Search Results - "Atwood, CS"

Most Reported Genetic Associations With General Intelligence Are Probably False Positives by Chabris, Christopher F., Hebert, Benjamin M., Benjamin, Daniel J., Beauchamp, Jonathan, Cesarini, David, van der Loos, Matthijs, Johannesson, Magnus, Magnusson, Patrik K. E., Lichtenstein, Paul, Atwood, Craig S., Freese, Jeremy, Hauser, Taissa S., Hauser, Robert M., Christakis, Nicholas, Laibson, David

“…General intelligence (g) and virtually all other behavioral traits are heritable. Associations between g and specific single-nucleotide polymorphisms (SNPs) in…”
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Progesterone induces side-branching of the ductal epithelium in the mammary glands of peripubertal mice by Atwood, CS, Hovey, RC, Glover, JP, Chepko, G, Ginsburg, E, Robison, WG, Vonderhaar, BK

“…Development of the functional secretory epithelium in the mammary gland of the female mouse requires the elongation of the anlage through the mammary fat pad…”
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Mounting evidence for the involvement of zinc and copper in Alzheimer's disease by Moir, R D, Atwood, C S, Huang, X, Tanzi, R E, Bush, A I

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Metal Binding and Oxidation of Amyloid-β within Isolated Senile Plaque Cores:  Raman Microscopic Evidence by Dong, Jian, Atwood, Craig S, Anderson, Vernon E, Siedlak, Sandra L, Smith, Mark A, Perry, George, Carey, Paul R

“…Alzheimer's disease (AD) is characterized by the deposition of amyloid plaques in the parenchyma and vasculature of the brain. Although previous analytical…”
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Leuprolide acetate: a drug of diverse clinical applications by Wilson, Andrea C, Meethal, Sivan Vadakkadath, Bowen, Richard L, Atwood, Craig S

“…Leuprolide acetate is a synthetic nonapeptide that is a potent gonadotropin-releasing hormone receptor (GnRHR) agonist used for diverse clinical applications,…”
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The role of hypothalamic-pituitary-gonadal hormones in the normal structure and functioning of the brain by Vadakkadath Meethal, S, Atwood, C S

“…Receptors for hormones of the hypothalamic-pituitary-gonadal (HPG) axis that regulate reproductive function are expressed throughout the brain, and in…”
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Oxidative Damage Is the Earliest Event in Alzheimer Disease by NUNOMURA, AKIHIKO, PERRY, GEORGE, ALIEV, GJUMRAKCH, HIRAI, KEISUKE, TAKEDA, ATSUSHI, BALRAJ, ELIZABETH K, JONES, PAUL K, GHANBARI, HOSSEIN, WATAYA, TAKAFUMI, SHIMOHAMA, SHUN, CHIBA, SHIGERU, ATWOOD, CRAIG S, PETERSEN, ROBERT B, SMITH, MARK A

“…Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid,…”
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Characterization of Copper Interactions with Alzheimer Amyloid beta Peptides. Identification of an Attomolar-Affinity Copper Binding Site on Amyloid beta 1-42 by Atwood, C S, Scarpa, R C, Huang, Xudong, Moir, R D, Jones, W D, Fairlie, D P, Tanzi, R E, Bush, AI

“…Cu and Zn have been shown to accumulate in the brains of Alzheimer's disease patients. We have previously reported that Cu super(2+) and Zn super(2+) bind…”
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The Promises and Pitfalls of Genoeconomics by Benjamin, Daniel J., Cesarini, David, Chabris, Christopher F., Glaeser, Edward L., Laibson, David I., Guðnason, Vilmundur, Harris, Tamara B., Launer, Lenore J., Purcell, Shaun, Smith, Albert Vernon, Johannesson, Magnus, Magnusson, Patrik K.E., Beauchamp, Jonathan P., Christakis, Nicholas A., Atwood, Craig S., Hebert, Benjamin, Freese, Jeremy, Hauser, Robert M., Hauser, Taissa S., Grankvist, Alexander, Hultman, Christina M., Lichtenstein, Paul

“…This article reviews existing research at the intersection of genetics and economics, presents some new findings that illustrate the state of genoeconomics…”
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Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice by Cherny, Robert A, Atwood, Craig S, Xilinas, Michel E, Gray, Danielle N, Jones, Walton D, McLean, Catriona A, Barnham, Kevin J, Volitakis, Irene, Fraser, Fiona W, Kim, Young-Seon, Huang, Xudong, Goldstein, Lee E, Moir, Robert D, Lim, James T, Beyreuther, Konrad, Zheng, Hui, Tanzi, Rudolph E, Masters, Colin L, Bush, Ashley I

“…Inhibition of neocortical β-amyloid (Aβ) accumulation may be essential in an effective therapeutic intervention for Alzheimer's disease (AD). Cu and Zn are…”
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Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β by Atwood, Craig S, Perry, George, Zeng, Hong, Kato, Yoji, Jones, Walton D, Ling, Ke-Qing, Huang, Xudong, Moir, Robert D, Wang, Dandan, Sayre, Lawrence M, Smith, Mark A, Chen, Shu G, Bush, Ashley I

“…We have previously reported that amyloid Aβ, the major component of senile plaques in Alzheimer's disease (AD), binds Cu with high affinity via histidine and…”
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Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones by Bowen, Richard L, Atwood, Craig S

“…A mechanistic understanding of aging has yet to be described; this paper puts forth a new theory that has the potential to explain aging in all sexually…”
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Mitochondrial Abnormalities in Alzheimer's Disease by Hirai, Keisuke, Aliev, Gjumrakch, Nunomura, Akihiko, Fujioka, Hisashi, Russell, Robert L, Atwood, Craig S, Johnson, Anne B, Kress, Yvonne, Vinters, Harry V, Tabaton, Massimo, Shimohama, Shun, Cash, Adam D, Siedlak, Sandra L, Harris, Peggy L. R, Jones, Paul K, Petersen, Robert B, Perry, George, Smith, Mark A

“…The finding that oxidative damage, including that to nucleic acids, in Alzheimer's disease is primarily limited to the cytoplasm of susceptible neuronal…”
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Novel d-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases by Cui, Zhengrong, Lockman, Paul R., Atwood, Craig S., Hsu, Cheng-Hsuan, Gupte, Anshul, Allen, David D., Mumper, Russell J.

“…Metal ions accumulate in the brain with aging and in several neurodegenerative diseases. Aside from the copper storage disease, Wilson's disease, recent…”
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Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases? by Perry, George, Nunomura, Akihiko, Hirai, Keisuke, Zhu, Xiongwei, Prez, Mar, Avila, Jess, Castellani, Rudolph J, Atwood, Craig S, Aliev, Gjumrakch, Sayre, Lawrence M, Takeda, Atsushi, Smith, Mark A

“…In less than a decade, beginning with the demonstration by Floyd, Stadtman, Markesbery et al. [1] of increased reactive carbonyls in the brains of patients…”
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Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition by Bowen, Richard L, Verdile, Giuseppe, Liu, Tianbing, Parlow, Albert F, Perry, George, Smith, Mark A, Martins, Ralph N, Atwood, Craig S

“…Hormonal changes associated with the dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis following menopause/andropause have been implicated in the…”
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Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis by Atwood, Craig S., Moir, Robert D., Huang, Xudong, Scarpa, Richard C., Bacarra, N. Michael E., Romano, Donna M., Hartshorn, Mariana A., Tanzi, Rudolph E., Bush, Ashley I.

“…The cortical deposition of Aβ is an event that occurs in Alzheimer's disease, Down's syndrome, head injury, and normal aging. Previously, in appraising the…”
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Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc by Cuajungco, Math P., Goldstein, Lee E., Nunomura, Akihiko, Smith, Mark A., Lim, James T., Atwood, Craig S., Huang, Xudong, Farrag, Yasser W., Perry, George, Bush, Ashley I.

“…Aβ binds Zn2+, Cu2+, and Fe3+in vitro, and these metals are markedly elevated in the neocortex and especially enriched in amyloid plaque deposits of…”
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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction by Huang, Xudong, Atwood, Craig S, Hartshorn, Mariana A, Multhaup, Gerd, Goldstein, Lee E, Scarpa, Richard C, Cuajungco, Math P, Gray, Danielle N, Lim, James, Moir, Robert D, Tanzi, Rudolph E, Bush, Ashley I

“…Oxidative stress markers characterize the neuropathology both of Alzheimer's disease and of amyloid-bearing transgenic mice. The neurotoxicity of amyloid Aβ…”
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Cu(II) Potentiation of Alzheimer A beta Neurotoxicity: CORRELATION WITH CELL-FREE HYDROGEN PEROXIDE PRODUCTION AND METAL REDUCTION by Huang, X, Atwood, C S, Hartshorn, MA, Tyndall, JDA, Hanson, G R, Stokes, K C, Leopold, M, Multhaup, G, Goldstein, LE, Scarpa, R C, Saunders, A J, Lim, J, Moir, R D, Glabe, C, Bowden, E F, Masters, CL, Fairlie, D P, Tanzi, R E, Bush, AI

“…Oxidative stress markers as well as high concentrations of copper are found in the vicinity of A beta amyloid deposits in Alzheimer's disease. The…”
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