Search Results - "Atkinson, Karen M"

Precision and accuracy of hyperglycemic clamps in a multicenter study by Mather, Kieren J, Tjaden, Ashley H, Hoehn, Adam, Nadeau, Kristen J, Buchanan, Thomas A, Kahn, Steven E, Arslanian, Silva A, Caprio, Sonia, Atkinson, Karen M, Cree-Green, Melanie, Utzschneider, Kristina M, Edelstein, Sharon L

“…Application of glucose clamp methodologies in multicenter studies brings challenges for standardization. The Restoring Insulin Secretion (RISE) Consortium…”
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1794-P: Successful Standardization of a Hyperglycemic Clamp Method across Multiple Clinical Centers in the Restoring Insulin Secretion (RISE) Study by MATHER, KIEREN J., TJADEN, ASHLEY H., ARSLANIAN, SILVA A., UTZSCHNEIDER, KRISTINA, CAPRIO, SONIA, ATKINSON, KAREN M., CREE-GREEN, MELANIE, NADEAU, KRISTEN J., BUCHANAN, THOMAS A., KAHN, STEVEN E.

“…In RISE, repeated measurements of β-cell function and insulin sensitivity were performed using a standardized hyperglycemic glucose clamp method. After in…”
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1679-P: Islet Autoimmunity in Adults with Impaired Glucose Tolerance (IGT) and Newly Diagnosed, Treatment-Naïve Type 2 Diabetes (NDX T2D) in the Restoring Insulin Secretion (RISE) Study by BROOKS-WORRELL, BARBARA, TJADEN, ASHLEY H., EDELSTEIN, SHARON, PALOMINO, BRENDA M., UTZSCHNEIDER, KRISTINA, ARSLANIAN, SILVA A., MATHER, KIEREN J., BUCHANAN, THOMAS A., NADEAU, KRISTEN J., ATKINSON, KAREN M., BARENGOLTS, ELENA, KAHN, STEVEN E., PALMER, JERRY P.

“…In obesity, immune cells establish a systemic inflammatory state associated with development of insulin resistance and T2D. Previous studies have shown that…”
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Within-Trial Cost-Effectiveness of a Structured Lifestyle Intervention in Adults With Overweight/Obesity and Type 2 Diabetes: Results From the Action for Health in Diabetes (Look AHEAD) Study by Zhang, Ping, Atkinson, Karen M, Bray, George A, Chen, Haiying, Clark, Jeanne M, Coday, Mace, Dutton, Gareth R, Egan, Caitlin, Espeland, Mark A, Evans, Mary, Foreyt, John P, Greenway, Frank L, Gregg, Edward W, Hazuda, Helen P, Hill, James O, Horton, Edward S, Hubbard, Van S, Huckfeldt, Peter J, Jackson, Sharon D, Jakicic, John M, Jeffery, Robert W, Johnson, Karen C, Kahn, Steven E, Killean, Tina, Knowler, William C, Korytkowski, Mary, Lewis, Cora E, Maruthur, Nisa M, Michaels, Sara, Montez, Maria G, Nathan, David M, Patricio, Jennifer, Peters, Anne, Pi-Sunyer, Xavier, Pownall, Henry, Redmon, Bruce, Rushing, Julia T, Steinburg, Helmut, Wadden, Thomas A, Wing, Rena R, Wyatt, Holly, Yanovski, Susan Z

“…To assess the cost-effectiveness (CE) of an intensive lifestyle intervention (ILI) compared with standard diabetes support and education (DSE) in adults with…”
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Association of Habitual Daily Physical Activity With Glucose Tolerance and β-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study by Temple, Karla A, Tjaden, Ashley H, Atkinson, Karen M, Barengolts, Elena, Hannon, Tamara S, Mather, Kieren J, Utzschneider, Kristina M, Edelstein, Sharon L, Ehrmann, David A, Mokhlesi, Babak

“…We examined the relationship between habitual daily physical activity and measures of glucose tolerance, insulin sensitivity, and β-cell responses in adults…”
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Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2 Diabetes in the Restoring Insulin SEcretion (RISE) Study by Brooks-Worrell, Barbara M, Tjaden, Ashley H, Edelstein, Sharon L, Palomino, Brenda, Utzschneider, Kristina M, Arslanian, Silva, Mather, Kieren J, Buchanan, Thomas A, Nadeau, Kristen J, Atkinson, Karen, Barengolts, Elena, Kahn, Steven E, Palmer, Jerry P

“…The presence of islet autoantibodies and islet reactive T cells (T+) in adults with established type 2 diabetes (T2D) have been shown to identify those…”
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Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp by Ehrmann, David A., Temple, Karla A., Rue, Abby, Barengolts, Elena, Mokhlesi, Babak, Van Cauter, Eve, Sam, Susan, Miller, M. Annette, Kahn, Steven E., Atkinson, Karen M., Palmer, Jerry P., Utzschneider, Kristina M., Gebremedhin, Tsige, Kernan-Schloss, Abigail, Kozedub, Alexandra, Montgomery, Brenda K., Morse, Emily J., Mather, Kieren J., Garrett, Tammy, Hannon, Tamara S., Lteif, Amale, Patel, Aniket, Chisholm, Robin, Moore, Karen, Pirics, Vivian, Pratt, Linda, Nadeau, Kristen J., Gross, Susan, Zeitler, Philip S., Williams, Jayne, Cree-Green, Melanie, Garcia Reyes, Yesenia, Vissat, Krista, Arslanian, Silva A., Brown, Kathleen, Guerra, Nancy, Porter, Kristin, Caprio, Sonia, Savoye, Mary, Pierpont, Bridget, Buchanan, Thomas A., Xiang, Anny H., Trigo, Enrique, Beale, Elizabeth, Hendee, Fadi N., Katkhouda, Namir, Nayak, Krishan, Martinez, Mayra, Montgomery, Cortney, Wang, Xinhui, Edelstein, Sharon L., Lachin, John M., Hogan, Ashley N., Marcovina, Santica, Harting, Jessica, Albers, John, Hill, Dave, Savage, Peter J., Leschek, Ellen W.

“…To compare insulin sensitivity (M/I) and β-cell responses in youth versus adults with impaired glucose tolerance (IGT) or drug-naïve, recently diagnosed type 2…”
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Impact of Insulin and Metformin Versus Metformin Alone on β-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes by Nadeau, Kristen J., Hannon, Tamara S., Edelstein, Sharon L., Arslanian, Silva A., Caprio, Sonia, Leschek, Ellen W., Zeitler, Philip S., Buchanan, Thomas A., Ehrmann, David A., Mather, Kieren J., Kahn, Steven E., Gross, Susan, Williams, Jayne, Cree-Green, Melanie, Reyes, Yesenia Garcia, Vissat, Krista, Brown, Kathleen, Guerra, Nancy, Porter, Kristin, Savoye, Mary, Pierpont, Bridget, Garrett, Tammy, Lteif, Amale, Patel, Aniket, Chisholm, Robin, Moore, Karen, Pirics, Vivian, Pratt, Linda, Temple, Karla A., Rue, Abby, Barengolts, Elena, Mokhlesi, Babak, Van Cauter, Eve, Sam, Susan, Miller, M. Annette, Atkinson, Karen M., Palmer, Jerry P., Utzschneider, Kristina M., Gebremedhin, Tsige, Kernan-Schloss, Abigail, Kozedub, Alexandra, Montgomery, Brenda K., Morse, Emily J., Xiang, Anny H., Trigo, Enrique, Beale, Elizabeth, Hendee, Fadi N., Katkhouda, Namir, Nayak, Krishan, Martinez, Mayra, Montgomery, Cortney, Wang, Xinhui, Lachin, John M., Hogan, Ashley N., Marcovina, Santica, Harting, Jessica, Albers, John, Hill, Dave, Savage, Peter J.

“…Pediatric type 2 diabetes prevalence is increasing, with β-cell dysfunction key in its pathogenesis. The RISE Pediatric Medication Study compared two…”
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Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test by Ehrmann, David A., Temple, Karla A., Rue, Abby, Barengolts, Elena, Mokhlesi, Babak, Van Cauter, Eve, Sam, Susan, Miller, M. Annette, Kahn, Steven E., Atkinson, Karen M., Palmer, Jerry P., Utzschneider, Kristina M., Gebremedhin, Tsige, Kernan-Schloss, Abigail, Kozedub, Alexandra, Montgomery, Brenda K., Morse, Emily J., Mather, Kieren J., Garrett, Tammy, Hannon, Tamara S., Lteif, Amale, Patel, Aniket, Chisholm, Robin, Moore, Karen, Pirics, Vivian, Pratt, Linda, Nadeau, Kristen J., Gross, Susan, Zeitler, Philip S., Williams, Jayne, Green, Melanie-Cree, Garcia Reyes, Yesenia, Vissat, Krista, Arslanian, Silva A., Brown, Kathleen, Guerra, Nancy, Porter, Kristin, Caprio, Sonia, Savoye, Mary, Pierpont, Bridget, Buchanan, Thomas A., Xiang, Anny H., Trigo, Enrique, Beale, Elizabeth, Hendee, Fadi N., Katkhouda, Namir, Nayak, Krishan, Martinez, Mayra, Montgomery, Cortney, Wang, Xinhui, Edelstein, Sharon L., Lachin, John M., Hogan, Ashley N., Marcovina, Santica, Harting, Jessica, Albers, John, Hill, Dave, Savage, Peter J., Leschek, Ellen W.

“…To compare oral glucose tolerance test (OGTT) glucose, C-peptide, and insulin responses and insulin sensitivity in youth and adults with impaired glucose…”
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Lack of Durable Improvements in β-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes by Ehrmann, David A., Temple, Karla A., Rue, Abby, Barengolts, Elena, Mokhlesi, Babak, Van Cauter, Eve, Sam, Susan, Miller, M. Annette, Kahn, Steven E., Atkinson, Karen M., Palmer, Jerry P., Utzschneider, Kristina M., Gebremedhin, Tsige, Kernan-Schloss, Abigail, Kozedub, Alexandra, Montgomery, Brenda K., Morse, Emily J., Mather, Kieren J., Garrett, Tammy, Hannon, Tamara S., Lteif, Amale, Patel, Aniket, Chisholm, Robin, Moore, Karen, Pirics, Vivian, Pratt, Linda, Nadeau, Kristen J., Gross, Susan, Zeitler, Philip S., Williams, Jayne, Cree-Green, Melanie, Garcia Reyes, Yesenia, Vissat, Krista, Arslanian, Silva A., Brown, Kathleen, Guerra, Nancy, Porter, Kristin, Caprio, Sonia, Savoye, Mary, Pierpont, Bridget, Buchanan, Thomas A., Xiang, Anny H., Trigo, Enrique, Beale, Elizabeth, Chow, Ting, Hendee, Fadi N., Katkhouda, Namir, Nayak, Krishan, Martinez, Mayra, Montgomery, Cortney, Wang, Xinhui, Wu, Jun, Edelstein, Sharon L., Lachin, John M., Tjaden, Ashley Hogan, Marcovina, Santica, Harting, Jessica, Albers, John, Hill, Dave, Savage, Peter J., Leschek, Ellen W.

“…The Restoring Insulin Secretion (RISE) Adult Medication Study compared pharmacological approaches targeted to improve β-cell function in individuals with…”
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Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes by Mokhlesi, Babak, Temple, Karla A, Tjaden, Ashley H, Edelstein, Sharon L, Utzschneider, Kristina M, Nadeau, Kristen J, Hannon, Tamara S, Sam, Susan, Barengolts, Elena, Manchanda, Shalini, Ehrmann, David A, Van Cauter, Eve

“…Sleep disturbances and circadian misalignment (social jet lag, late chronotype, or shift work) have been associated with worse glycemic control in type 2…”
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Baseline Predictors of Glycemic Worsening in Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study by Sam, Susan, Edelstein, Sharon L, Arslanian, Silva A, Barengolts, Elena, Buchanan, Thomas A, Caprio, Sonia, Ehrmann, David A, Hannon, Tamara S, Tjaden, Ashley Hogan, Kahn, Steven E, Mather, Kieren J, Tripputi, Mark, Utzschneider, Kristina M, Xiang, Anny H, Nadeau, Kristen J

“…To identify predictors of glycemic worsening among youth and adults with impaired glucose tolerance (IGT) or recently diagnosed type 2 diabetes in the…”
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OGTT Glucose Response Curves, Insulin Sensitivity, and β-Cell Function in RISE: Comparison Between Youth and Adults at Randomization and in Response to Interventions to Preserve β-Cell Function by Arslanian, Silva A, El Ghormli, Laure, Kim, Joon Young, Tjaden, Ashley H, Barengolts, Elena, Caprio, Sonia, Hannon, Tamara S, Mather, Kieren J, Nadeau, Kristen J, Utzschneider, Kristina M, Kahn, Steven E

“…We examined the glucose response curves (biphasic [BPh], monophasic [MPh], incessant increase [IIn]) during an oral glucose tolerance test (OGTT) and their…”
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1832-P: Impact of Habitual Daily Activity on Glucose Tolerance (GT) and ß-Cell Function in Adults with Impaired GT (IGT) or Type 2 Diabetes (T2D) by TEMPLE, KARLA A., TJADEN, ASHLEY H., ATKINSON, KAREN M., BARENGOLTS, ELENA, HANNON, TAMARA S., MATHER, KIEREN J., UTZSCHNEIDER, KRISTINA, EHRMANN, DAVID A., MOKHLESI, BABAK

“…We examined the relationship between habitual daily activity and measures of GT, insulin sensitivity and β-cell responses in 230 adults (mean age 55 y; BMI 35…”
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Obstructive Sleep Apnea, Glucose Tolerance, and β-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study by Mokhlesi, Babak, Tjaden, Ashley H, Temple, Karla A, Edelstein, Sharon L, Sam, Susan, Nadeau, Kristen J, Hannon, Tamara S, Manchanda, Shalini, Mather, Kieren J, Kahn, Steven E, Ehrmann, David A, Van Cauter, Eve

“…Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts…”
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Hyperglucagonemia Does Not Explain the β-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study by Kahn, Steven E, Mather, Kieren J, Arslanian, Silva A, Barengolts, Elena, Buchanan, Thomas A, Caprio, Sonia, Ehrmann, David A, Hannon, Tamara S, Marcovina, Santica, Nadeau, Kristen J, Utzschneider, Kristina M, Xiang, Anny H, Edelstein, Sharon L

“…To determine whether β-cell hyperresponsiveness and insulin resistance in youth versus adults in the Restoring Insulin Secretion (RISE) Study are related to…”
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Impact of Gastric Banding Versus Metformin on β-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes by Xiang, Anny H, Trigo, Enrique, Martinez, Mayra, Katkhouda, Namir, Beale, Elizabeth, Wang, Xinhui, Wu, Jun, Chow, Ting, Montgomery, Cortney, Nayak, Krishna S, Hendee, Fadi, Buchanan, Thomas A

“…Type 2 diabetes (T2D) results from progressive loss of β-cell function. The BetaFat study compared gastric banding and metformin for their impact on β-cell…”
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Effect of Medical and Surgical Interventions on α-Cell Function in Dysglycemic Youth and Adults in the RISE Study by Kahn, Steven E, Edelstein, Sharon L, Arslanian, Silva A, Barengolts, Elena, Caprio, Sonia, Ehrmann, David A, Hannon, Tamara S, Marcovina, Santica, Mather, Kieren J, Nadeau, Kristen J, Utzschneider, Kristina M, Xiang, Anny H, Buchanan, Thomas A

“…To compare effects of medications and laparoscopic gastric band surgery (LB) on α-cell function in dysglycemic youth and adults in the Restoring Insulin…”
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Withdrawal of medications leads to worsening of OGTT parameters in youth with impaired glucose tolerance or recently‐diagnosed type 2 diabetes by Hannon, Tamara S., Edelstein, Sharon L., Arslanian, Silva A., Caprio, Sonia, Zeitler, Philip S., Buchanan, Thomas A., Ehrmann, David A., Mather, Kieren J., Tripputi, Mark, Kahn, Steven E., Nadeau, Kristen J.

“…Background The RISE Pediatric Medication Study compared strategies for preserving β‐cell function, including a 9‐month follow‐up after treatment withdrawal to…”
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Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults by Ehrmann, David A., Temple, Karla A., Rue, Abby, Barengolts, Elena, Mokhlesi, Babak, Van Cauter, Eve, Sam, Susan, Miller, M. Annette, Kahn, Steven E., Atkinson, Karen M., Palmer, Jerry P., Utzschneider, Kristina M., Gebremedhin, Tsige, Kernan-Schloss, Abigail, Kozedub, Alexandra, Montgomery, Brenda K., Morse, Emily J., Mather, Kieren J., Garrett, Tammy, Hannon, Tamara S., Lteif, Amale, Patel, Aniket, Chisholm, Robin, Moore, Karen, Pirics, Vivian, Pratt, Linda, Nadeau, Kristen J., Gross, Susan, Zeitler, Philip S., Williams, Jayne, Green, Melanie Cree, Garcia Reyes, Yesenia, Vissat, Krista, Arslanian, Silva A., Brown, Kathleen, Guerra, Nancy, Porter, Kristin, Caprio, Sonia, Savoye, Mary, Pierpont, Bridget, Buchanan, Thomas A., Xiang, Anny H., Trigo, Enrique, Beale, Elizabeth, Hendee, Fadi N., Katkhouda, Namir, Nayak, Krishan, Martinez, Mayra, Montgomery, Cortney, Wang, Xinhui, Edelstein, Sharon L., Lachin, John M., Hogan, Ashley N., Marcovina, Santica, Harting, Jessica, Albers, John, Hill, Dave, Savage, Peter J., Leschek, Ellen W.

“…Background Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin…”
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