Search Results - "Au, Amanda E"

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice by Daglas, Maria, Draxler, Dominik F., Ho, Heidi, McCutcheon, Fiona, Galle, Adam, Au, Amanda E., Larsson, Pia, Gregory, Julia, Alderuccio, Frank, Sashindranath, Maithili, Medcalf, Robert L.

“…Traumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged immune response in the brain may cause neurodegeneration, resulting…”
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Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin by Borg, Rachael J, Samson, Andre L, Au, Amanda E-L, Scholzen, Anja, Fuchsberger, Martina, Kong, Ying Y, Freeman, Roxann, Mifsud, Nicole A, Plebanski, Magdalena, Medcalf, Robert L

“…Removal of dead cells in the absence of concomitant immune stimulation is essential for tissue homeostasis. We recently identified an injury-induced protein…”
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Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3 by Petrie, Emma J., Sandow, Jarrod J., Lehmann, Wil I.L., Liang, Lung-Yu, Coursier, Diane, Young, Samuel N., Kersten, Wilhelmus J.A., Fitzgibbon, Cheree, Samson, André L., Jacobsen, Annette V., Lowes, Kym N., Au, Amanda E., Jousset Sabroux, Hélène, Lalaoui, Najoua, Webb, Andrew I., Lessene, Guillaume, Manning, Gerard, Lucet, Isabelle S., Murphy, James M.

“…Necroptotic cell death has been implicated in many human pathologies and is thought to have evolved as an innate immunity mechanism. The pathway relies on two…”
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Regulation of platelet membrane protein shedding in health and disease by Au, Amanda E., Josefsson, Emma C.

“…Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein…”
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The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL by Jacobsen, Annette V., Pierotti, Catia L., Lowes, Kym N., Au, Amanda E., Zhang, Ying, Etemadi, Nima, Fitzgibbon, Cheree, Kersten, Wilhelmus J. A., Samson, André L., van Delft, Mark F., Huang, David C. S., Sabroux, Hélène Jousset, Lessene, Guillaume, Silke, John, Murphy, James M.

“…Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed lineage kinase domain-like (MLKL)…”
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Design and characterization of a heterobifunctional degrader of KEAP1 by Chen, Hao, Nguyen, Nghi H., Magtoto, Charlene M., Cobbold, Simon A., Bidgood, Grace M., Meza Guzman, Lizeth G., Richardson, Lachlan W., Corbin, Jason, Au, Amanda E., Lechtenberg, Bernhard C., Feltham, Rebecca, Sutherland, Kate D., Grohmann, Christoph, Nicholson, Sandra E., Sleebs, Brad E.

“…The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway senses reactive oxygen species and…”
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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors by Calleja, Dale J, Kuchel, Nathan, Lu, Bernadine G C, Birkinshaw, Richard W, Klemm, Theresa, Doerflinger, Marcel, Cooney, James P, Mackiewicz, Liana, Au, Amanda E, Yap, Yu Q, Blackmore, Timothy R, Katneni, Kasiram, Crighton, Elly, Newman, Janet, Jarman, Kate E, Call, Melissa J, Lechtenberg, Bernhard C, Czabotar, Peter E, Pellegrini, Marc, Charman, Susan A, Lowes, Kym N, Mitchell, Jeffrey P, Nachbur, Ueli, Lessene, Guillaume, Komander, David

“…The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients…”
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Nucleocytoplasmic Coagulation: An Injury-Induced Aggregation Event that Disulfide Crosslinks Proteins and Facilitates Their Removal by Plasmin by Samson, Andre L., Knaupp, Anja S., Sashindranath, Maithili, Borg, Rachael J., Au, Amanda E.-L., Cops, Elisa J., Saunders, Helen M., Cody, Stephen H., McLean, Catriona A., Nowell, Cameron J., Hughes, Victoria A., Bottomley, Stephen P., Medcalf, Robert L.

“…Cellular injury causes a myriad of processes that affect proteostasis. We describe nucleocytoplasmic coagulation (NCC), an intracellular disulfide-dependent…”
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Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells by Samson, Andre L., Ho, Bosco, Au, Amanda E., Schoenwaelder, Simone M., Smyth, Mark J., Bottomley, Stephen P., Kleifeld, Oded, Medcalf, Robert L.

“…Amyloidogenic protein aggregation impairs cell function and is a hallmark of many chronic degenerative disorders. Protein aggregation is also a major event…”
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Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis by Draxler, Dominik F., Daglas, Maria, Fernando, Anushka, Hanafi, Gryselda, McCutcheon, Fiona, Ho, Heidi, Galle, Adam, Gregory, Julia, Larsson, Pia, Keragala, Charithani, Wright, David K., Tavancheh, Elnaz, Au, Amanda E., Niego, Be'eri, Wilson, Kirsty, Plebanski, Magdalena, Sashindranath, Maithili, Medcalf, Robert L.

“…Background Traumatic brain injury (TBI) is known to promote immunosuppression, making patients more susceptible to infection, yet potentially exerting…”
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Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion by Pleines, Irina, Lebois, Marion, Gangatirkar, Pradnya, Au, Amanda E., Lane, Rachael M., Henley, Katya J., Kauppi, Maria, Corbin, Jason, Cannon, Ping, Bernardini, Jonathan, Alwis, Imala, Jarman, Kate E., Ellis, Sarah, Metcalf, Donald, Jackson, Shaun P., Schoenwaelder, Simone M., Kile, Benjamin T., Josefsson, Emma C.

“…The circulating life span of blood platelets is regulated by the prosurvival protein BCL-XL. It restrains the activity of BAK and BAX, the essential prodeath…”
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Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin by Niego, Be'eri, Lee, Natasha, Larsson, Pia, De Silva, T Michael, Au, Amanda E-Ling, McCutcheon, Fiona, Medcalf, Robert L

“…Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced…”
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Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels by Au, Amanda E., Corbin, Jason, Lebois, Marion, Gangatirkar, Pradnya, Yassinson, Fatme, Hyslop, Stephanie R., Cannon, Ping, Mason, Kylie D., Li-Wai-Suen, Connie S. N., Garnham, Alexandra L., Moujalled, Diane, Cimmino, Luisa, Alexander, Warren S., Josefsson, Emma C.

“…•Increased levels of interleukin 1 were found in the bone marrow fluid of TpoTg mice, whereas levels were lowered in Mpl−/− mice.•A proinflammatory…”
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Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling by Au, Amanda E., Lebois, Marion, Sim, Starling A., Cannon, Ping, Corbin, Jason, Gangatirkar, Pradnya, Hyland, Craig D., Moujalled, Diane, Rutgersson, Angelika, Yassinson, Fatme, Kile, Benjamin T., Mason, Kylie D., Ng, Ashley P., Alexander, Warren S., Josefsson, Emma C.

“…Thrombopoietin (TPO) is the master cytokine regulator of megakaryopoiesis. In addition to regulation of megakaryocyte and platelet number, TPO is important for…”
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Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis by Draxler, Dominik F., Daglas, Maria, Fernando, Anushka, Hanafi, Gryselda, McCutcheon, Fiona, Ho, Heidi, Galle, Adam, Gregory, Julia, Larsson, Pia, Keragala, Charithani, Wright, David K., Tavancheh, Elnaz, Au, Amanda E., Niego, Be'eri, Wilson, Kirsty, Plebanski, Magdalena, Sashindranath, Maithili, Medcalf, Robert L.

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Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 by Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David

“…The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the…”
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Selective inhibition of brain endothelial Rhokinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin by Niego, B., Lee, N., Larsson, Pia, de Silva, T. M., Au, A. E. L., McCutcheon, F., Medcalf, R. L.

“…Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced…”
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Extended Platelet In Vivo Survival Results in Exhausted Platelets by Pleines, Irina, Lebois, Marion, Au, Amanda E.-L., Lane, Rachael M., Henley, Katya J., Corbin, Jason, Cannon, Ping, Jarman, Kate E, Ellis, Sarah, Jackson, Shaun P, Schoenwaelder, Simone M., Kile, Benjamin T., Josefsson, Emma C.

“…Platelet lifespan is limited to 10 days in humans and 5 days in mice. The intrinsic apoptosis pathway regulates the survival of platelets, where the…”
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Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin: e0131216 by Borg, Rachael J, Samson, Andre L, Au, Amanda E-L, Scholzen, Anja, Fuchsberger, Martina, Kong, Ying Y, Freeman, Roxann, Mifsud, Nicole A, Plebanski, Magdalena, Medcalf, Robert L

“…Removal of dead cells in the absence of concomitant immune stimulation is essential for tissue homeostasis. We recently identified an injury-induced protein…”
Get full text