Search Results - "Attali, B."
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1
The role of the I sK protein in the specific pharmacological properties of the I Ks channel complex
Published in British journal of pharmacology (05-02-2009)“…I Ks channels are composed of I sK and KvLQT1 subunits and underly the slowly activating, voltage‐dependent I Ks conductance in heart. Although it appears…”
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2
Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties
Published in Molecular pharmacology (01-04-2005)“…The voltage-dependent M-type potassium current (M-current) plays a major role in controlling brain excitability by stabilizing the membrane potential and…”
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3
The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes
Published in British journal of pharmacology (01-03-1997)“…The antipsychotic drug haloperidol can induce a marked QT prolongation and polymorphic ventricular arrhythmias. In this study, we expressed several cloned…”
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4
Molecular impact of MinK on the enantiospecific block of IKs by chromanols
Published in British journal of pharmacology (01-12-2000)“…Slowly activating IKs (KCNQ1/MinK) channels were expressed in Xenopous oocytes and their sensitivity to chromanols was compared to homomeric KCNQ1 channels. To…”
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5
A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes
Published in Proceedings of the National Academy of Sciences - PNAS (20-06-1995)“…Screening a rat colon cDNA library for aldosterone-induced genes resulted in the molecular cloning of a cDNA whose corresponding mRNA is strongly induced in…”
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6
Hypomyelination and increased activity of voltage-gated K+ channels in mice lacking protein tyrosine phosphatase ϵ
Published in The EMBO journal (01-08-2000)“…Protein tyrosine phosphatase epsilon (PTPϵ) is strongly expressed in the nervous system; however, little is known about its physiological role. We report that…”
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7
External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids
Published in Proceedings of the National Academy of Sciences - PNAS (01-03-1994)“…The present work shows that arachidonic acid and some other long chain polyunsaturated fatty acids such as docosahexaenoic acid, which is abundant in fish oil,…”
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8
Modulation of homomeric and heteromeric KCNQ1 channels by external acidification
Published in The Journal of physiology (15-12-2002)“…The I KS K + channel plays a major role in repolarizing the cardiac action potential. It consists of an assembly of two structurally distinct α and β…”
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9
Is the WKL1 gene associated with schizophrenia?
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (15-02-2004)“…A missense mutation Leu309Met in the WKL1 (MLC1, KIAA0027) gene, mapped to 22q13.3, was reported to co‐segregate with periodic catatonic schizophrenia (SCZ) in…”
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10
Overexpression of mouse IsK protein fused to green fluorescent protein induces apoptosis of human astroglioma cells
Published in Neurological research (New York) (01-09-2007)“…Intracellular K + plays an important role in controlling ion homeostasis for maintaining cell volume and inhibiting activity of pro-apoptotic enzymes…”
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11
BA6b9, a novel sk4 K + channel blocker, attenuates atrial fibrillation substrate in rats with reduced ejection fraction
Published in European heart journal (28-10-2024)“…Abstract Background Atrial fibrillation (AF), the most common cardiac arrhythmia, is strongly associated with several comorbidities including heart failure…”
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12
Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart
Published in The EMBO journal (01-10-1991)“…Neonatal mouse cardiac poly(A)+ mRNA microinjection into Xenopus oocytes directed the expression of a delayed rectifier K+ current. A cDNA encoding this…”
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13
The Concise Guide to PHARMACOLOGY 2015/16: Enzymes
Published in British journal of pharmacology (01-12-2015)“…The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links…”
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview
Published in British journal of pharmacology (01-12-2017)“…The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties…”
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The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors
Published in British journal of pharmacology (01-12-2015)“…The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links…”
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16
The Concise Guide to PHARMACOLOGY 2015/16: Overview
Published in British journal of pharmacology (01-12-2015)“…The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links…”
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17
The C-terminus of Kv7 channels: a multifunctional module
Published in The Journal of physiology (01-04-2008)“…Kv7 channels (KCNQ) represent a family of voltage-gated K + channels which plays a prominent role in brain and cardiac excitability. Their physiological…”
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The Concise Guide to PHARMACOLOGY 2015/16: Transporters
Published in British journal of pharmacology (01-12-2015)“…The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links…”
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19
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes
Published in The Journal of biological chemistry (25-04-1992)“…Low stringency screening of a Jurkat cDNA library with a rat brain K+ channel (RCK1) probe has resulted in the isolation of HLK3, a voltage-gated K+ channel…”
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The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels
Published in British journal of pharmacology (01-12-2015)“…The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links…”
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