, Au, Vinci, Thompson, Owen A, Edgley, Mark L, Gevirtzman, Louis, Yochem, John, Lowry, Joshua, Memar, Nadin, Wallenfang, Matthew R, Rasoloson, Dominique, Bowerman, Bruce, Schnabel, Ralf, Seydoux, Geraldine, Moerman, Donald G, Waterston, Robert H

“…Mutants remain a powerful means for dissecting gene function in model organisms such as Massively parallel sequencing has simplified the detection of variants…”
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large-scale screening for targeted knockouts in the Caenorhabditis elegans genome

“…The nematode Caenorhabditis elegans is a powerful model system to study contemporary biological problems. This system would be even more useful if we had…”
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Abstract 2182: The evolution of high grade serous ovarian cancer under the pressure of non-cytotoxic and cytotoxic treatment by Kabeer, Farhia, Lam, Goldman, Adam, Naila, Douglas, Maxwell, El-Naggar, Amal, Kalantari, Forouh, Han, Mengke, Au, Vinci, Van Vliet, Michael, Shen, Cindy, Beaty, Sean, Lai, Daniel, Mungall, Andy, Moore, Richard, Aparicio, Sam, Roth, Andrew, Huntsman, David, Drew, Yvette

“…Abstract Introduction: High-grade serous ovarian cancer (HGSOC) is driven by loss of TP53 and genome instability . Despite the recent success of PARP…”
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