Search Results - "Atreya, C E"

A phase II study of axitinib in advanced neuroendocrine tumors by Strosberg, J R, Cives, M, Hwang, J, Weber, T, Nickerson, M, Atreya, C E, Venook, A, Kelley, R K, Valone, T, Morse, B, Coppola, D, Bergsland, E K

“…Neuroendocrine tumors (NETs) are highly vascular neoplasms overexpressing vascular endothelial growth factor (VEGF) as well as VEGF receptors (VEGFR). Axitinib…”
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Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors by Ducker, G S, Atreya, C E, Simko, J P, Hom, Y K, Matli, M R, Benes, C H, Hann, B, Nakakura, E K, Bergsland, E K, Donner, D B, Settleman, J, Shokat, K M, Warren, R S

“…The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But…”
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Efficacy and circulating tumor DNA (ctDNA) analysis of the BRAF inhibitor dabrafenib (D), MEK inhibitor trametinib (T), and anti-EGFR antibody panitumumab (P) in patients (pts) with BRAF V600E–mutated (BRAFm) metastatic colorectal cancer (mCRC) by Corcoran, R.B., André, T., Yoshino, T., Bendell, J.C., Atreya, C.E., Schellens, J.H.M., Ducreux, M.P., McRee, A., Siena, S., Middleton, G., Gordon, M., Humblet, Y., Muro, K., Elez, E., Yaeger, R., Sidhu, R., Squires, M., Jaeger, S., Rangwala, F., Van Cutsem, E.

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Nonconserved Residues Ala287 and Ser290 of the Cryptosporidium hominis Thymidylate Synthase Domain Facilitate Its Rapid Rate of Catalysis by Doan, Lanxuan T, Martucci, W. Edward, Vargo, Melissa A, Atreya, Chloé E, Anderson, Karen S

“…Cryptosporidium hominis TS-DHFR exhibits an unusually high rate of catalysis at the TS domain, at least 10-fold greater than those of other TS enzymes. Using…”
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Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior by Atreya, Chloé E, Anderson, Karen S

“…This study presents a kinetic characterization of the recently crystallized bifunctional thymidylate synthasedihydrofolate reductase (TS-DHFR) enzyme from the…”
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Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity by Johnson, Eric F, Hinz, Wolfgang, Atreya, Chloe E, Maley, Frank, Anderson, Karen S

“…This study describes the use of rapid transient kinetic methods to characterize the bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) enzyme…”
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A Molecular Docking Strategy Identifies Eosin B as a Non-active Site Inhibitor of Protozoal Bifunctional Thymidylate Synthase-Dihydrofolate Reductase by Atreya, Chloé E., Johnson, Eric F., Irwin, John J., Dow, Antonia, Massimine, Kristen M., Coppens, Isabelle, Stempliuk, Valeska, Beverley, Stephen, Joiner, Keith A., Shoichet, Brian K., Anderson, Karen S.

“…Protozoal parasites are unusual in that their thymidylate synthase (TS) and dihydrofolate reductase (DHFR) enzymes exist on a single polypeptide. In an effort…”
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Probing Electrostatic Channeling in Protozoal Bifunctional Thymidylate Synthase-Dihydrofolate Reductase Using Site-directed Mutagenesis by Atreya, Chloé E., Johnson, Eric F., Williamson, Jessica, Chang, Sing-Yang, Liang, Po-Huang, Anderson, Karen S.

“…In this study we used site-directed mutagenesis to test the hypothesis that substrate channeling in the bifunctional thymidylate synthase-dihydrofolate…”
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