Search Results - "Attoub, Samir "

Carnosol induces ROS-mediated beclin1-independent autophagy and apoptosis in triple negative breast cancer by Al Dhaheri, Yusra, Attoub, Samir, Ramadan, Gaber, Arafat, Kholoud, Bajbouj, Khuloud, Karuvantevida, Noushad, AbuQamar, Synan, Eid, Ali, Iratni, Rabah

“…In this study we investigated the in vitro and in vivo anticancer effect of carnosol, a naturally occurring polyphenol, in triple negative breast cancer. We…”
Get full text

Notch Signaling in Cancer: Rationale and Strategies for Targeting by Alketbi, Aisha, Attoub, Samir

“…The Notch signaling pathway is a highly conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through affecting…”
Get more information

Exploring the Anticancer Potential of Origanum majorana Essential Oil Monoterpenes Alone and in Combination against Non-Small Cell Lung Cancer by Arafat, Kholoud, Al-Azawi, Aya Mudhafar, Sulaiman, Shahrazad, Attoub, Samir

“…Lung cancer is the second most commonly diagnosed cancer and has the highest mortality rate worldwide despite the remarkable advances in its treatment…”
Get full text

PD-1 Independent Role of PD-L1 in Triple-Negative Breast Cancer Progression by Alkaabi, Duaa, Arafat, Kholoud, Sulaiman, Shahrazad, Al-Azawi, Aya Mudhafar, Attoub, Samir

“…Triple-negative breast cancer (TNBC) is a type of breast malignancy characterized by a high proliferative rate and metastatic potential leading to treatment…”
Get full text

Impact of Sodium Dichloroacetate Alone and in Combination Therapies on Lung Tumor Growth and Metastasis by Al-Azawi, Aya, Sulaiman, Shahrazad, Arafat, Kholoud, Yasin, Javed, Nemmar, Abderrahim, Attoub, Samir

“…Metabolic reprogramming has been recognized as an essential emerging cancer hallmark. Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase…”
Get full text

Breast cancer survival and its prognostic factors in the United Arab Emirates: A retrospective study by Elobaid, Yusra, Aamir, Maria, Grivna, Michal, Suliman, Abubaker, Attoub, Samir, Mousa, Hussam, Ahmed, Luai A, Oulhaj, Abderrahim

“…Data on breast cancer survival and its prognostic factors are lacking in the United Arab Emirates (UAE). Sociodemographic and pathologic factors have been…”
Get full text

Butein and Frondoside-A Combination Exhibits Additive Anti-Cancer Effects on Tumor Cell Viability, Colony Growth, and Invasion and Synergism on Endothelial Cell Migration by Sulaiman, Shahrazad, Arafat, Kholoud, Al-Azawi, Aya Mudhafar, AlMarzooqi, Noura Abdulraouf, Lootah, Shamsa Nasser Ali Hussain, Attoub, Samir

“…Despite the significant advances in targeted- and immuno-therapies, lung and breast cancer are at the top list of cancer incidence and mortality worldwide as…”
Get full text

Author Correction: Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation by Attoub, Samir, Arafat, Kholoud, Hammadi, Nasseredine Kamel, Mester, Jan, Gaben, Anne-Marie

Get full text

Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells by Attoub, Samir, Arafat, Kholoud, Khalaf, Tamam, Sulaiman, Shahrazad, Iratni, Rabah

“…Over recent years, we have demonstrated that Frondoside A, a triterpenoid glycoside isolated from an Atlantic sea cucumber, has potent in vitro and in vivo…”
Get full text

Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3 by Alsamri, Halima, El Hasasna, Hussain, Al Dhaheri, Yusra, Eid, Ali H, Attoub, Samir, Iratni, Rabah

“…We have previously demonstrated that carnosol, a naturally occurring diterpene, inhibited cell viability and colony growth, as well as induced cell cycle…”
Get full text

Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation by Venkataraman, Balaji, Almarzooqi, Saeeda, Raj, Vishnu, Bhongade, Bhoomendra A, Patil, Rajesh B, Subramanian, Veedamali S, Attoub, Samir, Rizvi, Tahir A, Adrian, Thomas E, Subramanya, Sandeep B

“…Inflammatory bowel disease, comprising Crohn's disease (CD) and ulcerative colitis (UC), is often debilitating. The disease etiology is multifactorial,…”
Get full text

PTC-209 Anti-Cancer Effects Involved the Inhibition of STAT3 Phosphorylation by Sulaiman, Shahrazad, Arafat, Kholoud, Iratni, Rabah, Attoub, Samir

“…Introduction: Lung, breast, and colorectal cancers are the leading causes of cancer-related deaths despite many therapeutic options, including targeted therapy…”
Get full text

Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of NFκB signaling and reduction of nitric oxide production by Al Dhaheri, Yusra, Attoub, Samir, Arafat, Kholoud, Abuqamar, Synan, Viallet, Jean, Saleh, Alaaeldin, Al Agha, Hala, Eid, Ali, Iratni, Rabah

“…We have recently reported that Origanummajorana exhibits anticancer activity by promoting cell cycle arrest and apoptosis of the metastatic MDA-MB-231 breast…”
Get full text

Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo by Arafat, Kholoud, Sulaiman, Shahrazad, Al-Azawi, Aya Mudhafar, Yasin, Javed, Sugathan, Subi, Nemmar, Abderrahim, Karam, Sherif, Attoub, Samir

“…Current targeted- and immuno-therapies have prolonged the overall survival of non-small cell lung cancer (NSCLC) patients by few months in a small percentage…”
Get full text

Corrigendum: Carnosol, a natural polyphenol, inhibits migration, metastasis, and tumor growth of breast cancer via a ROS-dependent proteasome degradation of STAT3 by Alsamri, Halima, Hasasna, Hussain El, Dhaheri, Yusra Al, Eid, Ali H, Attoub, Samir, Iratni, Rabah

“…[This corrects the article DOI: 10.3389/fonc.2019.00743.]…”
Get full text

Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor by Aryappalli, Priyanka, Shabbiri, Khadija, Masad, Razan J, Al-Marri, Roadha H, Haneefa, Shoja M, Mohamed, Yassir A, Arafat, Kholoud, Attoub, Samir, Cabral-Marques, Otavio, Ramadi, Khalil B, Fernandez-Cabezudo, Maria J, Al-Ramadi, Basel K

“…Aberrantly high levels of tyrosine-phosphorylated signal transducer and activator of transcription 3 (p-STAT3) are found constitutively in ~50% of human lung…”
Get full text

Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo by Attoub, Samir, Sperandio, Olivier, Raza, Haider, Arafat, Kholoud, Al-Salam, Suhail, Al Sultan, Mahmood Ahmed, Al Safi, Maha, Takahashi, Takashi, Adem, Abdu

“…Phytochemical compounds are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. The purpose of this study was to…”
Get full text

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells by Attoub, Samir, Hassan, Ahmed H., Vanhoecke, Barbara, Iratni, Rabah, Takahashi, Takashi, Gaben, Anne-Marie, Bracke, Marc, Awad, Salma, John, Anne, Kamalboor, Hamda Ahmed, Al Sultan, Mahmood Ahmed, Arafat, Kholoud, Gespach, Christian, Petroianu, Georg

“…Phytochemical compounds and histone deacetylase (HDAC) inhibitors are emerging as a new generation of anticancer agents with limited toxicity in cancer…”
Get full text

Rhus coriaria induces autophagic and apoptotic cell death in pancreatic cancer cells by El Mahi, Yassine, Nizami, Zohra Nausheen, Wali, Adil Farooq, Al Neyadi, Aysha, Magramane, Mohamed, Al Azzani, Mazoun, Arafat, Kholoud, Attoub, Samir, Eid, Ali H, Iratni, Rabah

“…Pancreatic cancer is a leading cause of cancer-related mortality worldwide with increasing global incidence. We previously reported the anticancer effect of…”
Get full text

Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation by Al Dhaheri, Yusra, Attoub, Samir, Arafat, Kholoud, AbuQamar, Synan, Eid, Ali, Al Faresi, Nesreen, Iratni, Rabah

“…In the present study, we investigated the effect of Salinomycin on the survival of three human breast cancer cell lines MCF-7, T47D and MDA-MB-231 grown in…”
Get full text