Search Results - "Atkinson, Joshua"
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Inter-kingdom electromechanical communication
Published in Nature chemical biology (01-10-2024)“…The field of engineered living materials (ELMs) involves incorporating cells into materials to enable new functionalities. Now, ELMs have been developed that…”
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Real-time bioelectronic sensing of environmental contaminants
Published in Nature (London) (17-11-2022)“…Real-time chemical sensing is crucial for applications in environmental and health monitoring 1 . Biosensors can detect a variety of molecules through genetic…”
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Dissipative Assembly of Macrocycles Comprising Multiple Transient Bonds
Published in Angewandte Chemie (International ed.) (10-08-2020)“…Dissipative assembly has great potential for the creation of new adaptive chemical systems. However, while molecular assembly at equilibrium is routinely used…”
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The Biochemical Impact of Extracting an Embedded Adenylate Kinase Domain Using Circular Permutation
Published in Biochemistry (Easton) (05-03-2024)“…Adenylate kinases (AKs) have evolved AMP-binding and lid domains that are encoded as continuous polypeptides embedded at different locations within the…”
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Cellular Assays for Ferredoxins: A Strategy for Understanding Electron Flow through Protein Carriers That Link Metabolic Pathways
Published in Biochemistry (Easton) (27-12-2016)“…The ferredoxin (Fd) protein family is a structurally diverse group of iron–sulfur proteins that function as electron carriers, linking biochemical pathways…”
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Solution‐Deposited and Patternable Conductive Polymer Thin‐Film Electrodes for Microbial Bioelectronics
Published in Advanced materials (Weinheim) (01-04-2022)“…Microbial bioelectronic devices integrate naturally occurring or synthetically engineered electroactive microbes with microelectronics. These devices have a…”
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Circular permutation profiling by deep sequencing libraries created using transposon mutagenesis
Published in Nucleic acids research (27-07-2018)“…Abstract Deep mutational scanning has been used to create high-resolution DNA sequence maps that illustrate the functional consequences of large numbers of…”
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Determinants of Multiheme Cytochrome Extracellular Electron Transfer Uncovered by Systematic Peptide Insertion
Published in Biochemistry (Easton) (05-07-2022)“…The multiheme cytochrome MtrA enables microbial respiration by transferring electrons across the outer membrane to extracellular electron acceptors. While…”
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Protein tolerance to random circular permutation correlates with thermostability and local energetics of residue-residue contacts
Published in Protein engineering, design and selection (31-12-2019)“…Adenylate kinase (AK) orthologs with a range of thermostabilities were subjected to random circular permutation, and deep mutational scanning was used to…”
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Metalloprotein switches that display chemical-dependent electron transfer in cells
Published in Nature chemical biology (01-02-2019)“…Biological electron transfer is challenging to directly regulate using environmental conditions. To enable dynamic, protein-level control over energy flow in…”
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Combinatorial design of chemical‐dependent protein switches for controlling intracellular electron transfer
Published in AIChE journal (01-03-2020)“…One challenge with controlling electron flow in cells is the lack of biomolecules that directly couple environmental sensing to electron transfer efficiency…”
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Overcoming component limitations in synthetic biology through transposon-mediated protein engineering
Published in Methods in enzymology (01-01-2019)“…Protein fission and fusion can be used to create biomolecules with new structures and functions, including circularly permuted proteins that require…”
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The energetics and evolution of oxidoreductases in deep time
Published in Proteins, structure, function, and bioinformatics (01-01-2024)“…The core metabolic reactions of life drive electrons through a class of redox protein enzymes, the oxidoreductases. The energetics of electron flow is…”
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Museums as Places: Two review cases and a transdisciplinary perspective
Published in E-rea : Revue d'etudes anglophones (15-12-2021)“…In this essay, we theorize the differences and similarities between rhetorical and cultural geographic approaches to the study of one example of a memory…”
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Introduction to Engineering Biology: A Conceptual Framework for Teaching Synthetic Biology
Published in ACS synthetic biology (16-06-2023)“…As the impacts of engineering biology grow, it is important to introduce the field early and in an accessible way. However, teaching engineering biology poses…”
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Living electronics: A catalogue of engineered living electronic components
Published in Microbial biotechnology (01-03-2023)“…Biology leverages a range of electrical phenomena to extract and store energy, control molecular reactions and enable multicellular communication. Microbes, in…”
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Life simplified: recompiling a bacterial genome for synonymous codon compression
Published in Synthetic biology (Oxford University Press) (01-01-2019)Get full text
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Prochlorococcus phage ferredoxin: structural characterization and electron transfer to cyanobacterial sulfite reductases
Published in The Journal of biological chemistry (31-07-2020)“…Marine cyanobacteria are infected by phages whose genomes encode ferredoxin (Fd) electron carriers. These Fds are thought to redirect the energy harvested from…”
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A Split Methyl Halide Transferase AND Gate That Reports by Synthesizing an Indicator Gas
Published in ACS synthetic biology (20-11-2020)“…Monitoring microbial reactions in highly opaque or autofluorescent environments like soils, seawater, and wastewater remains challenging. To develop a simple…”
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A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors
Published in Cells (Basel, Switzerland) (06-10-2020)“…More than 1.5 million people suffer from Retinitis Pigmentosa, with many experiencing partial to complete vision loss. Regenerative therapies offer some hope,…”
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