Search Results - "Attems, Johannes"

Interactions of pathological proteins in neurodegenerative diseases by Spires-Jones, Tara L., Attems, Johannes, Thal, Dietmar Rudolf

“…Neurodegenerative diseases such as Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTD), Lewy body disease (LBD), Parkinson’s disease (PD), and…”
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Olfactory bulb involvement in neurodegenerative diseases by Attems, Johannes, Walker, Lauren, Jellinger, Kurt A.

“…Olfactory dysfunction is a common and early symptom of many neurodegenerative diseases, particularly of Parkinson’s disease and other synucleinopathies,…”
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Olfaction and Aging: A Mini-Review by Attems, Johannes, Walker, Lauren, Jellinger, Kurt A

“…Decreased olfactory function is very common in the older population, being present in >50% of individuals aged between 65 and 80 years and in 62-80% of those…”
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Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms by Attems, Johannes

“…Cerebral amyloid angiopathy (CAA) was observed for the first time nearly 100 years ago and systematically described in 1938. It is a common finding in elderly…”
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Dementia with Lewy bodies: an update and outlook by Outeiro, Tiago Fleming, Koss, David J, Erskine, Daniel, Walker, Lauren, Kurzawa-Akanbi, Marzena, Burn, David, Donaghy, Paul, Morris, Christopher, Taylor, John-Paul, Thomas, Alan, Attems, Johannes, McKeith, Ian

“…Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and…”
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Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies by Thal, Dietmar Rudolf, Attems, Johannes, Ewers, Michael

“…Primary pathologies including amyloid-β (Aβ) plaques and neurofibrillary tangles (NFT) develop many years before the onset of dementia symptoms in Alzheimer's…”
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Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study by Ivashko-Pachima, Yanina, Hadar, Adva, Grigg, Iris, Korenková, Vlasta, Kapitansky, Oxana, Karmon, Gidon, Gershovits, Michael, Sayas, C. Laura, Kooy, R. Frank, Attems, Johannes, Gurwitz, David, Gozes, Illana

“…With Alzheimer’s disease (AD) exhibiting reduced ability of neural stem cell renewal, we hypothesized that de novo mutations controlling embryonic development,…”
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Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders by Erskine, Daniel, Koss, David, Korolchuk, Viktor I., Outeiro, Tiago F., Attems, Johannes, McKeith, Ian

“…Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy bodies (LBs) is the characteristic neuropathological feature of LB…”
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Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study by Attems, Johannes, Toledo, Jon B., Walker, Lauren, Gelpi, Ellen, Gentleman, Steve, Halliday, Glenda, Hortobagyi, Tibor, Jellinger, Kurt, Kovacs, Gabor G., Lee, Edward B., Love, Seth, McAleese, Kirsty E., Nelson, Peter T., Neumann, Manuela, Parkkinen, Laura, Polvikoski, Tuomo, Sikorska, Beata, Smith, Colin, Grinberg, Lea Tenenholz, Thal, Dietmar R., Trojanowski, John Q., McKeith, Ian G.

“…Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include the Braak Lewy body…”
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White matter connections of the supplementary motor area in humans by Vergani, Francesco, Lacerda, Luis, Martino, Juan, Attems, Johannes, Morris, Christopher, Mitchell, Patrick, de Schotten, Michel Thiebaut, Dell'Acqua, Flavio

“…Introduction The supplementary motor area (SMA) is frequently involved by brain tumours (particularly WHO grade II gliomas). Surgery in this area can be…”
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Phosphorylation of different tau sites during progression of Alzheimer's disease by Neddens, Joerg, Temmel, Magdalena, Flunkert, Stefanie, Kerschbaumer, Bianca, Hoeller, Christina, Loeffler, Tina, Niederkofler, Vera, Daum, Guenther, Attems, Johannes, Hutter-Paier, Birgit

“…Alzheimer's disease is characterized by accumulation of amyloid plaques and tau aggregates in several cortical brain regions. Tau phosphorylation causes…”
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Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology by McAleese, Kirsty E., Miah, Mohi, Graham, Sophie, Hadfield, Georgina M., Walker, Lauren, Johnson, Mary, Colloby, Sean J., Thomas, Alan J., DeCarli, Charles, Koss, David, Attems, Johannes

“…Cerebral white matter lesions (WML) encompass axonal loss and demyelination and are assumed to be associated with small vessel disease (SVD)-related ischaemia…”
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Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes by Walker, Lauren, McAleese, Kirsty E., Thomas, Alan J., Johnson, Mary, Martin-Ruiz, Carmen, Parker, Craig, Colloby, Sean J., Jellinger, Kurt, Attems, Johannes

“…Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the…”
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Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein by Pinho, Raquel, Paiva, Isabel, Jerčić, Kristina Gotovac, Fonseca-Ornelas, Luis, Gerhardt, Ellen, Fahlbusch, Christiane, Garcia-Esparcia, Paula, Kerimoglu, Cemil, Pavlou, Maria A S, Villar-Piqué, Anna, Szegő, Éva, Lopes da Fonseca, Tomás, Odoardi, Francesca, Soeroes, Szabolcs, Rego, Ana Cristina, Fischle, Wolfgang, Schwamborn, Jens C, Meyer, Thomas, Kügler, Sebastian, Ferrer, Isidre, Attems, Johannes, Fischer, André, Becker, Stefan, Zweckstetter, Markus, Borovecki, Fran, Outeiro, Tiago F

“…Abstract Alpha-synuclein (aSyn) is a central player in Parkinson's disease (PD) but the precise molecular mechanisms underlying its pathogenicity remain…”
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Neuropathological correlates of cerebral multimorbidity by Attems, Johannes, Jellinger, Kurt

“…Age associated neurodegenerative diseases are characterized by intra- and extracellular aggregation and deposition of misfolded proteins. The neuropathological…”
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Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis by Carroll, Bernadette, Otten, Elsje G., Manni, Diego, Stefanatos, Rhoda, Menzies, Fiona M., Smith, Graham R., Jurk, Diana, Kenneth, Niall, Wilkinson, Simon, Passos, Joao F., Attems, Johannes, Veal, Elizabeth A., Teyssou, Elisa, Seilhean, Danielle, Millecamps, Stéphanie, Eskelinen, Eeva-Liisa, Bronowska, Agnieszka K., Rubinsztein, David C., Sanz, Alberto, Korolchuk, Viktor I.

“…Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated by basic mechanisms that are conserved throughout the eukaryotic…”
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Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders by Patterson, Lina, Rushton, Steven P., Attems, Johannes, Thomas, Alan J., Morris, Christopher M.

“…Aims Depression is commonly observed even in prodromal stages of Lewy body disorders (LBD), and is associated with cognitive impairment and a faster rate of…”
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Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology by Perry, Elaine K, Johnson, Mary, Ekonomou, Antigoni, Perry, Robert H, Ballard, Clive, Attems, Johannes

“…Abstract Neurogenesis occurs in the subventricular zone and the sub-granular layer of the hippocampus and is thought to take place in 5 stages, including…”
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Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models by Neddens, Joerg, Daurer, Magdalena, Flunkert, Stefanie, Beutl, Kerstin, Loeffler, Tina, Walker, Lauren, Attems, Johannes, Hutter-Paier, Birgit

“…Senile plaques frequently contain Aβ-pE(3), a N-terminally truncated Aβ species that is more closely linked to AD compared to other Aβ species. Tau protein is…”
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Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia by Bereczki, Erika, Francis, Paul T, Howlett, David, Pereira, Joana B, Höglund, Kina, Bogstedt, Anna, Cedazo-Minguez, Angel, Baek, Jean-Ha, Hortobágyi, Tibor, Attems, Johannes, Ballard, Clive, Aarsland, Dag

“…Abstract Introduction Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A,…”
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