Search Results - "Atzrodt, Jens"

C−H Functionalisation for Hydrogen Isotope Exchange by Atzrodt, Jens, Derdau, Volker, Kerr, William J., Reid, Marc

“…The various applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demand a range of methods for their installation…”
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Renaissance of H/D Exchange by Atzrodt, Jens, Derdau, Volker, Fey, Thorsten, Zimmermann, Jochen

“…The increasing demand for stable isotopically labeled compounds has led to an increased interest in H/D-exchange reactions at carbon centers. Today…”
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Highly Selective Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides by Valero, Mégane, Weck, Remo, Güssregen, Stefan, Atzrodt, Jens, Derdau, Volker

“…For the first time, we describe highly selective homogeneous iridium‐catalyzed hydrogen isotope exchange (HIE) of unactivated C(sp3) centers in aliphatic…”
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NHC‐Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines by Valero, Mégane, Bouzouita, Donia, Palazzolo, Alberto, Atzrodt, Jens, Dugave, Christophe, Tricard, Simon, Feuillastre, Sophie, Pieters, Grégory, Chaudret, Bruno, Derdau, Volker

“…The preparation of N‐heterocyclic carbene‐stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These…”
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Cabazitaxel is more active than first-generation taxanes in ABCB1(+) cell lines due to its reduced affinity for P-glycoprotein by Duran, George E., Derdau, Volker, Weitz, Dietmar, Philippe, Nicolas, Blankenstein, Jörg, Atzrodt, Jens, Sémiond, Dorothée, Gianolio, Diego A., Macé, Sandrine, Sikic, Branimir I.

“…Purpose The primary aim of this study was to determine cabazitaxel’s affinity for the ABCB1 /P-glycoprotein (P-gp) transporter compared to first-generation…”
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Hydrogen–Deuterium Exchange Reactions of Aromatic Compounds and Heterocycles by NaBD4‐Activated Rhodium, Platinum and Palladium Catalysts by Derdau, Volker, Atzrodt, Jens, Zimmermann, Jochen, Kroll, Carsten, Brückner, Francois

“…Conventional thermal and microwave conditions were compared for hydrogen–deuterium (H/D) exchange reactions of aminobenzoic acids catalysed by NaBD4‐activated…”
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Highly Selective Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides by Valero, Mégane, Weck, Remo, Güssregen, Stefan, Atzrodt, Jens, Derdau, Volker

“…For the first time, we describe highly selective homogeneous iridium‐catalyzed hydrogen isotope exchange (HIE) of unactivated C(sp3) centers in aliphatic…”
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The synthesis of selected phase II metabolites – Ο-glucuronides and sulfates of drug development candidates by Atzrodt, Jens, Derdau, Volker, Holla, Wolfgang, Sandvoss, Martin

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Deuterium‐ and Tritium‐Labelled Compounds: Applications in the Life Sciences by Atzrodt, Jens, Derdau, Volker, Kerr, William J., Reid, Marc

“…Hydrogen isotopes are unique tools for identifying and understanding biological and chemical processes. Hydrogen isotope labelling allows for the traceless and…”
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Pd- and Pt-catalyzed H/D exchange methods and their application for internal MS standard preparation from a Sanofi-Aventis perspective by Atzrodt, Jens, Derdau, Volker

“…This review addresses method developments both homogeneous and heterogeneous Pd‐ and Pt‐catalyzed exchange, including catalyst activation principles and recent…”
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Deuterium‐ und tritiummarkierte Verbindungen: Anwendungen in den modernen Biowissenschaften by Atzrodt, Jens, Derdau, Volker, Kerr, William J., Reid, Marc

“…Wasserstoffisotope sind einzigartige Werkzeuge zur Identifizierung und Erforschung biologischer oder chemischer Vorgänge. Wasserstoffisotopenmarkierungen…”
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Iridium-Catalyzed Csp3–H Activation for Mild and Selective Hydrogen Isotope Exchange by Kerr, William J, Mudd, Richard J, Reid, Marc, Atzrodt, Jens, Derdau, Volker

“…The increasing demand for isotopically labeled compounds has provided an appreciable impetus for the development of improved methods for the late-stage…”
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Methoden der C‐H‐Funktionalisierung für den Wasserstoffisotopenaustausch by Atzrodt, Jens, Derdau, Volker, Kerr, William J., Reid, Marc

“…Abstract Die vielfältigen Anwendungen der Wasserstoffisotope (Deuterium, D, und Tritium, T) in den physikalischen und Biowissenschaften erfordern…”
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Hydrogen‐Isotope Exchange (HIE) Reactions of Secondary and Tertiary Sulfonamides and Sulfonylureas with Iridium(I) Catalysts by Burhop, Annina, Weck, Remo, Atzrodt, Jens, Derdau, Volker

“…For the first time we report the optimized hydrogen‐isotope exchange (HIE) conditions for the selective aromatic deuteriation of various sulfonylureas and…”
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Expanded applicability of iridium(I) NHC/phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles by Atzrodt, Jens, Derdau, Volker, Kerr, William J., Reid, Marc, Rojahn, Patrick, Weck, Remo

“…An assessment of emerging C–H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope,…”
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Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Phenylacetic Acid Esters and Amides by Valero, Mégane, Becker, Daniel, Jess, Kristof, Weck, Remo, Atzrodt, Jens, Bannenberg, Thomas, Derdau, Volker, Tamm, Matthias

“…For the first time, a catalytic protocol for a highly selective hydrogen isotope exchange (HIE) of phenylacetic acid esters and amides under very mild reaction…”
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Burgess iridium(I)‐catalyst for selective hydrogen isotope exchange by Burhop, Annina, Prohaska, Raphail, Weck, Remo, Atzrodt, Jens, Derdau, Volker

“…We have evaluated the commercially available Burgess catalyst in hydrogen isotope exchange reactions with several substrates bearing different directing group…”
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Ruthenium-Catalyzed Selective α,β-Deuteration of Bioactive Amines by Neubert, Lorenz, Michalik, Dirk, Bähn, Sebastian, Imm, Sebastian, Neumann, Helfried, Atzrodt, Jens, Derdau, Volker, Holla, Wolfgang, Beller, Matthias

“…A novel and convenient protocol for the catalytic hydrogen–deuterium exchange of biologically active tertiary amines utilizing the borrowing hydrogen…”
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Hydrogen Isotope Exchange with Iridium(I) Complexes Supported by Phosphine‐Imidazolin‐2‐imine P,N Ligands by Jess, Kristof, Derdau, Volker, Weck, Remo, Atzrodt, Jens, Freytag, Matthias, Jones, Peter G., Tamm, Matthias

“…Phenylene‐bridged hybrid phosphine‐imidazolin‐2‐imine RP,NR′ ligands (R=Ph, Cy, i‐Pr, t‐Bu; R′=Me, i‐Pr) were prepared from 1,2‐dibromobenzene by…”
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Evaluation of a P,N‐ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds by Valero, Mégane, Burhop, Annina, Jess, Kristof, Weck, Remo, Tamm, Matthias, Atzrodt, Jens, Derdau, Volker

“…We have developed a novel and efficient iridium‐catalyzed hydrogen isotope exchange reaction method with secondary and tertiary sulfonamides at ambient…”
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