Search Results - "Attia, Hala A."
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Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines
Published in Scientific reports (24-02-2020)“…Depression is still one of challenging, and widely encountered disorders with complex etiology. The role of healthy diet and olive oil in ameliorating…”
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Anti-Proliferative Activity of Glucagon-Like Peptide-1 Receptor Agonist on Obesity-Associated Breast Cancer: The Impact on Modulating Adipokines’ Expression in Adipocytes and Cancer Cells
Published in Dose-response (01-01-2021)“…Obesity is associated with high risk and poor prognosis of breast cancer (BC). Obesity promotes BC cells proliferation via modulating the production of…”
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3
Roles of some antioxidants in modulation of cardiac myopathy induced by sodium nitrite via down-regulation of mRNA expression of NF-κB, Bax, and flt-1 and suppressing DNA damage
Published in Saudi pharmaceutical journal (01-02-2018)“…The underlying pathology of cardiac damage involves various molecular and signaling pathways. Therefore, this study aimed to explore the role of Quercetin…”
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Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats
Published in Acta Pharmaceutica (01-03-2017)“…The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of…”
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Preventive effects of selenium yeast, chromium picolinate, zinc sulfate and their combination on oxidative stress, inflammation, impaired angiogenesis and atherogenesis in myocardial infarction in rats
Published in Journal of pharmacy & pharmaceutical sciences (01-01-2013)“…Accumulating evidences suggest a critical role of trace metal dyshemostasis in oxidative stress and cardiac dysfunction after myocardial infarction (MI). This…”
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Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor-β1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats
Published in Evidence-based complementary and alternative medicine (01-01-2015)“…Previous data indicated the protective effect of date fruit extract on oxidative damage in rat liver. However, the hepatoprotective effects via other…”
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7
Hepatoprotective activity of raspberry ketone is mediated via inhibition of the NF-κB/TNF-α/caspase axis and mitochondrial apoptosis in chemically induced acute liver injury
Published in Toxicology research (Cambridge) (01-09-2019)“…Raspberry Ketone (RK) is a natural phenolic compound which is marketed nowadays as a popular weight-reducing remedy, with reported antioxidant and…”
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Curcumin and Selenium Prevent Lipopolysaccharide/Diclofenac-Induced Liver Injury by Suppressing Inflammation and Oxidative Stress
Published in Biological trace element research (01-07-2020)“…Diclofenac (DCL), an anti-inflammatory drug used to reduce pain and inflammation, ranks in the top causes of drug-induced liver injury. The inflammatory stress…”
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The protective role of sesame oil against Parkinson's-like disease induced by manganese in rats
Published in Behavioural brain research (08-05-2024)“…Chronic exposure to manganese (Mn) results in motor dysfunction, biochemical and pathological alterations in the brain. Oxidative stress, inflammation, and…”
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Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy
Published in Biomedicine & pharmacotherapy (01-11-2018)“…The present study aimed to investigate the protective effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on diabetic cardiomyopathy (DCM)-associated…”
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Quercetin inhibits sodium nitrite‐induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1‐α, TGF‐β, Smad‐2, and AKT pathways
Published in Journal of biochemical and molecular toxicology (01-05-2017)“…The objective of this work is to study the protective effects of Quercetin against sodium nitrite‐induced hypoxia on liver, lung, kidney and cardiac tissues,…”
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Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor- β 1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats
Published in Evidence-based complementary and alternative medicine (2015)“…Previous data indicated the protective effect of date fruit extract on oxidative damage in rat liver. However, the hepatoprotective effects via other…”
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13
Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-[beta]1/Smad and GRAP pathways
Published in Journal of pharmacy and pharmacology (01-02-2016)“…Objective To investigate whether ruboxistaurin (a selective PKC-[beta] inhibitor) mediates renoprotective effect via interference with TGF-[beta]1/Smad-GRAP…”
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14
Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways
Published in Journal of pharmacy and pharmacology (01-02-2016)“…Objective To investigate whether ruboxistaurin (a selective PKC‐β inhibitor) mediates renoprotective effect via interference with TGF‐β1/Smad‐GRAP…”
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15
Attenuation of DNA damage and mRNA gene expression in hypoxic rats using natural antioxidants
Published in Journal of biochemical and molecular toxicology (01-12-2017)“…This study aimed to explore the efficiency of carnosine (Cs) and/or l‐arginine (Agn) in the downregulation of apoptotic and inflammatory molecule expression…”
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Downregulation of flt-1 and HIF-1α Gene Expression by Some Antioxidants in Rats Under Sodium Nitrite–Induced Hypoxic Stress
Published in Dose-response (01-04-2018)“…This study assessed the effect of L-arginine (L-argin), carnosine (carno), or their combination in the amelioration of certain biochemical indices induced in…”
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17
Date fruits inhibit hepatocyte apoptosis and modulate the expression of hepatocyte growth factor, cytochrome P450 2E1 and heme oxygenase-1 in carbon tetrachloride-induced liver fibrosis
Published in Archives of physiology and biochemistry (01-05-2017)“…Context: Date fruits have protective effects against liver fibrosis; however their anti-apoptotic effects have not been investigated. Objective: To investigate…”
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Renoprotective Effects of Fenofibrate via Modulation of LKB1/AMPK mRNA Expression and Endothelial Dysfunction in a Rat Model of Diabetic Nephropathy
Published in Pharmacology (01-06-2015)“…This study was conducted to investigate whether the renoprotective effects of fenofibrate are mediated via attenuation of endothelial dysfunction and…”
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Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model
Published in Brazilian Archives of Biology and Technology (2016)“…This study aimed to explore the effective role of carnosine and /or L- arginine in down regulation of the inflammatory molecule expression caused renal damage…”
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20
Adverse cardiac responses to alpha-lipoic acid in a rat-diabetic model: possible mechanisms?
Published in Journal of physiology and biochemistry (01-12-2013)“…Alpha-lipoic acid (ALA) is widely used as an antioxidant for the treatment of diabetes and its complications; however, the pro-oxidant potential of ALA has…”
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