Search Results - "Attig, Sebastian"

CD19 Isoforms Enabling Resistance to CART-19 Immunotherapy Are Expressed in B-ALL Patients at Initial Diagnosis by Fischer, Jeannette, Paret, Claudia, El Malki, Khalifa, Alt, Francesca, Wingerter, Arthur, Neu, Marie A, Kron, Bettina, Russo, Alexandra, Lehmann, Nadine, Roth, Lea, Fehr, Eva-M, Attig, Sebastian, Hohberger, Alexander, Kindler, Thomas, Faber, Jörg

“…B-cell acute lymphoblastic leukemia (B-ALL) is the commonest childhood cancer and the prognosis of children with relapsed or therapy refractory disease remains…”
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Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL by Ziegler, Nicole, Cortés-López, Mariela, Alt, Francesca, Sprang, Maximilian, Ustjanzew, Arsenij, Lehmann, Nadine, El Malki, Khalifa, Wingerter, Arthur, Russo, Alexandra, Beck, Olaf, Attig, Sebastian, Roth, Lea, König, Julian, Paret, Claudia, Faber, Jörg

“…Despite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted…”
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FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines by KREITER, Sebastian, DIKEN, Mustafa, SELMI, Abderraouf, DIEKMANN, Jan, ATTIG, Sebastian, HÜSEMANN, Yves, KOSLOWSKI, Michael, HUBER, Christoph, TÜREI, Ozlem, SAHIN, Ugur

“…Intranodal immunization with antigen-encoding naked RNA may offer a simple and safe approach to induce antitumor immunity. RNA taken up by nodal dendritic…”
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The gut microbiota instructs the hepatic endothelial cell transcriptome by Formes, Henning, Bernardes, Joana P., Mann, Amrit, Bayer, Franziska, Pontarollo, Giulia, Kiouptsi, Klytaimnistra, Schäfer, Katrin, Attig, Sebastian, Nikolova, Teodora, Hofmann, Thomas G., Schattenberg, Jörn M., Todorov, Hristo, Gerber, Susanne, Rosenstiel, Philip, Bopp, Tobias, Sommer, Felix, Reinhardt, Christoph

“…The gut microbiota affects remote organ functions but its impact on organotypic endothelial cell (EC) transcriptomes remains unexplored. The liver endothelium…”
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Improved method to retain cytosolic reporter protein fluorescence while staining for nuclear proteins by Heinen, André P., Wanke, Florian, Moos, Sonja, Attig, Sebastian, Luche, Hervé, Pal, Prajna Paramita, Budisa, Nediljko, Fehling, Hans Jörg, Waisman, Ari, Kurschus, Florian C.

“…Staining of transcription factors (TFs) together with retention of fluorescent reporter proteins is hindered by loss of fluorescence using current available…”
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A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols by Attig, Sebastian, Price, Leah, Janetzki, Sylvia, Kalos, Michael, Pride, Michael, McNeil, Lisa, Clay, Tim, Yuan, Jianda, Odunsi, Kunle, Hoos, Axel, Romero, Pedro, Britten, Cedrik M

“…The introduction of antibody markers to identify undesired cell populations in flow-cytometry based assays, so called DUMP channel markers, has become a…”
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An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma by Sahin, Ugur, Oehm, Petra, Derhovanessian, Evelyna, Jabulowsky, Robert A., Vormehr, Mathias, Gold, Maike, Maurus, Daniel, Schwarck-Kokarakis, Doreen, Kuhn, Andreas N., Omokoko, Tana, Kranz, Lena M., Diken, Mustafa, Kreiter, Sebastian, Haas, Heinrich, Attig, Sebastian, Rae, Richard, Cuk, Katarina, Kemmer-Brück, Alexandra, Breitkreuz, Andrea, Tolliver, Claudia, Caspar, Janina, Quinkhardt, Juliane, Hebich, Lisa, Stein, Malte, Hohberger, Alexander, Vogler, Isabel, Liebig, Inga, Renken, Stephanie, Sikorski, Julian, Leierer, Melanie, Müller, Verena, Mitzel-Rink, Heidrun, Miederer, Matthias, Huber, Christoph, Grabbe, Stephan, Utikal, Jochen, Pinter, Andreas, Kaufmann, Roland, Hassel, Jessica C., Loquai, Carmen, Türeci, Özlem

“…Treating patients who have cancer with vaccines that stimulate a targeted immune response is conceptually appealing, but cancer vaccine trials have not been…”
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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy by Kranz, Lena M., Diken, Mustafa, Haas, Heinrich, Kreiter, Sebastian, Loquai, Carmen, Reuter, Kerstin C., Meng, Martin, Fritz, Daniel, Vascotto, Fulvia, Hefesha, Hossam, Grunwitz, Christian, Vormehr, Mathias, Hüsemann, Yves, Selmi, Abderraouf, Kuhn, Andreas N., Buck, Janina, Derhovanessian, Evelyna, Rae, Richard, Attig, Sebastian, Diekmann, Jan, Jabulowsky, Robert A., Heesch, Sandra, Hassel, Jessica, Langguth, Peter, Grabbe, Stephan, Huber, Christoph, Türeci, Özlem, Sahin, Ugur

“…The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide…”
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Cytomegalovirus Infection by KOCH, SVEN, LARBI, ANIS, ÖZCELIK, DENNIS, SOLANA, RAFAEL, GOUTTEFANGEAS, CÉCILE, ATTIG, SEBASTIAN, WIKBY, ANDERS, STRINDHALL, JAN, FRANCESCHI, CLAUDIO, PAWELEC, GRAHAM

“…:  The human immune system evolved to defend the organism against pathogens, but is clearly less well able to do so in the elderly, resulting in greater…”
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Studies of S-adenosylhomocysteine-hydrolase polymorphism in a Croatian population by Kloor, Doris, Fumic, Ksenija, Attig, Sebastian, Tete, Martina, Osswald, Hartmut, Baric, Ivo, Tomiuk, Jürgen, Kömpf, Jost

“…Recently, a proven case of human S-adenosylhomocysteine-hydrolase (SAHH) deficiency was reported in a Croatian boy. As molecular analysis of the SAHH gene in…”
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Cytomegalovirus infection: a driving force in human T cell immunosenescence by Koch, Sven, Larbi, Anis, Ozcelik, Dennis, Solana, Rafael, Gouttefangeas, Cécile, Attig, Sebastian, Wikby, Anders, Strindhall, Jan, Franceschi, Claudio, Pawelec, Graham

“…The human immune system evolved to defend the organism against pathogens, but is clearly less well able to do so in the elderly, resulting in greater morbidity…”
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Gating Harmonization Guidelines for Intracellular Cytokine Staining Validated in Second International Multiconsortia Proficiency Panel Conducted by Cancer Immunotherapy Consortium (CIC/CRI) by Price, Leah S., Adamow, Matthew, Attig, Sebastian, Fecci, Peter, Norberg, Pamela, Reap, Elizabeth, Janetzki, Sylvia, McNeil, Lisa K.

“…Results from the first gating proficiency panel of intracellular cytokine staining (ICS) highlighted the value of using a consensus gating approach to reduce…”
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A shared tumor-antigen RNA-lipoplex vaccine with/without anti-PD1 in patients with checkpoint-inhibition experienced melanoma by Loquai, Carmen, Hassel, Jessica Cecile, Oehm, Petra, Derhovanessian, Evelyna, Jabulowsky, Robert Alexander, Gold, Maike, Schwarck-Kokarakis, Doreen, Attig, Sebastian, Cuk, Katarina, Vogler, Isabel, Sikorski, Julian, Leierer, Melanie, Mitzel-Rink, Heidrun, Miederer, Matthias, Grabbe, Stephan, Utikal, Jochen, Pinter, Andreas, Kaufmann, Roland, Sahin, Ugur, Tureci, Oezlem

“…Abstract only 3136 Background: Cancer vaccines are considered unsuitable for patients with advanced tumours and have not been clinically successful. Methods:…”
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Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas by Attig, Sebastian, Hennenlotter, Jörg, Pawelec, Graham, Klein, Gerd, Koch, Sven D, Pircher, Hanspeter, Feyerabend, Susan, Wernet, Dorothee, Stenzl, Arnulf, Rammensee, Hans-Georg, Gouttefangeas, Cécile

“…Renal cell carcinoma is frequently infiltrated by cells of the immune system. This makes it important to understand interactions between cancer cells and…”
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Promiscuous survivin peptide induces robust CD4+ T-cell responses in the majority of vaccinated cancer patients by Widenmeyer, Melanie, Griesemann, Heinrich, Stevanović, Stefan, Feyerabend, Susan, Klein, Reinhild, Attig, Sebastian, Hennenlotter, Jörg, Wernet, Dorothee, Kuprash, Dmitri V., Sazykin, Alexei Y., Pascolo, Steve, Stenzl, Arnulf, Gouttefangeas, Cécile, Rammensee, Hans-Georg

“…CD4+ T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor…”
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mTOR inhibition improves antitumor effects of vaccination with antigen-encoding RNA by Diken, Mustafa, Kreiter, Sebastian, Vascotto, Fulvia, Selmi, Abderraouf, Attig, Sebastian, Diekmann, Jan, Huber, Christoph, Türeci, Özlem, Sahin, Ugur

“…Vaccination with in vitro transcribed RNA encoding tumor antigens is an emerging approach in cancer immunotherapy. Attempting to further improve RNA vaccine…”
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Abstract CT156: A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles encoding shared tumor antigens for immunotherapy of malignant melanoma by Jabulowsky, Robert A., Loquai, Carmen, Mitzel-Rink, Heidrun, Utikal, Jochen, Gebhardt, Christoffer, Hassel, Jessica C., Kaufmann, Roland, Pinter, Andreas, Derhovanessian, Evelyna, Anft, Christine, Attig, Sebastian, Deubel, Alexandra, Diken, Mustafa, Gold, Maike, Guertler, Claudia, Haas, Heinrich, Heesen, Ludwig, Kemmer-Brück, Alexandra, Kranz, Lena M., Kuehlcke, Klaus, Kuhn, Andreas, Langguth, Peter, Luxemburger, Ulrich, Maurus, Daniel, Meng, Martin, Müller, Felicitas, Rae, Richard, Sari, Fatih, Schreeb, Katharina, Schwarck-Kokarakis, Doreen, Stein, Malte, Jäger, Dirk, Grabbe, Stephan, Kreiter, Sebastian, Huber, Christoph, Türeci, Özlem, Sahin, Ugur

“…Abstract Therapeutic vaccination with tumor antigen-encoding RNAs is being investigated in various clinical trials. Typically, the RNA vaccine is administered…”
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Abstract CT034: A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles for potent melanoma immunotherapy by Jabulowsky, Robert A., Loquai, Carmen, Utikal, Jochen, Hassel, Jessica, Kaufmann, Roland, Derhovanessian, Evelyna, Diken, Mustafa, Kranz, Lena M., Haas, Heinrich, Attig, Sebastian, Anft, Christine, Buck, Janina, Diekmann, Jan, Fritz, Daniel, Hartmann, Kerstin, Kemmer-Brueck, Alexandra, Kuehlcke, Klaus, Kuhn, Andreas N., Langguth, Peter, Luxemburger, Ulrich, Meng, Martin, Rae, Richard, Sari, Fatih, Schwarck-Kokarakis, Doreen, Stein, Malte, Grabbe, Stephan, Kreiter, Sebastian, Tuereci, Oezlem, Huber, Christoph, Sahin, Ugur

“…Abstract Therapeutic vaccination with tumor antigen-encoding RNAs by local administration is currently being successfully employed in various clinical trials…”
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Functional TCR retrieval from single antigen-specific human T cells reveals multiple novel epitopes by Simon, Petra, Omokoko, Tana A, Breitkreuz, Andrea, Hebich, Lisa, Kreiter, Sebastian, Attig, Sebastian, Konur, Abdo, Britten, Cedrik M, Paret, Claudia, Dhaene, Karl, Türeci, Özlem, Sahin, Ugur

“…The determination of the epitope specificity of disease-associated T-cell responses is relevant for the development of biomarkers and targeted immunotherapies…”
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Generation of TCR-engineered T cells and their use to control the performance of T cell assays by Bidmon, Nicole, Attig, Sebastian, Rae, Richard, Schröder, Helene, Omokoko, Tana A, Simon, Petra, Kuhn, Andreas N, Kreiter, Sebastian, Sahin, Ugur, Gouttefangeas, Cécile, van der Burg, Sjoerd H, Britten, Cedrik M

“…The systematic assessment of the human immune system bears huge potential to guide rational development of novel immunotherapies and clinical decision making…”
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