Search Results - "Atorrasagasti, Catalina"

The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease by Atorrasagasti, Catalina, Onorato, Agostina M., Mazzolini, Guillermo

“…Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix glycoprotein with pleiotropic functions, which is expressed in adipose,…”
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A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets by Bayo, Juan, Fiore, Esteban J., Dominguez, Luciana M., Real, Alejandrina, Malvicini, Mariana, Rizzo, Manglio, Atorrasagasti, Catalina, García, Mariana G., Argemi, Josepmaria, Martinez, Elisabeth D., Mazzolini, Guillermo D.

“…[Display omitted] •Mutations and expression alterations of epigenetic modifiers are frequent in HCC.•Jumonji lysine demethylase inhibitors normalize aggressive…”
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4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice by Rodríguez, Marcelo M., Onorato, Agostina, Cantero, María José, Domínguez, Luciana, Bayo, Juan, Fiore, Esteban, García, Mariana, Atorrasagasti, Catalina, Canbay, Ali, Malvicini, Mariana, Mazzolini, Guillermo D.

“…Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME)…”
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Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice by Fiore, Esteban, Domínguez, Luciana M., Bayo, Juan, Malvicini, Mariana, Atorrasagasti, Catalina, Rodriguez, Marcelo, Cantero, María José, García, Mariana, Yannarelli, Gustavo, Mazzolini, Guillermo

“…Extracellular vesicles (EVs) can mediate mesenchymal stromal cells (MSCs) paracrine effects. We aimed to evaluate the therapeutic potential of human umbilical…”
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Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence by Mazzolini, Guillermo, Sowa, Jan-Peter, Atorrasagasti, Catalina, Kücükoglu, Özlem, Syn, Wing-Kin, Canbay, Ali

“…Non-alcoholic fatty liver disease (NAFLD) is defined clinicopathologically by the accumulation of lipids in >5% of hepatocytes and the exclusion of secondary…”
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SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease by Mazzolini, Guillermo, Atorrasagasti, Catalina, Onorato, Agostina, Peixoto, Estanislao, Schlattjan, Martin, Sowa, Jan-Peter, Sydor, Svenja, Gerken, Guido, Canbay, Ali

“…Mechanisms that control progression from simple steatosis to steato-hepatitis and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) are…”
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Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for arrhythmogenic cardiomyopathy in vitro modeling by Amin, Guadalupe, Castañeda, Sheila Lucía, Zabalegui, Federico, Belli, Carolina, Atorrasagasti, Catalina, Miriuka, Santiago Gabriel, Moro, Lucía Natalia

“…The arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by the progressive replacement of contractile myocardium by…”
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Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice by Domínguez, Luciana M, Bueloni, Bárbara, Cantero, Ma José, Albornoz, Milagros, Pacienza, Natalia, Biani, Celeste, Luzzani, Carlos, Miriuka, Santiago, García, Mariana, Atorrasagasti, Catalina, Yannarelli, Gustavo, Bayo, Juan, Fiore, Esteban, Mazzolini, Guillermo

“…New therapeutic options for liver cirrhosis are needed. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as a promising tool for…”
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Modified mesenchymal stromal cells by in vitro transcribed mRNA: a therapeutic strategy for hepatocellular carcinoma by Cantero, María José, Bueloni, Barbara, Gonzalez Llamazares, Lucrecia, Fiore, Esteban, Lameroli, Lucia, Atorrasagasti, Catalina, Mazzolini, Guillermo, Malvicini, Mariana, Bayo, Juan, García, Mariana G

“…Mesenchymal stromal cells (MSCs) tropism for tumours allows their use as carriers of antitumoural factors and in vitro transcribed mRNA (IVT mRNA) is a…”
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4-methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis by Piccioni, Flavia, Fiore, Esteban, Bayo, Juan, Atorrasagasti, Catalina, Peixoto, Estanislao, Rizzo, Manglio, Malvicini, Mariana, Tirado-González, Irene, García, Mariana G, Alaniz, Laura, Mazzolini, Guillermo

“…Cirrhosis is characterized by an excessive accumulation of extracellular matrix components including hyaluronic acid (HA) and is widely considered a…”
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Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients by Onorato, Agostina M, Lameroli Mauriz, Lucía, Bayo, Juan, Fiore, Esteban, Cantero, María José, Bueloni, Barbara, García, Mariana, Lagües, Cecilia, Martínez-Duartez, Pedro, Menaldi, Gabriel, Paleari, Nicolas, Atorrasagasti, Catalina, Mazzolini, Guillermo D

“…The severity of non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to steatohepatitis, and it is not yet clearly understood which patients…”
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Mesenchymal stromal cells engineered to produce IGF-I by recombinant adenovirus ameliorate liver fibrosis in mice by Fiore, Esteban J, Bayo, Juan M, Garcia, Mariana G, Malvicini, Mariana, Lloyd, Rodrigo, Piccioni, Flavia, Rizzo, Manglio, Peixoto, Estanislao, Sola, M Beatriz, Atorrasagasti, Catalina, Alaniz, Laura, Camilletti, María A, Enguita, Mónica, Prieto, Jesús, Aquino, Jorge B, Mazzolini, Guillermo

“…Liver cirrhosis involves chronic wound healing and fibrotic processes. Mesenchymal stromal cells (MSCs) are multipotent adult progenitor cells that are used as…”
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Acceleration of TAA-Induced Liver Fibrosis by Stress Exposure Is Associated with Upregulation of Nerve Growth Factor and Glycopattern Deviations by Atorrasagasti, Catalina, Piccioni, Flavia, Borowski, Sophia, Tirado-González, Irene, Freitag, Nancy, Cantero, María José, Bayo, Juan, Mazzolini, Guillermo, Alaniz, Laura D., Blois, Sandra M., Garcia, Mariana G.

“…Liver fibrosis results from many chronic injuries and may often progress to cirrhosis and hepatocellular carcinoma (HCC). In fact, up to 90% of HCC arise in a…”
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Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice by Atorrasagasti, Catalina, Peixoto, Estanislao, Aquino, Jorge B, Kippes, Néstor, Malvicini, Mariana, Alaniz, Laura, Garcia, Mariana, Piccioni, Flavia, Fiore, Esteban J, Bayo, Juan, Bataller, Ramón, Guruceaga, Elizabeth, Corrales, Fernando, Podhajcer, Osvaldo, Mazzolini, Guillermo

“…Secreted Protein, Acidic and Rich in Cysteine (SPARC) is a matricellular protein involved in many biological processes and found over-expressed in cirrhotic…”
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Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells by Fiore, Esteban, Malvicini, Mariana, Bayo, Juan, Peixoto, Estanislao, Atorrasagasti, Catalina, Sierra, Romina, Rodríguez, Marcelo, Gómez Bustillo, Sofia, García, Mariana G, Aquino, Jorge B, Mazzolini, Guillermo

“…Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have a pivotal role in liver fibrosis, being able to act…”
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Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells by Atorrasagasti, Catalina, Malvicini, Mariana, Aquino, Jorge B., Alaniz, Laura, Garcia, Mariana, Bolontrade, Marcela, Rizzo, Manglio, Podhajcer, Osvaldo L., Mazzolini, Guillermo

“…Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer‐related death worldwide. Current treatments are extremely…”
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A Novel Synergistic Combination of Cyclophosphamide and Gene Transfer of Interleukin-12 Eradicates Colorectal Carcinoma in Mice by MALVICINI, Mariana, RIZZO, Miguel, MAZZOLINI, Guillermo, ALANIZ, Laura, PINERO, Federico, GARCIA, Mariana, ATORRASAGASTI, Catalina, AQUINO, Jorge B, ROZADOS, Viviana, GRACIELA SCHAROVSKY, O, MATAR, Pablo

“…Purpose: Interleukin-12 (IL-12) is an immunostimulatory cytokine with potent antitumor effects in several animal models. However, serious toxicity has been…”
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Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats by Camino, Alejandra M., Atorrasagasti, Catalina, Maccio, Daniela, Prada, Federico, Salvatierra, Edgardo, Rizzo, Miguel, Alaniz, Laura, Aquino, Jorge B., Podhajcer, Osvaldo. L., Silva, Marcelo, Mazzolini, Guillermo

“…Background The interaction between fibrogenic cells and extracellular matrix plays a role in liver fibrosis, yet the mechanisms are largely unknown. Secreted…”
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Immunotherapy and immunoescape in colorectal cancer by Mazzolini, Guillermo, Murillo, Oihana, Atorrasagasti, Catalina, Dubrot, Juan, Tirapu, Iñigo, Rizzo, Miguel, Arina, Ainhoa, Alfaro, Carlos, Azpilicueta, Arantza, Berasain, Carmen, Perez-Gracia, José L, Gonzalez, Alvaro, Melero, Ignacio

“…Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal…”
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Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice by Malvicini, Mariana, Alaniz, Laura, Bayo, Juan, Garcia, Mariana, Piccioni, Flavia, Fiore, Esteban, Atorrasagasti, Catalina, Aquino, Jorge B., Matar, Pablo, Mazzolini, Guillermo

“…The use of conventional cytotoxic agents at metronomic schedules, alone or in combination with targeted agents or immunotherapy, is being explored as a…”
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