Search Results - "Attur, Mukundan G."

F-spondin deficient mice have a high bone mass phenotype by Palmer, Glyn D, Attur, Mukundan G, Yang, Qing, Liu, James, Moon, Paxton, Beier, Frank, Abramson, Steven B

“…F-spondin is a pericellular matrix protein upregulated in developing growth plate cartilage and articular cartilage during osteoarthritis. To address its…”
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Transcriptional Repression of Matrix Metalloproteinase Gene Expression by the Orphan Nuclear Receptor NURR1 in Cartilage by Mix, Kimberlee S., Attur, Mukundan G., Al-Mussawir, Hayf, Abramson, Steven B., Brinckerhoff, Constance E., Murphy, Evelyn P.

“…The NR4A orphan receptors (Nur77, NURR1, and NOR-1) are emerging as key regulators of cytokine and growth factor action in chronic inflammatory diseases. In…”
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A Novel Mechanism of Action of Tetracyclines: Effects on Nitric Oxide Synthases by Amin, Ashok R., Attur, Mukundan G., Thakker, Geeta D., Patel, Prakash D., Vyas, Pranav R., Patel, Rajesh N., Patel, Indravadan R., Abramson, Steven B.

“…Tetracyclines have recently been shown to have ``chondroprotective'' effects in inflammatory arthritides in animal models. Since nitric oxide (NO) is…”
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F-spondin regulates chondrocyte terminal differentiation and endochondral bone formation by Palmer, Glyn D., Piton, Alejandro H., Thant, Lwin Mon, Oliveira, Serafim M., D'Angelo, Marina, Attur, Mukundan G., Abramson, Steven B., Teixeira, Cristina C.

“…This study examines the role of F‐spondin, an extracellular matrix protein of osteoarthritic cartilage, during chondrocyte maturation in embryonic growth plate…”
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Toward understanding the role of cartilage particulates in synovial inflammation by Silverstein, Amy M, Stefani, Robert M, Sobczak, Evie, Tong, Eric L, Attur, Mukundan G, Shah, Roshan P, Bulinski, J. Chloe, Ateshian, Gerard A, Hung, Clark T

“…Abstract Objective Arthroscopy with lavage and synovectomy can remove tissue debris from the joint space and the synovial lining to provide pain relief to…”
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Regulation of Cytosolic COX-2 and Prostaglandin E2 Production by Nitric Oxide in Activated Murine Macrophages by Patel, Rajesh, Attur, Mukundan G, Dave, Mandar, Abramson, Steven B, Amin, Ashok R

“…Murine macrophages (RAW 264.7) when stimulated with LPS show 90% distribution of cyclooxygenase-2 (COX-2) in the nuclear fraction and approximately 10% in the…”
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Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription by Mix, Kimberlee S., McMahon, Kevin, McMorrow, Jason P., Walkenhorst, Dana E., Smyth, Aisling M., Petrella, Brenda L., Gogarty, Martina, Fearon, Ursula, Veale, Douglas, Attur, Mukundan G., Abramson, Steven B., Murphy, Evelyn P.

“…Objective To address the role of the nuclear receptor 4A (NR4A) family of orphan nuclear receptors in synoviocyte transformation, hyperplasia, and regulation…”
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F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-β activation by Attur, Mukundan G, Palmer, Glyn D, Al-Mussawir, Hayf E, Dave, Mandar, Teixeira, Cristina C, Rifkin, Daniel B, Appleton, C. Thomas G, Beier, Frank, Abramson, Steven B

“…In osteoarthritis (OA) articular chondrocytes undergo phenotypic changes culminating in the progressive loss of cartilage from the joint surface. The molecular…”
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A Novel Mechanism of Action of Chemically Modified Tetracyclines: Inhibition of COX-2-Mediated Prostaglandin E2 Production by Patel, Rajesh N, Attur, Mukundan G, Dave, Mandar N, Patel, Indravadan V, Stuchin, Steven A, Abramson, Steven B, Amin, Ashok R

“…Tetracyclines (doxycycline and minocycline) inhibit inducible NO synthase expression and augment cyclooxygenase (COX)-2 expression and PGE2 production. In…”
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Tetracycline Up-Regulates COX-2 Expression and Prostaglandin E2 Production Independent of Its Effect on Nitric Oxide by Attur, Mukundan G, Patel, Rajesh N, Patel, Prakash D, Abramson, Steven B, Amin, Ashok R

“…Tetracyclines (doxycycline and minocycline) augmented (one- to twofold) the PGE2 production in human osteoarthritis-affected cartilage (in the presence or…”
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Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines by Amin, Ashok R, Patel, Rajesh N, Thakker, Geeta D, Lowenstein, Charles J, Attur, Mukundan G, Abramson, Steven B

“…Chemically modified tetracyclines [CMT-3 (IC 50 ∼6–13 μM = ∼2.5–5 μg/ml) and CMT-8 (IC 50 ∼26 μM = 10 μg/ml), but not CMT-1, -2 or -5], which lack…”
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Reversal of Autocrine and Paracrine Effects of Interleukin 1 (IL-1) in Human Arthritis by Type II IL-1 Decoy Receptor by Attur, Mukundan G., Dave, Mandar, Cipolletta, Christine, Kang, Pil, Goldring, Mary B., Patel, Indravadan R., Abramson, Steven B., Amin, Ashok R.

“…Interleukin 1 (IL-1), produced by both synovial cells and chondrocytes, plays a pivotal role in the pathogenesis of cartilage destruction in osteoarthritis…”
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Functional genomics approaches in arthritis by Attur, Mukundan G, Dave, Mandar N, Amin, Ashok R

“…The post-genomic era of functional genomics and target validation will allow us to narrow the bridge between clinically correlative data and causative data for…”
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Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage by Attur, M G, Patel, R N, Abramson, S B, Amin, A R

“…To examine the effect of human interleukin-17 (IL-17) on nitric oxide (NO) production in human osteoarthritis (OA) cartilage under ex vivo conditions. OA…”
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Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention by Attur, M G, Dave, M, Cipolletta, C, Kang, P, Goldring, M B, Patel, I R, Abramson, S B, Amin, A R

“…Interleukin 1 (IL-1), produced by both synovial cells and chondrocytes, plays a pivotal role in the pathogenesis of cartilage destruction in osteoarthritis…”
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Osteopontin: An intrinsic inhibitor of inflammation in cartilage by Attur, Mukundan G., Dave, Mandar N., Stuchin, Steven, Kowalski, Aaron J., Steiner, German, Abramson, Steven B., Denhardt, David T., Amin, Ashok R.

“…Objective To identify extracellular and intraarticular matrix components that are differentially expressed in normal and osteoarthritis (OA)–affected cartilage…”
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Functional Genomic Analysis of Type II IL-1β Decoy Receptor: Potential for Gene Therapy in Human Arthritis and Inflammation by Attur, Mukundan G., Dave, Mandar N., Leung, Mary Y., Cipolletta, Christine, Meseck, Marcia, Woo, Savio L. C., Amin, Ashok R.

“…Abstract Gene expression arrays show that human epithelial cells and human arthritis-affected cartilage lack detectable amounts of mRNA for IL-1 antagonizing…”
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TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha by Patel, I R, Attur, M G, Patel, R N, Stuchin, S A, Abagyan, R A, Abramson, S B, Amin, A R

“…A snake venom-like protease isolated by a differential display screen between normal and osteoarthritis (OA)-affected cartilage (designated as cSVP) has a cDNA…”
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Functional genomic analysis of type II IL-1beta decoy receptor: potential for gene therapy in human arthritis and inflammation by Attur, Mukundan G, Dave, Mandar N, Leung, Mary Y, Cipolletta, Christine, Meseck, Marcia, Woo, Savio L C, Amin, Ashok R

“…Gene expression arrays show that human epithelial cells and human arthritis-affected cartilage lack detectable amounts of mRNA for IL-1 antagonizing molecules:…”
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Functional Genomic Analysis in Arthritis-Affected Cartilage: Yin-Yang Regulation of Inflammatory Mediators by α5β1 and αVβ3 Integrins by Attur, Mukundan G., Dave, Mandar N., Clancy, Robert M., Patel, Indravadan R., Abramson, Steven B., Amin, Ashok R.

“…Abstract Osteoarthritis-affected cartilage exhibits enhanced expression of fibronectin (FN) and osteopontin (OPN) mRNA in differential display and…”
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