Search Results - "Atmaramani, Rahul"
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Adult mouse sensory neurons on microelectrode arrays exhibit increased spontaneous and stimulus-evoked activity in the presence of interleukin-6
Published in Journal of neurophysiology (01-09-2018)“…Following inflammation or injury, sensory neurons located in the dorsal root ganglia (DRG) may exhibit increased spontaneous and/or stimulus-evoked activity,…”
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Journal Article -
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Emerging neurotechnology for antinoceptive mechanisms and therapeutics discovery
Published in Biosensors & bioelectronics (01-02-2019)“…The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative…”
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3
Spontaneous and Evoked Activity from Murine Ventral Horn Cultures on Microelectrode Arrays
Published in Frontiers in cellular neuroscience (29-09-2017)“…Motor neurons are the site of action for several neurological disorders and paralytic toxins, with cell bodies located in the ventral horn (VH) of the spinal…”
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Investigating the Function of Adult DRG Neuron Axons Using an In Vitro Microfluidic Culture System
Published in Micromachines (Basel) (27-10-2021)“…A critical role of the peripheral axons of nociceptors of the dorsal root ganglion (DRG) is the conduction of all-or-nothing action potentials from peripheral…”
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Conserved Expression of Nav1.7 and Nav1.8 Contribute to the Spontaneous and Thermally Evoked Excitability in IL-6 and NGF-Sensitized Adult Dorsal Root Ganglion Neurons In Vitro
Published in Bioengineering (Basel) (16-05-2020)“…Sensory neurons respond to noxious stimuli by relaying information from the periphery to the central nervous system via action potentials driven by…”
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Liquid Crystal Elastomer-Based Microelectrode Array for In Vitro Neuronal Recordings
Published in Micromachines (Basel) (20-08-2018)“…Polymer-based biomedical electronics provide a tunable platform to interact with nervous tissue both in vitro and in vivo. Ultimately, the ability to control…”
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The Effect of Microfluidic Geometry on Myoblast Migration
Published in Micromachines (Basel) (21-02-2019)“…In vitro systems comprised of wells interconnected by microchannels have emerged as a platform for the study of cell migration or multicellular models. In the…”
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Photo-Magnetic Irradiation-Mediated Multimodal Therapy of Neuroblastoma Cells Using a Cluster of Multifunctional Nanostructures
Published in Nanomaterials (Basel, Switzerland) (29-09-2018)“…The use of high intensity chemo-radiotherapies has demonstrated only modest improvement in the treatment of high-risk neuroblastomas. Moreover, undesirable…”
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Adaptation of robust Z’ factor for assay quality assessment in microelectrode array based screening using adult dorsal root ganglion neurons
Published in Journal of neuroscience methods (01-06-2020)“…•A robust version of Z’-factor was developed for assay quality interpretation for primary DRG neuron-based assay for screening analgesics.•Log-transformed…”
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Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation
Published in Acta biomaterialia (01-01-2020)“…We have characterized the in vitro and in vivo extracellular neural recording and stimulation properties of ruthenium oxide (RuOx) based microelectrodes…”
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Development of an In Vitro Phenotypic Assay for Screening Chronic Pain Therapeutics
Published 01-01-2020“…Dorsal root ganglia (DRG) are a collection of first order sensory neurons involved in the perception of innocuous as well as noxious stimuli, and the…”
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Dissertation -
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Enhanced proliferation of PC12 neural cells on untreated, nanotextured glass coverslips
Published in Nanotechnology (14-10-2016)“…Traumatic injury to the central nervous system is a significant health problem. There is no effective treatment available partly because of the complexity of…”
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Journal Article -
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A peptide encoded within a 5′ untranslated region promotes pain sensitization in mice
Published in Pain (Amsterdam) (01-06-2021)“…Translational regulation permeates neuronal function. Nociceptors are sensory neurons responsible for the detection of harmful stimuli. Changes in their…”
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A peptide encoded within a 5′ untranslated region promotes pain sensitization in mice
Published in Pain (Amsterdam) (11-01-2021)Get full text
Journal Article