Search Results - "Atsufumi Kawabata"

Prostaglandin E2 and Pain—An Update by Kawabata, Atsufumi

“…Prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, is the best known lipid mediator that contributes to inflammatory pain. Nonsteroidal anti-inflammatory…”
Get full text

Role of HMGB1 in Chemotherapy-Induced Peripheral Neuropathy by Sekiguchi, Fumiko, Kawabata, Atsufumi

“…Chemotherapy-induced peripheral neuropathy (CIPN), one of major dose-limiting side effects of first-line chemotherapeutic agents such as paclitaxel,…”
Get full text

Role of high‐mobility group box 1 and its modulation by thrombomodulin/thrombin axis in neuropathic and inflammatory pain by Tsujita, Ryuichi, Tsubota, Maho, Sekiguchi, Fumiko, Kawabata, Atsufumi

“…High‐mobility group box 1 (HMGB1), a nuclear protein, once released to the extracellular space, facilitates pain signals as well as inflammation. Intraplantar…”
Get full text

Macrophage as a Peripheral Pain Regulator by Domoto, Risa, Sekiguchi, Fumiko, Tsubota, Maho, Kawabata, Atsufumi

“…A neuroimmune crosstalk is involved in somatic and visceral pathological pain including inflammatory and neuropathic components. Apart from microglia essential…”
Get full text

Dietary Zinc Deficiency Induces Cav3.2-Dependent Nociceptive Hypersensitivity in Mice by Tomita, Shiori, Sekiguchi, Fumiko, Tsubota, Maho, Kawabata, Atsufumi

“…Cav3.2 channels belong to the T-type calcium channel (T-channel) family, i.e., low voltage-activated calcium channels, and are abundantly expressed in the…”
Get full text

Risk factors and pharmacotherapy for chemotherapy-induced peripheral neuropathy in paclitaxel-treated female cancer survivors: A retrospective study in Japan by Hiramoto, Shiori, Asano, Hajime, Miyamoto, Tomoyoshi, Takegami, Manabu, Kawabata, Atsufumi

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting adverse reaction in cancer patients treated with several cytotoxic anticancer agents…”
Get full text

T-type Calcium Channels: Functional Regulation and Implication in Pain Signaling by Sekiguchi, Fumiko, Kawabata, Atsufumi

“…Low-voltage-activated T-type Ca2+ channels (T-channels), especially Cav3.2 among the three isoforms (Cav3.1, Cav3.2, and Cav3.3), are now considered to play…”
Get full text

Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk by Sekiguchi, Fumiko, Domoto, Risa, Nakashima, Kana, Yamasoba, Daichi, Yamanishi, Hiroki, Tsubota, Maho, Wake, Hidenori, Nishibori, Masahiro, Kawabata, Atsufumi

“…Given our recent evidence for the role of high mobility group box 1 (HMGB1) in chemotherapy-induced peripheral neuropathy (CIPN) in rats, we examined the…”
Get full text

Development of diabetes mellitus following hormone therapy in prostate cancer patients is associated with early progression to castration resistance by Hayashi, Tomonori, Miyamoto, Tomoyoshi, Nagai, Noriaki, Kawabata, Atsufumi

“…To identify risk factors for the prognosis of prostate cancer (PC), we retrospectively analyzed the impact of lifestyle-related disorders as well as PC…”
Get full text

Involvement of Voltage-Gated Calcium Channels in Inflammation and Inflammatory Pain by Sekiguchi, Fumiko, Tsubota, Maho, Kawabata, Atsufumi

“…Voltage-gated calcium channels (VGCCs) are classified into high-voltage-activated (HVA) channels and low-voltage-activated channels consisting of Cav3.1–3.3,…”
Get full text

Endogenous Hydrogen Sulfide Enhances Cell Proliferation of Human Gastric Cancer AGS Cells by Sekiguchi, Fumiko, Sekimoto, Teruki, Ogura, Ayaka, Kawabata, Atsufumi

“…Hydrogen sulfide (H2S), the third gasotransmitter, is endogenously generated by certain H2S synthesizing enzymes, including cystathionine-γ-lyase (CSE) and…”
Get full text

Effects of Bepridil and Pimozide, Existing Medicines Capable of Blocking T-Type Ca2+ Channels, on Visceral Pain in Mice by Tsubota, Maho, Matsui, Kazuki, Fukushi, Saaya, Okazaki, Kyoko, Sekiguchi, Fumiko, Kawabata, Atsufumi

“…T-Type Ca2+ channels (T-channels), particularly Cav3.2, are now considered as therapeutic targets for treatment of intractable pain including visceral pain…”
Get full text

Characterization of Potentially Inappropriate Medications That Need Special Attention in the Elderly with Dementia by Analyzing Pharmacy Claims Data by Kasanami, Yoshihito, Yamamoto, Takashi, Miyamoto, Tomoyoshi, Matzno, Sumio, Sakakibara, Mikio, Iwaki, Masahiro, Kawabata, Atsufumi

“…Community pharmacists may play a key role in promoting deprescribing of potential inappropriate medications (PIMs) that are highly prevalent among…”
Get full text

Opposing impact of hypertension/diabetes following hormone therapy initiation and preexisting statins on castration resistant progression of nonmetastatic prostate cancer: a multicenter study by Hayashi, Tomonori, Miyamoto, Tomoyoshi, Iwane, Shiori, Fujitani, Masanori, Uchitani, Kazuki, Koizumi, Yuichi, Hirata, Atsushi, Kinoshita, Hidefumi, Kawabata, Atsufumi

“…Hormone therapy, especially androgen deprivation therapy (ADT), is effective against prostate cancer (PC), whereas long-term ADT is a risk for…”
Get full text

Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study by Miyamoto, Tomoyoshi, Hiramoto, Shiori, Kanto, Ayano, Tsubota, Maho, Fujitani, Masanori, Fukuyama, Hiroki, Hatanaka, Shigekatsu, Sekiguchi, Fumiko, Koizumi, Yuichi, Kawabata, Atsufumi

“…We performed clinical retrospective study in female cancer patients and fundamental experiments in mice, in order to clarify risk factors for…”
Get full text

H2S and Pain: A Novel Aspect for Processing of Somatic, Visceral and Neuropathic Pain Signals by Terada, Yuka, Kawabata, Atsufumi

“…Hydrogen sulfide (H2S) formed by multiple enzymes including cystathionine-γ-lyase (CSE) targets Cav3.2 T-type Ca2+ channels (T-channels) and transient receptor…”
Get more information

A Combination of Cryopreservation and Kneading Maintains the Usability of Mohs Paste by Okamoto, Hiroyo, Yoshikawa, Tomohiro, Takeuchi, Kenta, Deguchi, Saori, Hatakenaka, Yuto, Matsuoka, Hiroshi, Kawabata, Atsufumi, Nagai, Noriaki

“…Mohs paste is useful for controlling exudates from wounds and infections and is used to treat patients with inoperable skin tumors. Unfortunately, Mohs paste…”
Get full text

Changes in Percutaneous Absorption of Fentanyl Patches in Rats Treated with a Sebum-Like Secretion by Hayashi, Tomonori, Kawaguchi, Hinako, Eifuku, Tsumugi, Matsuoka, Hiroshi, Kawabata, Atsufumi, Nagai, Noriaki

“…The percutaneous absorption of a fentanyl (FEN)-patch is affected by various external factors including the volume of sebum secretion, which causes changes in…”
Get full text

Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants by Tsubota, Maho, Fukuda, Ryotaro, Hayashi, Yusuke, Miyazaki, Takaya, Ueda, Shin, Yamashita, Rika, Koike, Nene, Sekiguchi, Fumiko, Wake, Hidenori, Wakatsuki, Shuji, Ujiie, Yuka, Araki, Toshiyuki, Nishibori, Masahiro, Kawabata, Atsufumi

“…Macrophage-derived high mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) protein, plays a key role in the development of…”
Get full text

Clinical and preclinical evidence that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers prevent diabetic peripheral neuropathy by Iwane, Shiori, Nemoto, Wataru, Miyamoto, Tomoyoshi, Hayashi, Tomonori, Tanaka, Masayuki, Uchitani, Kazuki, Muranaka, Tatsuya, Fujitani, Masanori, Koizumi, Yuichi, Hirata, Atsushi, Tsubota, Maho, Sekiguchi, Fumiko, Tan-No, Koichi, Kawabata, Atsufumi

“…Given possible involvement of the central and peripheral angiotensin system in pain processing, we conducted clinical and preclinical studies to test whether…”
Get full text