Search Results - "Atwal, S. K."

A PHASE 1 STUDY EVALUATING PRT2527, A POTENT AND HIGHLY SELECTIVE CDK9 INHIBITOR, IN PATIENTS WITH SELECT RELAPSED/REFRACTORY B‐CELL MALIGNANCIES by Cheson, B. D., Morschhauser, F., Assouline, S. E., Michallet, A., Tani, M., Paris, G., Sun, W., Atwal, S. K., Hong, W., Sarkozy, C.

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PHASE 1 STUDY OF PRT1419 (MCL1 INHIBITOR) AS MONOTHERAPY OR IN COMBINATION WITH AZACITIDINE OR VENETOCLAX IN PATIENTS WITH RELAPSED/REFRACTORY MYELOID OR B‐CELL MALIGNANCIES by Zuniga, R. R., Nair, S., Keiffer, G., Ravandi‐Kashani, F., Goldberg, A. D., Traer, E., Frenzel, L. P., Röllig, C., Savickas, G., Sun, W., Atwal, S. K., Hong, W., Assouline, S. E.

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Cardioprotective effects of the potassium channel opener cromakalim: stereoselectivity and effects on myocardial adenine nucleotides by Grover, G J, Newburger, J, Sleph, P G, Dzwonczyk, S, Taylor, S C, Ahmed, S Z, Atwal, K S

“…We determined if the cardioprotective effects of the potassium channel opener cromakalim are stereoselective and if it can preserve adenine nucleotides in…”
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Nucleotide regulation and characteristics of potassium channel opener binding to skeletal muscle membranes by Dickinson, K E, Bryson, C C, Cohen, R B, Rogers, L, Green, D W, Atwal, K S

“…[3H]P1075 binding to membrane preparations of rabbit skeletal muscle were observed in the presence of nucleotide triphosphates or diphosphates but not AMP,…”
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Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1 by Ahmad, Saleem, Doweyko, Lidia M, Dugar, Sundeep, Grazier, Nyeemah, Ngu, Khehyong, Wu, Shung C, Yost, Kenneth J, Chen, Bang-Chi, Gougoutas, Jack Z, DiMarco, John D, Lan, Shih-Jung, Gavin, Brian J, Chen, Alice Y, Dorso, Charles R, Serafino, Randy, Kirby, Mark, Atwal, Karnail S

“…A novel series of arylcyclopropanecarboxyl guanidines was synthesized and evaluated for activity against the sodium hydrogen exchanger isoform-1 (NHE-1). In…”
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Modulation of potassium channels by organic molecules by Atwal, K S

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Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines by Atwal, Karnail S, Rovnyak, George C, Schwartz, Joseph, Moreland, Suzanne, Hedberg, Anders, Gougoutas, Jack Z, Malley, Mary F, Floyd, David M

“…2-Heterosubstituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecar box ylic acid esters 8, which lack the potential CS symmetry of dihydropyridine calcium channel…”
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Binding of ATP-Sensitive Potassium Channel (KATP) Openers to Cardiac Membranes:  Correlation of Binding Affinities with Cardioprotective and Smooth Muscle Relaxing Potencies by Atwal, Karnail S, Grover, Gary J, Lodge, Nicholas J, Normandin, Diane E, Traeger, Sarah C, Sleph, Paul G, Cohen, Robert B, Bryson, Catherine C, Dickinson, Keneth E. J

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Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448 by Grover, G J, McCullough, J R, D'Alonzo, A J, Sargent, C A, Atwal, K S

“…ATP-sensitive potassium channel (KATP) openers have direct protective effects on ischemic myocardium that are independent of vasorelaxation. Because reference…”
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Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KA TP) Openers. 6. Effect of Modifications at C6 of Benzopyranyl Cyanoguanidines by Ding, Charles Z, Rovnyak, George C, Misra, Raj N, Grover, Gary J, Miller, Arthur V, Ahmed, Syed Z, Kelly, Yolanda, Normandin, Diane E, Sleph, Paul G, Atwal, Karnail S

“…The effect on potency and selectivity of modifications at the C6 position of the cardioprotective KATP opener BMS-180448 (2) is described. Structure−activity…”
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Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters by Atwal, Karnail S, Bergey, James L, Hedberg, Anders, Moreland, Suzanne

“…2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters, based on the structures of dihydropyridines and diltiazem, were synthesized from…”
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Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents by Rovnyak, G C, Atwal, K S, Hedberg, A, Kimball, S D, Moreland, S, Gougoutas, J Z, O'Reilly, B C, Schwartz, J, Malley, M F

“…We have examined a series of novel dihydropyrimidine calcium channel blockers that contain a basic group attached to either C5 or N3 of the heterocyclic ring…”
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Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents by Atwal, Karnail S, Swanson, Brian N, Unger, Steven E, Floyd, David M, Moreland, Suzanne, Hedberg, Anders, O'Reilly, Brian C

“…In order to explain the potent antihypertensive activity of the modestly active (IC50 = 3.2 microM) dihydropyrimidine calcium channel blocker 5, we carried out…”
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Dihydropyrimidine angiotensin II receptor antagonists by Atwal, Karnail S, Ahmed, Syed Z, Bird, J. Eileen, Delaney, Carol L, Dickinson, Kenneth E. J, Ferrara, Francis N, Hedberg, Anders, Miller, Arthur V, Moreland, Suzanne

“…The discovery of the nonpeptide angiotensin II (AII) receptor antagonist losartan, previously called DuP 753, has stimulated considerable interest in the…”
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Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines by Atwal, K S, Rovnyak, G C, Kimball, S D, Floyd, D M, Moreland, S, Swanson, B N, Gougoutas, J Z, Schwartz, J, Smillie, K M, Malley, M F

“…To enhance the intrinsic potency of dihydropyrimidine calcium channel blockers, we have modified the structure of previously described…”
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Cardioselective anti-ischemic ATP-sensitive potassium channel openers by Atwal, Karnail S, Grover, Gary J, Ahmed, Syed Z, Ferrara, Francis N, Harper, Timothy W, Kim, Kyoung S, Sleph, Paul G, Dzwonczyk, Steven, Russell, Anita D

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Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects by Atwal, Karnail S, O'Reilly, Brian C, Ruby, Eric P, Turk, Chester F, Aberg, Gunnar, Asaad, Magdi M, Bergey, James L, Moreland, Suzanne, Powell, James R

“…Substituted 1,2,3,4-tetrahydroaminonaphthols were found to be calcium channel blockers with antihypertensive properties. These compounds also possessed…”
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Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KATP) Openers. 5. Identification of 4-(N-Aryl)-Substituted Benzopyran Derivatives with High Selectivity by Rovnyak, George C, Ahmed, Syed Z, Ding, Charles Z, Dzwonczyk, Steven, Ferrara, Francis N, Humphreys, W. Griffith, Grover, Gary J, Santafianos, Dinos, Atwal, Karnail S, Baird, Anne J, McLaughlin, Lee G, Normandin, Diane E, Sleph, Paul G, Traeger, Sarah C

“…This paper describes our studies aimed at the discovery of structurally distinct analogs of the cardioprotective KATP opener BMS-180448 (2) with improved…”
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Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 2. Structure-Activity Studies on Benzopyranylcyanoguanidines; Modification of the Benzopyran Ring by Atwal, Karnail S, Grover, Gary J, Ferrara, Francis N, Ahmed, Syed Z, Sleph, Paul G, Dzwonczyk, Steven, Normandin, Diane E

“…The ATP-sensitive potassium channel (KATP) openers are of considerable interest as myocardial protecting agents. However, there exists a narrow window of…”
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Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers by Atwal, K S

“…KATP openers are recognized as having a therapeutic potential for the treatment of various cardiovascular and noncardiovascular diseases. However, the…”
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