Search Results - "Atkinson, Simon J."

Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection by Kolb, Alexander L, Corridon, Peter R, Zhang, Shijun, Xu, Weimin, Witzmann, Frank A, Collett, Jason A, Rhodes, George J, Winfree, Seth, Bready, Devin, Pfeffenberger, Zechariah J, Pomerantz, Jeremy M, Hato, Takashi, Nagami, Glenn T, Molitoris, Bruce A, Basile, David P, Atkinson, Simon J, Bacallao, Robert L

“…Ischemic preconditioning confers organ-wide protection against subsequent ischemic stress. A substantial body of evidence underscores the importance of…”
Get full text

A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vectors by Corridon, Peter R, Rhodes, George J, Leonard, Ellen C, Basile, David P, Gattone, 2nd, Vincent H, Bacallao, Robert L, Atkinson, Simon J

“…Gene therapy has been proposed as a novel alternative to treat kidney disease. This goal has been hindered by the inability to reliably deliver transgenes to…”
Get more information

Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases by Gu, Yi, Filippi, Marie-Dominique, Cancelas, Jose A., Siefring, Jamie E., Williams, Emily P., Jasti, Aparna C., Harris, Chad E., Lee, Andrew W., Prabhakar, Rethinasamy, Atkinson, Simon J., Kwiatkowski, David J., Williams, David A.

“…The Rho guanosine triphosphatases (GTPases) Rad and Rac1 are critical signaling regulators in mammalian cells. The deletion of both Rac1 and Rac2 murine…”
Get full text

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics by Allen, Jayme D., Jaffer, Zahara M., Park, Su-Jung, Burgin, Sarah, Hofmann, Clemens, Sells, Mary Ann, Chen, Shi, Derr-Yellin, Ethel, Michels, Elizabeth G., McDaniel, Andrew, Bessler, Waylan K., Ingram, David A., Atkinson, Simon J., Travers, Jeffrey B., Chernoff, Jonathan, Clapp, D. Wade

“…Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators…”
Get full text

Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization by Ransom, Richard F., Lam, Nancy G., Hallett, Mark A., Atkinson, Simon J., Smoyer, William E.

“…Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization. Nephrotic syndrome is a common kidney disease in…”
Get full text

Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation by Dey, Asim B., Khedr, Sherif, Bean, James, Porras, Leah L., Meredith, Tamika D., Willard, Francis S., Hass, Joseph V., Zhou, Xin, Terashvili, Maia, Jesudason, Cynthia D., Ruley, Kevin M., Wiley, Michael R., Kowala, Mark, Atkinson, Simon J., Staruschenko, Alexander, Rekhter, Mark D.

“…Regulation of the peripheral vascular resistance via modulating the vessel diameter has been considered as a main determinant of the arterial blood pressure…”
Get full text

Functional studies of the kidney of living animals using multicolor two-photon microscopy by Dunn, Kenneth W, Sandoval, Ruben M, Kelly, Katherine J, Dagher, Pierre C, Tanner, George A, Atkinson, Simon J, Bacallao, Robert L, Molitoris, Bruce A

“…Optical microscopy, when applied to living animals, provides a powerful means of studying cell biology in the most physiologically relevant setting. The…”
Get more information

Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation by Campos, Silvia B, Ashworth, Sharon L, Wean, Sarah, Hosford, Melanie, Sandoval, Ruben M, Hallett, Mark A, Atkinson, Simon J, Molitoris, Bruce A

“…Acute ischemic kidney injury results in marked increases in local and systemic cytokine levels. IL-1alpha, IL-6, and TNF-alpha orchestrate various inflammatory…”
Get more information

RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC) by Chen, Neal X, Chen, Xianming, O'Neill, Kalisha D, Atkinson, Simon J, Moe, Sharon M

“…RhoA/Rho kinases (ROCK) play a critical role in vascular smooth muscle cell (VSMC) actin cytoskeleton organization, differentiation, and function and are…”
Get more information

Kidney surveillance in the spotlight: contrast-induced acute kidney injury illuminated by Atkinson, Simon J

“…Acute kidney injury comprises a heterogeneous group of conditions characterized by a sudden decrease in renal function over hours to days. Contrast-induced…”
Get full text

Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles by Yamauchi, Akira, Kim, Chaekyun, Li, Shijun, Marchal, Christophe C, Towe, Jason, Atkinson, Simon J, Dinauer, Mary C

“…The Rho family GTPase Rac is a crucial participant in numerous cellular functions and acts as a molecular switch for signal transduction. Mice deficient in…”
Get full text

Mechanism of Actin Polymerization in Cellular ATP Depletion by Atkinson, Simon J., Hosford, Melanie A., Molitoris, Bruce A.

“…Cellular ATP depletion in diverse cell types results in the net conversion of monomeric G-actin to polymeric F-actin and is an important aspect of cellular…”
Get full text

A wandering path toward prevention for acute kidney injury by Atkinson, Simon J

“…Acute kidney injury (AKI) is a common cause of hospital-related mortality; therefore, strategies to either prevent or treat this complication are of great…”
Get full text

aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion by Gopalakrishnan, Shobha, Hallett, Mark A, Atkinson, Simon J, Marrs, James A

“…Renal ischemia and in vitro ATP depletion result in disruption of the epithelial tight junction barrier, which is accompanied by breakdown of plasma membrane…”
Get more information

Sulfotransferase 1C2 Increases Mitochondrial Respiration by Converting Mitochondrial Membrane Cholesterol to Cholesterol Sulfate by Kolb, Alexander J., Corridon, Peter, Ullah, Mahbub, Pfaffenberger, Zechariah J., Xu, Wei Min, Winfree, Seth, Sandoval, Ruben H., Hato, Takeshi, Witzmann, Frank A., Mohallem, Rodrigo, Franco, Jackeline, Aryal, Uma K., Atkinson, Simon J., Basile, David P., Bacallao, Robert L.

“…Hypothesis: In this communication, we test the hypothesis that sulfotransferase 1C2 (SULT1C2, UniProt accession no. Q9WUW8) can modulate mitochondrial…”
Get full text

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury by MOLITORIS, Bruce A, DAGHER, Pierre C, KALINSKI, Hagar, SKALITER, Rami, ERLICH, Shai, FEINSTEIN, Elena, SANDOVAL, Ruben M, CAMPOS, Silvia B, ASHUSH, Hagit, FRIDMAN, Eduard, BRAFMAN, Anat, FAERMAN, Alexander, ATKINSON, Simon J, THOMPSON, James D

“…Proximal tubule cells (PTCs), which are the primary site of kidney injury associated with ischemia or nephrotoxicity, are the site of oligonucleotide…”
Get full text

Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys by Collett, Jason A, Corridon, Peter R, Mehrotra, Purvi, Kolb, Alexander L, Rhodes, George J, Miller, Caroline A, Molitoris, Bruce A, Pennington, Janice G, Sandoval, Ruben M, Atkinson, Simon J, Campos-Bilderback, Silvia B, Basile, David P, Bacallao, Robert L

“…Highly aerobic organs like the kidney are innately susceptible to ischemia-reperfusion (I/R) injury, which can originate from sources including myocardial…”
Get full text

Rho GTPases show differential sensitivity to nucleotide triphosphate depletion in a model of ischemic cell injury by Hallett, Mark A, Dagher, Pierre C, Atkinson, Simon J

“…Rho GTPases are critical for actin cytoskeletal regulation, and alterations in their activity may contribute to altered cytoskeletal organization that…”
Get more information

Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis by Li, Deqiang, Hallett, Mark A, Zhu, Wuqiang, Rubart, Michael, Liu, Ying, Yang, Zhenyun, Chen, Hanying, Haneline, Laura S, Chan, Rebecca J, Schwartz, Robert J, Field, Loren J, Atkinson, Simon J, Shou, Weinian

“…Dishevelled-associated activator of morphogenesis 1 (Daam1), a member of the formin protein family, plays an important role in regulating the actin…”
Get full text

The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization by Tao, Wen, Filippi, Marie-Dominique, Bailey, Jeffrey R., Atkinson, Simon J., Connors, Bret, Evan, Andrew, Williams, David A.

“…Rac GTPases regulate a wide variety of cellular processes including actin cytoskeleton organization, gene expression, cell-cycle progression, and apoptosis…”
Get full text